Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia

The genetic components of insulin-resistance, diabetes and obesity have been largely studied. These conditions are determined by multiple polygenic and environmental factors. Certain candidate genes, that have common functional variants in the general population, may be important determinants of int...

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Autores principales:	Albala B,Cecilia, Jiménez R,Beatriz, Pérez B,Francisco, Liberman G,Claudio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Diabetes mellitus FABP2 protein, human Fatty acid-binding proteins Obesity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300017
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spelling	oai:scielo:S0034-988720060003000172006-05-02Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistenciaAlbala B,CeciliaJiménez R,BeatrizPérez B,FranciscoLiberman G,Claudio Diabetes mellitus FABP2 protein, human Fatty acid-binding proteins Obesity The genetic components of insulin-resistance, diabetes and obesity have been largely studied. These conditions are determined by multiple polygenic and environmental factors. Certain candidate genes, that have common functional variants in the general population, may be important determinants of inter-individual differences in the response to dietary changes. This review focuses in one of the major candidate genes, the gene encoding for the FABP2, an intracellular protein expressed only in the intestine, involved in the absorption and intracellular transport of dietary long chain fatty acids. Carriers of the Thr54 allele in FABP2 have a 2-fold greater affinity for long chain fatty acids than Ala54 carriers. The increased flux of dietary fatty acids (FA) into the circulation, among carriers of FABP2 Ala54Thr, supports a role of the polymorphism of this allele in the etiology of metabolic disorders. The frequencies of the polymorphism in different populations fluctuate between 18% and 40%. FABP2 Ala54Thr variant has been associated with an increased fasting insulin concentration, fasting fatty acid oxidation and reduced glucose uptake. This evidence, although not conclusive, sustains an association between FABP-2 genotype and metabolic abnormalitiesinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.3 20062006-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300017es10.4067/S0034-98872006000300017
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus FABP2 protein, human Fatty acid-binding proteins Obesity
spellingShingle	Diabetes mellitus FABP2 protein, human Fatty acid-binding proteins Obesity Albala B,Cecilia Jiménez R,Beatriz Pérez B,Francisco Liberman G,Claudio Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia
description	The genetic components of insulin-resistance, diabetes and obesity have been largely studied. These conditions are determined by multiple polygenic and environmental factors. Certain candidate genes, that have common functional variants in the general population, may be important determinants of inter-individual differences in the response to dietary changes. This review focuses in one of the major candidate genes, the gene encoding for the FABP2, an intracellular protein expressed only in the intestine, involved in the absorption and intracellular transport of dietary long chain fatty acids. Carriers of the Thr54 allele in FABP2 have a 2-fold greater affinity for long chain fatty acids than Ala54 carriers. The increased flux of dietary fatty acids (FA) into the circulation, among carriers of FABP2 Ala54Thr, supports a role of the polymorphism of this allele in the etiology of metabolic disorders. The frequencies of the polymorphism in different populations fluctuate between 18% and 40%. FABP2 Ala54Thr variant has been associated with an increased fasting insulin concentration, fasting fatty acid oxidation and reduced glucose uptake. This evidence, although not conclusive, sustains an association between FABP-2 genotype and metabolic abnormalities
author	Albala B,Cecilia Jiménez R,Beatriz Pérez B,Francisco Liberman G,Claudio
author_facet	Albala B,Cecilia Jiménez R,Beatriz Pérez B,Francisco Liberman G,Claudio
author_sort	Albala B,Cecilia
title	Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia
title_short	Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia
title_full	Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia
title_fullStr	Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia
title_full_unstemmed	Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia
title_sort	polimorfismo de la proteína ligante de ácidos grasos intestinal (fabp2), obesidad e insulina resistencia
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000300017
work_keys_str_mv	AT albalabcecilia polimorfismodelaproteinaligantedeacidosgrasosintestinalfabp2obesidadeinsulinaresistencia AT jimenezrbeatriz polimorfismodelaproteinaligantedeacidosgrasosintestinalfabp2obesidadeinsulinaresistencia AT perezbfrancisco polimorfismodelaproteinaligantedeacidosgrasosintestinalfabp2obesidadeinsulinaresistencia AT libermangclaudio polimorfismodelaproteinaligantedeacidosgrasosintestinalfabp2obesidadeinsulinaresistencia
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Polimorfismo de la proteína ligante de ácidos grasos intestinal (FABP2), obesidad e insulina resistencia

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