Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio

Background: The optimal dose of Streptokinase in the treatment of acute myocardial infarction is not well established. Apparently, the thrombolytic efficacy would not increase with doses over 750.000 units. Aim: To compare the effectiveness and safety of treatment with low doses of Streptokinase, ra...

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Autores principales:	Raffo G,Carlos, Bartolucci J,Jorge, Corbalán H,Ramón, Aninat H,Mauricio, Torres H,Humberto, Prieto D,Juan Carlos, Lanas Z,Fernando, Chávez S,Eduardo, Cumsille G,Francisco, Nazzal N,Carolina
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Myocardial infarction Streptokinase Thrombolytic therapy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001000006
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spelling	oai:scielo:S0034-988720060010000062006-12-28Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardioRaffo G,CarlosBartolucci J,JorgeCorbalán H,RamónAninat H,MauricioTorres H,HumbertoPrieto D,Juan CarlosLanas Z,FernandoChávez S,EduardoCumsille G,FranciscoNazzal N,Carolina Myocardial infarction Streptokinase Thrombolytic therapy Background: The optimal dose of Streptokinase in the treatment of acute myocardial infarction is not well established. Apparently, the thrombolytic efficacy would not increase with doses over 750.000 units. Aim: To compare the effectiveness and safety of treatment with low doses of Streptokinase, ranging from 500.000 to 750.000 units, in patients with ST elevation acute myocardial infarction. Patients and methods: From September 1993 to September 1998, the GEMI register of patients with acute myocardial infarction, was carried out in 37 hospitals, incorporating 4,938 patients. Of these, 1,631 patients received streptokinase. According to the administered dose of Streptokinase, patients were divided in two groups: 1,465 patients who received 1.5 millions U in 60 minutes (classical therapy group), and 166 patients with ischemic chest discomfort and either ST-segment elevation or left bundle-branch block on the electrocardiogram, who received 500.000 to 750.000 U streptokinase administered in no more than 30 minutes, with heparin, within 0 to 6 hours of symptom onset. Successful reperfusion, mortality, complications, and hospital outcome was evaluated in both groups. Results: The low dose group of patients had a better reperfusion criteria profile. No differences between groups were observed in patient evolution, mortality, maximum Killip classification, post myocardial infarction heart failure, ischemic complications, arrhythmias or mechanical complications. Conclusions: These results suggest that streptokinase in low doses is at least as effective as classical therapy, in the treatment of ST elevation acute myocardial infarctioninfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.10 20062006-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001000006es10.4067/S0034-98872006001000006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Myocardial infarction Streptokinase Thrombolytic therapy
spellingShingle	Myocardial infarction Streptokinase Thrombolytic therapy Raffo G,Carlos Bartolucci J,Jorge Corbalán H,Ramón Aninat H,Mauricio Torres H,Humberto Prieto D,Juan Carlos Lanas Z,Fernando Chávez S,Eduardo Cumsille G,Francisco Nazzal N,Carolina Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio
description	Background: The optimal dose of Streptokinase in the treatment of acute myocardial infarction is not well established. Apparently, the thrombolytic efficacy would not increase with doses over 750.000 units. Aim: To compare the effectiveness and safety of treatment with low doses of Streptokinase, ranging from 500.000 to 750.000 units, in patients with ST elevation acute myocardial infarction. Patients and methods: From September 1993 to September 1998, the GEMI register of patients with acute myocardial infarction, was carried out in 37 hospitals, incorporating 4,938 patients. Of these, 1,631 patients received streptokinase. According to the administered dose of Streptokinase, patients were divided in two groups: 1,465 patients who received 1.5 millions U in 60 minutes (classical therapy group), and 166 patients with ischemic chest discomfort and either ST-segment elevation or left bundle-branch block on the electrocardiogram, who received 500.000 to 750.000 U streptokinase administered in no more than 30 minutes, with heparin, within 0 to 6 hours of symptom onset. Successful reperfusion, mortality, complications, and hospital outcome was evaluated in both groups. Results: The low dose group of patients had a better reperfusion criteria profile. No differences between groups were observed in patient evolution, mortality, maximum Killip classification, post myocardial infarction heart failure, ischemic complications, arrhythmias or mechanical complications. Conclusions: These results suggest that streptokinase in low doses is at least as effective as classical therapy, in the treatment of ST elevation acute myocardial infarction
author	Raffo G,Carlos Bartolucci J,Jorge Corbalán H,Ramón Aninat H,Mauricio Torres H,Humberto Prieto D,Juan Carlos Lanas Z,Fernando Chávez S,Eduardo Cumsille G,Francisco Nazzal N,Carolina
author_facet	Raffo G,Carlos Bartolucci J,Jorge Corbalán H,Ramón Aninat H,Mauricio Torres H,Humberto Prieto D,Juan Carlos Lanas Z,Fernando Chávez S,Eduardo Cumsille G,Francisco Nazzal N,Carolina
author_sort	Raffo G,Carlos
title	Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio
title_short	Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio
title_full	Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio
title_fullStr	Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio
title_full_unstemmed	Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio
title_sort	utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001000006
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Utilidad de la terapia trombolítica con estreptokinasa a dosis baja en infarto agudo del miocardio

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