Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia

Background: Primary biliary cirrhosis (PBC) is a chronic cholestatic disease, which can progress to hepatic failure. Aim: To study the clinical presentation, pathological features, treatment and outcome of a group of patients with PBC. Material and methods: Retrospective review of medical records of...

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Autores principales:	Valera M,José Miguel, Smok S,Gladys, Poniachik T,Jaime, Oksenberg R,Danny, Silva P,Guillermo, Ferrario B,Mario, Buckel G,Erwin, Brahm B,Javier
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Liver Cirrhosis, Bilary Liver Cirrhosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400010
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spelling	oai:scielo:S0034-988720060004000102014-01-23Cirrosis biliar primaria: experiencia de trece años en dos centros de referenciaValera M,José MiguelSmok S,GladysPoniachik T,JaimeOksenberg R,DannySilva P,GuillermoFerrario B,MarioBuckel G,ErwinBrahm B,Javier Liver Cirrhosis, Bilary Liver Cirrhosis Background: Primary biliary cirrhosis (PBC) is a chronic cholestatic disease, which can progress to hepatic failure. Aim: To study the clinical presentation, pathological features, treatment and outcome of a group of patients with PBC. Material and methods: Retrospective review of medical records of 115 patients (110 females, age range 30-76 years) with PBC. Clinical presentation, pathological stage, treatment, outcome and eventual use of liver transplantation, were recorded. Result: Seventy eight percent of patients were symptomatic at presentation (itching in 69% and malaise in 62%). Antimitochondrial antibodies were positive in 56%. No clinical or laboratory differences were observed between symptomatic patients or those with positive antimitochondrial antibodies and the rest of the study group. Sjögren syndrome was present in 38%, hypothyroidism in 13%, scleroderma in 7% and rheumatoid arthritis in 5%. Initially, 61% had fibrosis and/or cirrhosis, and ursodeoxycholic acid was indicated in 94% of the patients. Fifteen patients underwent liver transplantation due to upper digestive bleeding or itching. Survival has been 67% at 36 months after transplantation. In one transplanted liver, PBC recurred. Conclusions: An early diagnosis and treatment of a progressive disease such as PBC will reduce the incidence of complications and the use of costly treatmentsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.4 20062006-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400010es10.4067/S0034-98872006000400010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Liver Cirrhosis, Bilary Liver Cirrhosis
spellingShingle	Liver Cirrhosis, Bilary Liver Cirrhosis Valera M,José Miguel Smok S,Gladys Poniachik T,Jaime Oksenberg R,Danny Silva P,Guillermo Ferrario B,Mario Buckel G,Erwin Brahm B,Javier Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
description	Background: Primary biliary cirrhosis (PBC) is a chronic cholestatic disease, which can progress to hepatic failure. Aim: To study the clinical presentation, pathological features, treatment and outcome of a group of patients with PBC. Material and methods: Retrospective review of medical records of 115 patients (110 females, age range 30-76 years) with PBC. Clinical presentation, pathological stage, treatment, outcome and eventual use of liver transplantation, were recorded. Result: Seventy eight percent of patients were symptomatic at presentation (itching in 69% and malaise in 62%). Antimitochondrial antibodies were positive in 56%. No clinical or laboratory differences were observed between symptomatic patients or those with positive antimitochondrial antibodies and the rest of the study group. Sjögren syndrome was present in 38%, hypothyroidism in 13%, scleroderma in 7% and rheumatoid arthritis in 5%. Initially, 61% had fibrosis and/or cirrhosis, and ursodeoxycholic acid was indicated in 94% of the patients. Fifteen patients underwent liver transplantation due to upper digestive bleeding or itching. Survival has been 67% at 36 months after transplantation. In one transplanted liver, PBC recurred. Conclusions: An early diagnosis and treatment of a progressive disease such as PBC will reduce the incidence of complications and the use of costly treatments
author	Valera M,José Miguel Smok S,Gladys Poniachik T,Jaime Oksenberg R,Danny Silva P,Guillermo Ferrario B,Mario Buckel G,Erwin Brahm B,Javier
author_facet	Valera M,José Miguel Smok S,Gladys Poniachik T,Jaime Oksenberg R,Danny Silva P,Guillermo Ferrario B,Mario Buckel G,Erwin Brahm B,Javier
author_sort	Valera M,José Miguel
title	Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
title_short	Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
title_full	Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
title_fullStr	Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
title_full_unstemmed	Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
title_sort	cirrosis biliar primaria: experiencia de trece años en dos centros de referencia
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400010
work_keys_str_mv	AT valeramjosemiguel cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia AT smoksgladys cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia AT poniachiktjaime cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia AT oksenbergrdanny cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia AT silvapguillermo cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia AT ferrariobmario cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia AT buckelgerwin cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia AT brahmbjavier cirrosisbiliarprimariaexperienciadetreceanosendoscentrosdereferencia
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Cirrosis biliar primaria: experiencia de trece años en dos centros de referencia

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