Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005

Background:There are some records shrowing that the frequency of Down syndrome is experiencing an increase over time. Aim: To verify whether the frequency of Down syndrome is increasing in the maternity of the University of Chile Clinical Hospital, or in other Chilean hospitals participating in the...

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Autores principales:	Nazer H,Julio, Aguila R,Alfredo, Cifuentes O,Lucía
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2006
Materias:	Down syndrome Maternal age Nervous system malformations
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001200009
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spelling	oai:scielo:S0034-988720060012000092007-01-24Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005Nazer H,JulioAguila R,AlfredoCifuentes O,Lucía Down syndrome Maternal age Nervous system malformations Background:There are some records shrowing that the frequency of Down syndrome is experiencing an increase over time. Aim: To verify whether the frequency of Down syndrome is increasing in the maternity of the University of Chile Clinical Hospital, or in other Chilean hospitals participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) and compare the rates with other world registries of congenital malformations. Material and methods: The information was obtained from the ECLAMC databases of the maternity. The Down syndrome incidence rates were calculated from 1997 to 2005 and rate curves were constructed. Results: The overall rate of Down syndrome was 3.36 per 10,000 born alive. This rate experienced a significant increase in the study period. These rates differ in the different Chilean regions, being higher in Santiago and lower in the Southern regions of the country. The mean age of mothers of newborns with or without Down syndrome was 36±6 and 29±6 years, respectively, p >0.001. Conclusions: The rates of newborns with Down syndrome increased in the period 1972-2005, bearing a close relationship with the increase in maternal ages/info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.134 n.12 20062006-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001200009es10.4067/S0034-98872006001200009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Down syndrome Maternal age Nervous system malformations
spellingShingle	Down syndrome Maternal age Nervous system malformations Nazer H,Julio Aguila R,Alfredo Cifuentes O,Lucía Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005
description	Background:There are some records shrowing that the frequency of Down syndrome is experiencing an increase over time. Aim: To verify whether the frequency of Down syndrome is increasing in the maternity of the University of Chile Clinical Hospital, or in other Chilean hospitals participating in the Latin American Collaborative Study of Congenital Malformations (ECLAMC) and compare the rates with other world registries of congenital malformations. Material and methods: The information was obtained from the ECLAMC databases of the maternity. The Down syndrome incidence rates were calculated from 1997 to 2005 and rate curves were constructed. Results: The overall rate of Down syndrome was 3.36 per 10,000 born alive. This rate experienced a significant increase in the study period. These rates differ in the different Chilean regions, being higher in Santiago and lower in the Southern regions of the country. The mean age of mothers of newborns with or without Down syndrome was 36±6 and 29±6 years, respectively, p >0.001. Conclusions: The rates of newborns with Down syndrome increased in the period 1972-2005, bearing a close relationship with the increase in maternal ages/
author	Nazer H,Julio Aguila R,Alfredo Cifuentes O,Lucía
author_facet	Nazer H,Julio Aguila R,Alfredo Cifuentes O,Lucía
author_sort	Nazer H,Julio
title	Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005
title_short	Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005
title_full	Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005
title_fullStr	Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005
title_full_unstemmed	Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005
title_sort	vigilancia epidemiológica del síndrome de down en chile, 1972 a 2005
publisher	Sociedad Médica de Santiago
publishDate	2006
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872006001200009
work_keys_str_mv	AT nazerhjulio vigilanciaepidemiologicadelsindromededownenchile1972a2005 AT aguilaralfredo vigilanciaepidemiologicadelsindromededownenchile1972a2005 AT cifuentesolucia vigilanciaepidemiologicadelsindromededownenchile1972a2005
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Vigilancia epidemiológica del síndrome de Down en Chile, 1972 a 2005

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