Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico

Primary and secondary prevention trials have clearly demonstrated that lowering serum cholesterol levels with statins reduces the incidence of cardiovascular events. Recent studies plus post hoc analysis of previous clinical trials show that risk reduction is proportional to the magnitude of LDL cho...

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Autores principales:	Rigotti R,Attilio, Arteaga Ll,Antonio, Maiz G,Alberto
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Hydroxymethylglutaryl-CoA reductase inhibitors Hypercholesterolemia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000500014
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spelling	oai:scielo:S0034-988720060005000142006-06-22Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroescleróticoRigotti R,AttilioArteaga Ll,AntonioMaiz G,Alberto Hydroxymethylglutaryl-CoA reductase inhibitors Hypercholesterolemia Primary and secondary prevention trials have clearly demonstrated that lowering serum cholesterol levels with statins reduces the incidence of cardiovascular events. Recent studies plus post hoc analysis of previous clinical trials show that risk reduction is proportional to the magnitude of LDL cholesterol lowering. Therefore, new recommendations of the National Cholesterol Education Program (USA) have defined a category of patients with very high cardiovascular risk, who should achieve serum LDL cholesterol levels below 70 mg/dl. This proposal will require new and more efficient pharmacologic strategies to attain the increasingly strict therapeutic goals for LDL cholesterol. This article reviews the clinical studies that support the use of intensive lipid lowering therapy to reduce cardiovascular risk. An effective reduction of serum cholesterol can be obtained using statins in high doses or a combination of hypolipidemic drugs with different mechanisms of actioninfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.5 20062006-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000500014es10.4067/S0034-98872006000500014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hydroxymethylglutaryl-CoA reductase inhibitors Hypercholesterolemia
spellingShingle	Hydroxymethylglutaryl-CoA reductase inhibitors Hypercholesterolemia Rigotti R,Attilio Arteaga Ll,Antonio Maiz G,Alberto Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico
description	Primary and secondary prevention trials have clearly demonstrated that lowering serum cholesterol levels with statins reduces the incidence of cardiovascular events. Recent studies plus post hoc analysis of previous clinical trials show that risk reduction is proportional to the magnitude of LDL cholesterol lowering. Therefore, new recommendations of the National Cholesterol Education Program (USA) have defined a category of patients with very high cardiovascular risk, who should achieve serum LDL cholesterol levels below 70 mg/dl. This proposal will require new and more efficient pharmacologic strategies to attain the increasingly strict therapeutic goals for LDL cholesterol. This article reviews the clinical studies that support the use of intensive lipid lowering therapy to reduce cardiovascular risk. An effective reduction of serum cholesterol can be obtained using statins in high doses or a combination of hypolipidemic drugs with different mechanisms of action
author	Rigotti R,Attilio Arteaga Ll,Antonio Maiz G,Alberto
author_facet	Rigotti R,Attilio Arteaga Ll,Antonio Maiz G,Alberto
author_sort	Rigotti R,Attilio
title	Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico
title_short	Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico
title_full	Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico
title_fullStr	Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico
title_full_unstemmed	Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico
title_sort	terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000500014
work_keys_str_mv	AT rigottirattilio terapiahipolepemianteintensivaenelmanejodelriesgocardiovascularateroesclerotico AT arteagallantonio terapiahipolepemianteintensivaenelmanejodelriesgocardiovascularateroesclerotico AT maizgalberto terapiahipolepemianteintensivaenelmanejodelriesgocardiovascularateroesclerotico
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Terapia hipolepemiante intensiva en el manejo del riesgo cardiovascular ateroesclerótico

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