Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal

Background: One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Aim: To study pancreatic exocrine function in diabetics patients. Material and methods: Seventy two diabetic patients were included in the protocol, but two were withdrawn because an ab...

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Autores principales:	Mancilla A,Carla, Hurtado H,Carmen, Tobar A,Eduardo, Orellana N,Ivonne, Pineda B,Pedro, Castillo M,Iván, Ledezma R,Rodrigo, Berger F,Zoltán
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Diabetes mellitus Pancreatic elastase Pancreatitis, chronic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400001
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spelling	oai:scielo:S0034-988720060004000012014-01-23Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecalMancilla A,CarlaHurtado H,CarmenTobar A,EduardoOrellana N,IvonnePineda B,PedroCastillo M,IvánLedezma R,RodrigoBerger F,Zoltán Diabetes mellitus Pancreatic elastase Pancreatitis, chronic Background: One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Aim: To study pancreatic exocrine function in diabetics patients. Material and methods: Seventy two diabetic patients were included in the protocol, but two were withdrawn because an abdominal CAT scan showed a chronic calcified pancreatitis, previously undiagnosed. Fecal elastase was measured by ELISA and the presence of fat in feces was assessed using the steatocrit. Results: Mean age was 60±12 years and 67 (96%) patients had a type 2 diabetes. Fecal elastase was normal (elastase >200 µg/g) in 47 (67%) patients, mildly decreased (100-200 µg/g) in 10 (14%) and severely decreased in 13 (19%). There was a significant association between elastase levels and time of evolution of diabetes (p=0.049) and between lower elastase levels and the presence of a positive steatocrit (p=0.042). No significant association was found between elastase levels and other chronic complications of diabetes such as retinopathy, nephropathy, neuropathy, microangiopathy or with insulin requirement. Conclusions: One third of this group of diabetic patients had decreased levels of fecal elastase, that was associated with the time of evolution of diabetes. Patients with lower levels of elastase have significantly more steatorrhea. Among diabetics it is possible to find a group of patients with non diagnosed chronic pancreatitisinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.4 20062006-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400001es10.4067/S0034-98872006000400001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes mellitus Pancreatic elastase Pancreatitis, chronic
spellingShingle	Diabetes mellitus Pancreatic elastase Pancreatitis, chronic Mancilla A,Carla Hurtado H,Carmen Tobar A,Eduardo Orellana N,Ivonne Pineda B,Pedro Castillo M,Iván Ledezma R,Rodrigo Berger F,Zoltán Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal
description	Background: One of the complications of diabetes mellitus is the development of pancreatic exocrine insufficiency. Aim: To study pancreatic exocrine function in diabetics patients. Material and methods: Seventy two diabetic patients were included in the protocol, but two were withdrawn because an abdominal CAT scan showed a chronic calcified pancreatitis, previously undiagnosed. Fecal elastase was measured by ELISA and the presence of fat in feces was assessed using the steatocrit. Results: Mean age was 60±12 years and 67 (96%) patients had a type 2 diabetes. Fecal elastase was normal (elastase >200 µg/g) in 47 (67%) patients, mildly decreased (100-200 µg/g) in 10 (14%) and severely decreased in 13 (19%). There was a significant association between elastase levels and time of evolution of diabetes (p=0.049) and between lower elastase levels and the presence of a positive steatocrit (p=0.042). No significant association was found between elastase levels and other chronic complications of diabetes such as retinopathy, nephropathy, neuropathy, microangiopathy or with insulin requirement. Conclusions: One third of this group of diabetic patients had decreased levels of fecal elastase, that was associated with the time of evolution of diabetes. Patients with lower levels of elastase have significantly more steatorrhea. Among diabetics it is possible to find a group of patients with non diagnosed chronic pancreatitis
author	Mancilla A,Carla Hurtado H,Carmen Tobar A,Eduardo Orellana N,Ivonne Pineda B,Pedro Castillo M,Iván Ledezma R,Rodrigo Berger F,Zoltán
author_facet	Mancilla A,Carla Hurtado H,Carmen Tobar A,Eduardo Orellana N,Ivonne Pineda B,Pedro Castillo M,Iván Ledezma R,Rodrigo Berger F,Zoltán
author_sort	Mancilla A,Carla
title	Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal
title_short	Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal
title_full	Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal
title_fullStr	Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal
title_full_unstemmed	Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal
title_sort	función pancreática exocrina en diabetes mellitus: determinación de elastasa fecal
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400001
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Función pancreática exocrina en diabetes mellitus: Determinación de elastasa fecal

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