Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos

Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development of non-invasive molecular techniques that identify genetic variants in human b...

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Autores principales:	Quiñones,Luis, Lee,Kuen, Varela F,Nelson, Escala,Mario, García,Karen, Godoy,Loreto, Castro,Andrés, Soto,Jorge, Saavedra,Iván, Cáceres,Dante
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Neoplastic processes Pharmacogenetics Toxicogenetics Xenobiotics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400015
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spelling	oai:scielo:S0034-988720060004000152014-01-23Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticosQuiñones,LuisLee,KuenVarela F,NelsonEscala,MarioGarcía,KarenGodoy,LoretoCastro,AndrésSoto,JorgeSaavedra,IvánCáceres,Dante Neoplastic processes Pharmacogenetics Toxicogenetics Xenobiotics Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development of non-invasive molecular techniques that identify genetic variants in human beings. There is also a need to explain the individual differences in susceptibility to drug actions and disease risk. Genetic variants can modify the magnitude of a pharmacologic effect, toxicity threshold, secondary effects and drug interactions. There are approximately thirty families of drug-metabolizing enzymes with genetic variants that cause functional alterations and variations in pharmacologic activity. We summarize the general knowledge about genetic variants of biotransformation enzymes, their relationship with cancer risk and the role of ethnicity. Cancer pharmacogenetics is another promising and exciting research area that will explain why people with an almost identical group of genes, have a different susceptibility to cancer, whose etiology has genetic and environmental componentsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.4 20062006-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400015es10.4067/S0034-98872006000400015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Neoplastic processes Pharmacogenetics Toxicogenetics Xenobiotics
spellingShingle	Neoplastic processes Pharmacogenetics Toxicogenetics Xenobiotics Quiñones,Luis Lee,Kuen Varela F,Nelson Escala,Mario García,Karen Godoy,Loreto Castro,Andrés Soto,Jorge Saavedra,Iván Cáceres,Dante Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
description	Pharmacogenetics is the study of genetically determined variations in the response to drugs and toxic agents, and their implications on disease. Recently, the discipline has acquired great relevancy due to the development of non-invasive molecular techniques that identify genetic variants in human beings. There is also a need to explain the individual differences in susceptibility to drug actions and disease risk. Genetic variants can modify the magnitude of a pharmacologic effect, toxicity threshold, secondary effects and drug interactions. There are approximately thirty families of drug-metabolizing enzymes with genetic variants that cause functional alterations and variations in pharmacologic activity. We summarize the general knowledge about genetic variants of biotransformation enzymes, their relationship with cancer risk and the role of ethnicity. Cancer pharmacogenetics is another promising and exciting research area that will explain why people with an almost identical group of genes, have a different susceptibility to cancer, whose etiology has genetic and environmental components
author	Quiñones,Luis Lee,Kuen Varela F,Nelson Escala,Mario García,Karen Godoy,Loreto Castro,Andrés Soto,Jorge Saavedra,Iván Cáceres,Dante
author_facet	Quiñones,Luis Lee,Kuen Varela F,Nelson Escala,Mario García,Karen Godoy,Loreto Castro,Andrés Soto,Jorge Saavedra,Iván Cáceres,Dante
author_sort	Quiñones,Luis
title	Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
title_short	Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
title_full	Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
title_fullStr	Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
title_full_unstemmed	Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
title_sort	famacogénica del cáncer: estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000400015
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Famacogénica del cáncer: Estudio de variaciones genéticamente determinadas en la susceptibilidad a cáncer por exposición a xenobióticos

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