Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico

Background: In Chile, flour is fortified with folic acid since 2000, and the incidence of neural tube defects has decreased. Cranio-encephalic congenital defects (CECD) have a wider clinical scope, includind classical neural tube defects (NTD) such as anencephalia and acrania, but also incorporating...

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Autores principales:	Corral S,Edgardo, Moreno S,Rodrigo, Pérez G,Guillermo, Ojeda B,María Elena, Valenzuela G,Hernán, Reascos M,Mauricio, Sepúlveda L,Waldo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Dietary supplements Flour Folic acid Nervous system malformations
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900007
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spelling	oai:scielo:S0034-988720060009000072014-01-23Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólicoCorral S,EdgardoMoreno S,RodrigoPérez G,GuillermoOjeda B,María ElenaValenzuela G,HernánReascos M,MauricioSepúlveda L,Waldo Dietary supplements Flour Folic acid Nervous system malformations Background: In Chile, flour is fortified with folic acid since 2000, and the incidence of neural tube defects has decreased. Cranio-encephalic congenital defects (CECD) have a wider clinical scope, includind classical neural tube defects (NTD) such as anencephalia and acrania, but also incorporating other defects. Therefore, the effects of folic acid fortification on the incidence of CECD could be different. Aim: To study the effect of folic acid fortification on the incidence of CECD. Material and methods: All prenatal diagnoses of CECD and cases registered locally in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were reviewed. The obtained data were crossed with all death certificates of newborns or stillborns of more than 500 g in the Sixth Region, in Central Chile. All cases were classified again in four subtypes, according to their phenotype. The incidences of all subtypes prior (1996-2000) and after folic acid supplementation (2001-2004), were compared. Results: Between 1996 and 2004, there were 64 cases of CEDC among 109,176 infants born alive. The global rate was 8.86 per 10,000 born alive in the period prior to fortification and 3.03 per 10,000 born alive after fortification. Comparing both periods, there was a 66% reduction in all CECD and a 77 and 100% reduction in subtypes A and B of CECD, respectively (p <0.05). No significant reductions in type C and D CECD, were observed. Conclusions: After the start of flour folic acid fortification, there was a global reduction in the incidence of CECD. However, only types A and B CECD, supposedly more responsive to folic acid, were reducedinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.9 20062006-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900007es10.4067/S0034-98872006000900007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Dietary supplements Flour Folic acid Nervous system malformations
spellingShingle	Dietary supplements Flour Folic acid Nervous system malformations Corral S,Edgardo Moreno S,Rodrigo Pérez G,Guillermo Ojeda B,María Elena Valenzuela G,Hernán Reascos M,Mauricio Sepúlveda L,Waldo Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
description	Background: In Chile, flour is fortified with folic acid since 2000, and the incidence of neural tube defects has decreased. Cranio-encephalic congenital defects (CECD) have a wider clinical scope, includind classical neural tube defects (NTD) such as anencephalia and acrania, but also incorporating other defects. Therefore, the effects of folic acid fortification on the incidence of CECD could be different. Aim: To study the effect of folic acid fortification on the incidence of CECD. Material and methods: All prenatal diagnoses of CECD and cases registered locally in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) were reviewed. The obtained data were crossed with all death certificates of newborns or stillborns of more than 500 g in the Sixth Region, in Central Chile. All cases were classified again in four subtypes, according to their phenotype. The incidences of all subtypes prior (1996-2000) and after folic acid supplementation (2001-2004), were compared. Results: Between 1996 and 2004, there were 64 cases of CEDC among 109,176 infants born alive. The global rate was 8.86 per 10,000 born alive in the period prior to fortification and 3.03 per 10,000 born alive after fortification. Comparing both periods, there was a 66% reduction in all CECD and a 77 and 100% reduction in subtypes A and B of CECD, respectively (p <0.05). No significant reductions in type C and D CECD, were observed. Conclusions: After the start of flour folic acid fortification, there was a global reduction in the incidence of CECD. However, only types A and B CECD, supposedly more responsive to folic acid, were reduced
author	Corral S,Edgardo Moreno S,Rodrigo Pérez G,Guillermo Ojeda B,María Elena Valenzuela G,Hernán Reascos M,Mauricio Sepúlveda L,Waldo
author_facet	Corral S,Edgardo Moreno S,Rodrigo Pérez G,Guillermo Ojeda B,María Elena Valenzuela G,Hernán Reascos M,Mauricio Sepúlveda L,Waldo
author_sort	Corral S,Edgardo
title	Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
title_short	Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
title_full	Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
title_fullStr	Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
title_full_unstemmed	Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
title_sort	defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900007
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Defectos congénitos cráneo-encefálicos: variedades y respuesta a la fortificación de la harina con ácido fólico

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