Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?

Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?

Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Dopamine deficit is the cornerstone of its clinical manifestations. Levodopa, the main treatment for this condition, was first used for PD more than 40 years ago and today it still is the most powerful tr...

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Autores principales: Juri C,Carlos, Chaná C,Pedro
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2006
Materias:
Dopamine
Levodopa
Parkinson disease
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000700014
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spelling oai:scielo:S0034-988720060007000142006-08-29Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?Juri C,CarlosChaná C,Pedro Dopamine Levodopa Parkinson disease Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Dopamine deficit is the cornerstone of its clinical manifestations. Levodopa, the main treatment for this condition, was first used for PD more than 40 years ago and today it still is the most powerful treatment for this disease. In recent years many advances have been made for understanding of the neurochemical mechanisms of this drug. Furthermore, new insights about the genesis of motor complications secondary to its use are known, specially related with the mode of its administration. This article updates the pharmacology of levodopa and its implications for the pathophysiology and treatment of PD. The new available presentations of levodopa are also reviewed. The implications of these advances for the treatment of this disease are commentedinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.7 20062006-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000700014es10.4067/S0034-98872006000700014
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Dopamine
Levodopa
Parkinson disease
spellingShingle Dopamine
Levodopa
Parkinson disease
Juri C,Carlos
Chaná C,Pedro
Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?
description Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Dopamine deficit is the cornerstone of its clinical manifestations. Levodopa, the main treatment for this condition, was first used for PD more than 40 years ago and today it still is the most powerful treatment for this disease. In recent years many advances have been made for understanding of the neurochemical mechanisms of this drug. Furthermore, new insights about the genesis of motor complications secondary to its use are known, specially related with the mode of its administration. This article updates the pharmacology of levodopa and its implications for the pathophysiology and treatment of PD. The new available presentations of levodopa are also reviewed. The implications of these advances for the treatment of this disease are commented
author Juri C,Carlos
Chaná C,Pedro
author_facet Juri C,Carlos
Chaná C,Pedro
author_sort Juri C,Carlos
title Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?
title_short Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?
title_full Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?
title_fullStr Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?
title_full_unstemmed Levodopa en la enfermedad de Parkinson: ¿Qué hemos aprendido?
title_sort levodopa en la enfermedad de parkinson: ¿qué hemos aprendido?
publisher Sociedad Médica de Santiago
publishDate 2006
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000700014
work_keys_str_mv AT juriccarlos levodopaenlaenfermedaddeparkinsonquehemosaprendido
AT chanacpedro levodopaenlaenfermedaddeparkinsonquehemosaprendido
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