BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide

BAFF (B cell activating factor belonging to the TNF family) is a cytokine implicated in the survival and maturation of peripheral B lymphocytes and T and B cell activation. BAFF binds to three different receptors: TACI, BCMA and BAFF-R, whose expression is restricted to B and T lymphocytes. BAFF and...

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Autores principales:	Reyes S,Lilian I, León B,Francisca, Rozas V,M Fernanda, González J,Patricia, Naves P,Rodrigo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Autoimmunity B cell activating factors Cytokines
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900014
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spelling	oai:scielo:S0034-988720060009000142014-01-23BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoideReyes S,Lilian ILeón B,FranciscaRozas V,M FernandaGonzález J,PatriciaNaves P,Rodrigo Autoimmunity B cell activating factors Cytokines BAFF (B cell activating factor belonging to the TNF family) is a cytokine implicated in the survival and maturation of peripheral B lymphocytes and T and B cell activation. BAFF binds to three different receptors: TACI, BCMA and BAFF-R, whose expression is restricted to B and T lymphocytes. BAFF and BAFF-R-deficient mice show a dramatic loss of peripheral B lymphocytes and a severely reduced immune response. In contrast, an enhanced BAFF expression leads to B cell hyperplasia and autoimmunity in mice. In vivo, administration of soluble decoy receptors for BAFF effectively decreases disease progression in various autoimmune mouse models. These evidences render BAFF as a potentially new therapeutic target. Elevated BAFF levels have been detected in the serum of patients with autoimmune diseases, such as Systemic Lupus Erythematosus, rheumatoid arthitis, Sjögren's syndrome, lymphoid cancers and HIV infection. In addition to BAFF receptors, malignant B cells abnormally express BAFF, which attenuates apoptosis through both autocrine and paracrine pathways. The data suggest that an increase in the expression of BAFF induces an enhanced B and T cell activation and the survival of pathologically active B cells. In this article, we review and discuss the participation of BAFF and its receptors in the immune response and its involvement in immunodeficiency, autoimmunity, infections and lymphoid cancers as well as the currently investigated therapies using BAFF antagonists in the treatment of these diseasesinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.9 20062006-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900014es10.4067/S0034-98872006000900014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Autoimmunity B cell activating factors Cytokines
spellingShingle	Autoimmunity B cell activating factors Cytokines Reyes S,Lilian I León B,Francisca Rozas V,M Fernanda González J,Patricia Naves P,Rodrigo BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
description	BAFF (B cell activating factor belonging to the TNF family) is a cytokine implicated in the survival and maturation of peripheral B lymphocytes and T and B cell activation. BAFF binds to three different receptors: TACI, BCMA and BAFF-R, whose expression is restricted to B and T lymphocytes. BAFF and BAFF-R-deficient mice show a dramatic loss of peripheral B lymphocytes and a severely reduced immune response. In contrast, an enhanced BAFF expression leads to B cell hyperplasia and autoimmunity in mice. In vivo, administration of soluble decoy receptors for BAFF effectively decreases disease progression in various autoimmune mouse models. These evidences render BAFF as a potentially new therapeutic target. Elevated BAFF levels have been detected in the serum of patients with autoimmune diseases, such as Systemic Lupus Erythematosus, rheumatoid arthitis, Sjögren's syndrome, lymphoid cancers and HIV infection. In addition to BAFF receptors, malignant B cells abnormally express BAFF, which attenuates apoptosis through both autocrine and paracrine pathways. The data suggest that an increase in the expression of BAFF induces an enhanced B and T cell activation and the survival of pathologically active B cells. In this article, we review and discuss the participation of BAFF and its receptors in the immune response and its involvement in immunodeficiency, autoimmunity, infections and lymphoid cancers as well as the currently investigated therapies using BAFF antagonists in the treatment of these diseases
author	Reyes S,Lilian I León B,Francisca Rozas V,M Fernanda González J,Patricia Naves P,Rodrigo
author_facet	Reyes S,Lilian I León B,Francisca Rozas V,M Fernanda González J,Patricia Naves P,Rodrigo
author_sort	Reyes S,Lilian I
title	BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
title_short	BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
title_full	BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
title_fullStr	BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
title_full_unstemmed	BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide
title_sort	baff: una citoquina reguladora de linfocitos b implicada en autoinmunidad y cáncer linfoide
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006000900014
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BAFF: Una citoquina reguladora de linfocitos B implicada en autoinmunidad y cáncer linfoide

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