Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa

Background: The diagnosis of inflammatory bowel disease is supported by clinical findings and complementary tests. The presence of specific serological markers could be helpful in the characterization of this condition. Aim: To assess the prevalence of ANCA and ASCA in a group of patients with ulcer...

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Autores principales:	Vergara A,Teresa, Cofré L,Pamela, Cifuentes A,Soledad, Pulgar A,Ursula, Puebla A,Claudio, Velasco P,Susana
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Antibodies, antineutrophil cytoplasmic Colitis, ulcerative Saccharomyces cerevisiae)
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000800003
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spelling	oai:scielo:S0034-988720060008000032014-01-23Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosaVergara A,TeresaCofré L,PamelaCifuentes A,SoledadPulgar A,UrsulaPuebla A,ClaudioVelasco P,Susana Antibodies, antineutrophil cytoplasmic Colitis, ulcerative Saccharomyces cerevisiae) Background: The diagnosis of inflammatory bowel disease is supported by clinical findings and complementary tests. The presence of specific serological markers could be helpful in the characterization of this condition. Aim: To assess the prevalence of ANCA and ASCA in a group of patients with ulcerative colitis (UC) and its association with clinical features. Material and Methods: Sixty four patients with UC in remission (age range 16-72 years, 33 males) were studied. In a venous blood sample ANCA were measured by indirect immunofluorescence and ASCA by enzyme immune assays for IgG and IgA. Results: Forty four percent of patients were positive for ANCA, 9% for ASCA and 6% for both markers. There was a significant correlation between the presence of ANCA and duration of the UC (<5 years 50%, 5-10 years 42.9%, 15 years 30%) and the number of crises (one crises 31%, 2-5 crises 51.9% and >5 crises 87.5). The proportion of colectomized patients with positive ANCA was higher (57.1%). Conclusions: The prevalence of ANCA in the studied population is similar to the published data. The presence of ANCA was significantly higher in UC patients with shorter evolution, higher number of crises and in those with a history of colectomy. There was a low prevalence of ASCA positive patients (Rev Méd Chile 2006; 134: 960-4).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.8 20062006-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000800003es10.4067/S0034-98872006000800003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antibodies, antineutrophil cytoplasmic Colitis, ulcerative Saccharomyces cerevisiae)
spellingShingle	Antibodies, antineutrophil cytoplasmic Colitis, ulcerative Saccharomyces cerevisiae) Vergara A,Teresa Cofré L,Pamela Cifuentes A,Soledad Pulgar A,Ursula Puebla A,Claudio Velasco P,Susana Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa
description	Background: The diagnosis of inflammatory bowel disease is supported by clinical findings and complementary tests. The presence of specific serological markers could be helpful in the characterization of this condition. Aim: To assess the prevalence of ANCA and ASCA in a group of patients with ulcerative colitis (UC) and its association with clinical features. Material and Methods: Sixty four patients with UC in remission (age range 16-72 years, 33 males) were studied. In a venous blood sample ANCA were measured by indirect immunofluorescence and ASCA by enzyme immune assays for IgG and IgA. Results: Forty four percent of patients were positive for ANCA, 9% for ASCA and 6% for both markers. There was a significant correlation between the presence of ANCA and duration of the UC (<5 years 50%, 5-10 years 42.9%, 15 years 30%) and the number of crises (one crises 31%, 2-5 crises 51.9% and >5 crises 87.5). The proportion of colectomized patients with positive ANCA was higher (57.1%). Conclusions: The prevalence of ANCA in the studied population is similar to the published data. The presence of ANCA was significantly higher in UC patients with shorter evolution, higher number of crises and in those with a history of colectomy. There was a low prevalence of ASCA positive patients (Rev Méd Chile 2006; 134: 960-4).
author	Vergara A,Teresa Cofré L,Pamela Cifuentes A,Soledad Pulgar A,Ursula Puebla A,Claudio Velasco P,Susana
author_facet	Vergara A,Teresa Cofré L,Pamela Cifuentes A,Soledad Pulgar A,Ursula Puebla A,Claudio Velasco P,Susana
author_sort	Vergara A,Teresa
title	Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa
title_short	Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa
title_full	Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa
title_fullStr	Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa
title_full_unstemmed	Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa
title_sort	prevalencia de marcadores serológicos anca y asca en una población con colitis ulcerosa
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000800003
work_keys_str_mv	AT vergaraateresa prevalenciademarcadoresserologicosancayascaenunapoblacionconcolitisulcerosa AT cofrelpamela prevalenciademarcadoresserologicosancayascaenunapoblacionconcolitisulcerosa AT cifuentesasoledad prevalenciademarcadoresserologicosancayascaenunapoblacionconcolitisulcerosa AT pulgaraursula prevalenciademarcadoresserologicosancayascaenunapoblacionconcolitisulcerosa AT pueblaaclaudio prevalenciademarcadoresserologicosancayascaenunapoblacionconcolitisulcerosa AT velascopsusana prevalenciademarcadoresserologicosancayascaenunapoblacionconcolitisulcerosa
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Prevalencia de marcadores serológicos ANCA y ASCA en una población con colitis ulcerosa

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