Barrera intestinal del paciente crítico: realidades y tendencias

The disturbances of gut barrier in critically ill patients may influence their outcome and prognosis. Experiments in animals show that fasting and stress collaborate to produce intestinal atrophy and translocation of microorganisms and toxins. This fact is one of the main arguments to promote the us...

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Autor principal:	Velasco F,Nicolás
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Bacterial translocation Critical illness Gut barrier Intestinal mucosa
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000800014
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spelling	oai:scielo:S0034-988720060008000142014-01-23Barrera intestinal del paciente crítico: realidades y tendenciasVelasco F,Nicolás Bacterial translocation Critical illness Gut barrier Intestinal mucosa The disturbances of gut barrier in critically ill patients may influence their outcome and prognosis. Experiments in animals show that fasting and stress collaborate to produce intestinal atrophy and translocation of microorganisms and toxins. This fact is one of the main arguments to promote the use of early enteral feeding in critically ill patients. However, the intestinal barrier behaves differently in humans than in animals. The human enteral cells have a good tolerance to fasting and stress, mucosal atrophy is mild and it is not always associated with changes in intestinal permeability. Moreover, the relationship between intestinal permeability with sepsis and bacterial translocation is controversial. This last phenomenon also happens in normal subjects and may be a mechanism to build immunological memory. One of the most important factors that influence bacterial translocation is the microorganism, that under stress conditions can adhere to the intestinal cell and penetrate the intestinal barrier. Splanchnic ischemia and reperfusion is one of the main pathogenic factors in the failure of intestinal barrier. Finally, the fact that the small bowel is an inflammatory target of extra intestinal injuries, explains several clinical situations. The pathophysiology of the intestinal barrier definitely requires more research (Rev Méd Chile 2006; 134: 1033-39).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.8 20062006-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000800014es10.4067/S0034-98872006000800014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Bacterial translocation Critical illness Gut barrier Intestinal mucosa
spellingShingle	Bacterial translocation Critical illness Gut barrier Intestinal mucosa Velasco F,Nicolás Barrera intestinal del paciente crítico: realidades y tendencias
description	The disturbances of gut barrier in critically ill patients may influence their outcome and prognosis. Experiments in animals show that fasting and stress collaborate to produce intestinal atrophy and translocation of microorganisms and toxins. This fact is one of the main arguments to promote the use of early enteral feeding in critically ill patients. However, the intestinal barrier behaves differently in humans than in animals. The human enteral cells have a good tolerance to fasting and stress, mucosal atrophy is mild and it is not always associated with changes in intestinal permeability. Moreover, the relationship between intestinal permeability with sepsis and bacterial translocation is controversial. This last phenomenon also happens in normal subjects and may be a mechanism to build immunological memory. One of the most important factors that influence bacterial translocation is the microorganism, that under stress conditions can adhere to the intestinal cell and penetrate the intestinal barrier. Splanchnic ischemia and reperfusion is one of the main pathogenic factors in the failure of intestinal barrier. Finally, the fact that the small bowel is an inflammatory target of extra intestinal injuries, explains several clinical situations. The pathophysiology of the intestinal barrier definitely requires more research (Rev Méd Chile 2006; 134: 1033-39).
author	Velasco F,Nicolás
author_facet	Velasco F,Nicolás
author_sort	Velasco F,Nicolás
title	Barrera intestinal del paciente crítico: realidades y tendencias
title_short	Barrera intestinal del paciente crítico: realidades y tendencias
title_full	Barrera intestinal del paciente crítico: realidades y tendencias
title_fullStr	Barrera intestinal del paciente crítico: realidades y tendencias
title_full_unstemmed	Barrera intestinal del paciente crítico: realidades y tendencias
title_sort	barrera intestinal del paciente crítico: realidades y tendencias
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000800014
work_keys_str_mv	AT velascofnicolas barreraintestinaldelpacientecriticorealidadesytendencias
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Barrera intestinal del paciente crítico: realidades y tendencias

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