Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico

Biphosphonates reduce the risk of skeletal events and are currently part of standards of therapy in myeloma. Recently, zoledronate and pamidronate have been linked to osteonecrosis of the jaw, specially after surgical dental procedures. We report a 84 year-old man with multiple myeloma who developed...

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Autores principales:	Anguita C,Timoleón, Agurto P,Jaime, Roa E,Iván, Laissle C,German
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Diphosphonates Myeloma Zoledronic acid
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900011
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spelling	oai:scielo:S0034-988720060009000112014-01-23Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínicoAnguita C,TimoleónAgurto P,JaimeRoa E,IvánLaissle C,German Diphosphonates Myeloma Zoledronic acid Biphosphonates reduce the risk of skeletal events and are currently part of standards of therapy in myeloma. Recently, zoledronate and pamidronate have been linked to osteonecrosis of the jaw, specially after surgical dental procedures. We report a 84 year-old man with multiple myeloma who developed spontaneous osteonecrosis of both jaws, after 36 months of therapy with zoledronate with a cumulative dose of 136 mg. We discuss the pathogenic mechanisms, and review the recommendations on prevention and management of this new complication for neoplastic patients under prolonged therapy with biphosphonatesinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.9 20062006-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900011es10.4067/S0034-98872006000900011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diphosphonates Myeloma Zoledronic acid
spellingShingle	Diphosphonates Myeloma Zoledronic acid Anguita C,Timoleón Agurto P,Jaime Roa E,Iván Laissle C,German Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico
description	Biphosphonates reduce the risk of skeletal events and are currently part of standards of therapy in myeloma. Recently, zoledronate and pamidronate have been linked to osteonecrosis of the jaw, specially after surgical dental procedures. We report a 84 year-old man with multiple myeloma who developed spontaneous osteonecrosis of both jaws, after 36 months of therapy with zoledronate with a cumulative dose of 136 mg. We discuss the pathogenic mechanisms, and review the recommendations on prevention and management of this new complication for neoplastic patients under prolonged therapy with biphosphonates
author	Anguita C,Timoleón Agurto P,Jaime Roa E,Iván Laissle C,German
author_facet	Anguita C,Timoleón Agurto P,Jaime Roa E,Iván Laissle C,German
author_sort	Anguita C,Timoleón
title	Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico
title_short	Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico
title_full	Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico
title_fullStr	Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico
title_full_unstemmed	Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico
title_sort	osteonecrosis asociada al uso de bifosfonatos: a propósito de un caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900011
work_keys_str_mv	AT anguitactimoleon osteonecrosisasociadaalusodebifosfonatosapropositodeuncasoclinico AT agurtopjaime osteonecrosisasociadaalusodebifosfonatosapropositodeuncasoclinico AT roaeivan osteonecrosisasociadaalusodebifosfonatosapropositodeuncasoclinico AT laisslecgerman osteonecrosisasociadaalusodebifosfonatosapropositodeuncasoclinico
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Osteonecrosis asociada al uso de bifosfonatos: A propósito de un caso clínico

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