Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad

Backgrounds: There is a high prevalence of obesity and hyperinsulinism among Chilean prepuberal children. Aim: To evaluate insulin sensitivity (IS) using fasting insulin, the Homeostasis Model Assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) in Chilean children. Material a...

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Autores principales:	Burrows A,Raquel, Leiva B,Laura, Burgueño A,Medardo, Maggi M,Aida, Giadrosic R,Vinka, Díaz B,Erick, Lera M,Lydia, Albala B,Cecilia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Homeostasis Insulin resistance Obesity Puberty
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001100009
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spelling	oai:scielo:S0034-988720060011000092014-01-24Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertadBurrows A,RaquelLeiva B,LauraBurgueño A,MedardoMaggi M,AidaGiadrosic R,VinkaDíaz B,ErickLera M,LydiaAlbala B,Cecilia Homeostasis Insulin resistance Obesity Puberty Backgrounds: There is a high prevalence of obesity and hyperinsulinism among Chilean prepuberal children. Aim: To evaluate insulin sensitivity (IS) using fasting insulin, the Homeostasis Model Assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) in Chilean children. Material and Methods: Body mass index (BMI), total body fat percentage (%TBF) using the sum of 4 skin folds, abdominal obesity determined through waist circumference (WC), pubertal maturation using five Tanner stages, fasting glucose (Glu) and insulin (Ins), were measured in 354 children aged 6 to 15 years (173 males). IS was evaluated using HOMA and QUICKI. Results: IS was strongly associated with %TBF and WC. Ins, HOMA and QUICKI were significantly correlated with BMI (r =0.412; 0.405 y -0.442, respectively), %TBF (r =0.370; 0.367 y -0.394, respectively), and WC (r =0.452; 0.446 y -0.481, respectively). Ins and HOMA increased and QUICKI decreased significantly (p <0.0001) with age. Children in a similar Tanner stage did not have differences in Ins, HOMA and QUICKI. No differences in Ins, HOMA and QUICKI were observed between children in Tanner stages 1 and 2. However, children in Tanner stages 1 and 2, had significantly lower Ins and HOMA and higher QUICKI than those in Tanner 3 to 5 stages. The highest Ins quartile for Tanner stages 1 and 2 was 10.0 µUI/dl; for Tanner stages 3 to five, the figure was 15.6 µUI/dl. Conclusions: These results confirm the relationship of IS with BMI, %TBF, WC and pubertal maturation. IS decreases significantly and fasting Ins levels increase approximately 50% with puberty. This fact must be considered for the diagnosis of hyperinsulinism and insulin resistance in childreninfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.11 20062006-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001100009es10.4067/S0034-98872006001100009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Homeostasis Insulin resistance Obesity Puberty
spellingShingle	Homeostasis Insulin resistance Obesity Puberty Burrows A,Raquel Leiva B,Laura Burgueño A,Medardo Maggi M,Aida Giadrosic R,Vinka Díaz B,Erick Lera M,Lydia Albala B,Cecilia Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
description	Backgrounds: There is a high prevalence of obesity and hyperinsulinism among Chilean prepuberal children. Aim: To evaluate insulin sensitivity (IS) using fasting insulin, the Homeostasis Model Assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) in Chilean children. Material and Methods: Body mass index (BMI), total body fat percentage (%TBF) using the sum of 4 skin folds, abdominal obesity determined through waist circumference (WC), pubertal maturation using five Tanner stages, fasting glucose (Glu) and insulin (Ins), were measured in 354 children aged 6 to 15 years (173 males). IS was evaluated using HOMA and QUICKI. Results: IS was strongly associated with %TBF and WC. Ins, HOMA and QUICKI were significantly correlated with BMI (r =0.412; 0.405 y -0.442, respectively), %TBF (r =0.370; 0.367 y -0.394, respectively), and WC (r =0.452; 0.446 y -0.481, respectively). Ins and HOMA increased and QUICKI decreased significantly (p <0.0001) with age. Children in a similar Tanner stage did not have differences in Ins, HOMA and QUICKI. No differences in Ins, HOMA and QUICKI were observed between children in Tanner stages 1 and 2. However, children in Tanner stages 1 and 2, had significantly lower Ins and HOMA and higher QUICKI than those in Tanner 3 to 5 stages. The highest Ins quartile for Tanner stages 1 and 2 was 10.0 µUI/dl; for Tanner stages 3 to five, the figure was 15.6 µUI/dl. Conclusions: These results confirm the relationship of IS with BMI, %TBF, WC and pubertal maturation. IS decreases significantly and fasting Ins levels increase approximately 50% with puberty. This fact must be considered for the diagnosis of hyperinsulinism and insulin resistance in children
author	Burrows A,Raquel Leiva B,Laura Burgueño A,Medardo Maggi M,Aida Giadrosic R,Vinka Díaz B,Erick Lera M,Lydia Albala B,Cecilia
author_facet	Burrows A,Raquel Leiva B,Laura Burgueño A,Medardo Maggi M,Aida Giadrosic R,Vinka Díaz B,Erick Lera M,Lydia Albala B,Cecilia
author_sort	Burrows A,Raquel
title	Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
title_short	Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
title_full	Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
title_fullStr	Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
title_full_unstemmed	Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
title_sort	sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001100009
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Sensibilidad insulínica en niños de 6 a 15 años: asociación con estado nutricional y pubertad

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