Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama

In the early stages of breast cancer, surgery and radiotherapy arrest the local and regional disease. However 30% of patients will die as a consequence of tumor dissemination. Parameters with a relative predictive value are used to assess candidates to adjuvant therapy. Genomic analysis methods (cDN...

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Autor principal:	Corvalán,Alejandro
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Breast neoplasms Chemotherapy, adjuvant Gene expression
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000200016
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spelling	oai:scielo:S0034-988720070002000162007-03-28Perfiles de expresión génica en decisiones terapéuticas en cáncer de mamaCorvalán,Alejandro Breast neoplasms Chemotherapy, adjuvant Gene expression In the early stages of breast cancer, surgery and radiotherapy arrest the local and regional disease. However 30% of patients will die as a consequence of tumor dissemination. Parameters with a relative predictive value are used to assess candidates to adjuvant therapy. Genomic analysis methods (cDNA microarray) identified a gene expression profile of greater aggressiveness in breast cancer. This knowledge generated the project "Translating Molecular Knowledge Into Early Breast Cancer Management" of the Breast International Group (BIG). This is a consortium of 32 research groups in which Chile participates through the Chilean Cooperative Oncological Research Group (GOCCHI). The project consists in three protocols. In the first, denomimated MINDACT (Microarray for Node Negative Disease may Avoid Chemotherapy), 8000 women will be evaluated by gene expression profile and clinical pathological criteria to decide adjuvant therapy. Since a group of patients will not receive therapy, solely based on gene expression profile, GOCCHI is preparing a follow up protocol based on the expression of 22 genes. MINDACT is the first prospective effort to evaluate gene expression profiles in clinical practice. Our participation in this protocol, installs us in the first line of worlwide oncological investigationinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.2 20072007-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000200016es10.4067/S0034-98872007000200016
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Breast neoplasms Chemotherapy, adjuvant Gene expression
spellingShingle	Breast neoplasms Chemotherapy, adjuvant Gene expression Corvalán,Alejandro Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
description	In the early stages of breast cancer, surgery and radiotherapy arrest the local and regional disease. However 30% of patients will die as a consequence of tumor dissemination. Parameters with a relative predictive value are used to assess candidates to adjuvant therapy. Genomic analysis methods (cDNA microarray) identified a gene expression profile of greater aggressiveness in breast cancer. This knowledge generated the project "Translating Molecular Knowledge Into Early Breast Cancer Management" of the Breast International Group (BIG). This is a consortium of 32 research groups in which Chile participates through the Chilean Cooperative Oncological Research Group (GOCCHI). The project consists in three protocols. In the first, denomimated MINDACT (Microarray for Node Negative Disease may Avoid Chemotherapy), 8000 women will be evaluated by gene expression profile and clinical pathological criteria to decide adjuvant therapy. Since a group of patients will not receive therapy, solely based on gene expression profile, GOCCHI is preparing a follow up protocol based on the expression of 22 genes. MINDACT is the first prospective effort to evaluate gene expression profiles in clinical practice. Our participation in this protocol, installs us in the first line of worlwide oncological investigation
author	Corvalán,Alejandro
author_facet	Corvalán,Alejandro
author_sort	Corvalán,Alejandro
title	Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
title_short	Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
title_full	Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
title_fullStr	Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
title_full_unstemmed	Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
title_sort	perfiles de expresión génica en decisiones terapéuticas en cáncer de mama
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000200016
work_keys_str_mv	AT corvalanalejandro perfilesdeexpresiongenicaendecisionesterapeuticasencancerdemama
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Perfiles de expresión génica en decisiones terapéuticas en cáncer de mama

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