Estrés oxidativo en el paciente crítico

Among critically ill patients, several physio-pathological processes such as global and local hypo-perfusion, hypoxia, endothelial injury and acidosis have been associated with the production and release of large amounts of reactive oxygen species (ROS) in a non regulated fashion. Although in physio...

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Autores principales:	Andresen H,Max, Regueira H,Tomás, Leighton,Federico
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Multiple organ failure Oxidative stress Reactive oxygen specias
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000500015
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spelling	oai:scielo:S0034-988720060005000152006-06-22Estrés oxidativo en el paciente críticoAndresen H,MaxRegueira H,TomásLeighton,Federico Multiple organ failure Oxidative stress Reactive oxygen specias Among critically ill patients, several physio-pathological processes such as global and local hypo-perfusion, hypoxia, endothelial injury and acidosis have been associated with the production and release of large amounts of reactive oxygen species (ROS) in a non regulated fashion. Although in physiologic conditions ROS influence intracellular processes and participate in the defense against infectious organism, in critically ill conditions they are associated with potential oxidative damage over cellular structures and with persistent activation of the inflammatory response. Mechanisms associated with oxidative damage are activation of the macrophage-monocyte system and neutrophils, ischemia-reperfusion events and intracellular ROS production. Endogenous compounds, mainly enzymes, and dietary components act as antioxidant. Several studies show that in critically ill patients increase levels of ROS or reduction of antioxidant levels are related to disease severity. In animal models of critical diseases, antioxidant therapy has shown to reduce mortality. Nevertheless, there are few studies in humans that only show improvements in hemodynamic variables, reduction in inflammatory mediators levels, decreases in oxidized compounds and that suggest a lower incidence of multiple organ failureinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.5 20062006-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000500015es10.4067/S0034-98872006000500015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Multiple organ failure Oxidative stress Reactive oxygen specias
spellingShingle	Multiple organ failure Oxidative stress Reactive oxygen specias Andresen H,Max Regueira H,Tomás Leighton,Federico Estrés oxidativo en el paciente crítico
description	Among critically ill patients, several physio-pathological processes such as global and local hypo-perfusion, hypoxia, endothelial injury and acidosis have been associated with the production and release of large amounts of reactive oxygen species (ROS) in a non regulated fashion. Although in physiologic conditions ROS influence intracellular processes and participate in the defense against infectious organism, in critically ill conditions they are associated with potential oxidative damage over cellular structures and with persistent activation of the inflammatory response. Mechanisms associated with oxidative damage are activation of the macrophage-monocyte system and neutrophils, ischemia-reperfusion events and intracellular ROS production. Endogenous compounds, mainly enzymes, and dietary components act as antioxidant. Several studies show that in critically ill patients increase levels of ROS or reduction of antioxidant levels are related to disease severity. In animal models of critical diseases, antioxidant therapy has shown to reduce mortality. Nevertheless, there are few studies in humans that only show improvements in hemodynamic variables, reduction in inflammatory mediators levels, decreases in oxidized compounds and that suggest a lower incidence of multiple organ failure
author	Andresen H,Max Regueira H,Tomás Leighton,Federico
author_facet	Andresen H,Max Regueira H,Tomás Leighton,Federico
author_sort	Andresen H,Max
title	Estrés oxidativo en el paciente crítico
title_short	Estrés oxidativo en el paciente crítico
title_full	Estrés oxidativo en el paciente crítico
title_fullStr	Estrés oxidativo en el paciente crítico
title_full_unstemmed	Estrés oxidativo en el paciente crítico
title_sort	estrés oxidativo en el paciente crítico
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000500015
work_keys_str_mv	AT andresenhmax estresoxidativoenelpacientecritico AT regueirahtomas estresoxidativoenelpacientecritico AT leightonfederico estresoxidativoenelpacientecritico
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Estrés oxidativo en el paciente crítico

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