Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma

Background: The identification of groups at high risk is fundamental to determine preventive strategies for skin cancer. Destructive reactive oxygen species produced by UVA or chemical carcinogens are metabolized by a series of enzymes. Polymorphisms of genes encoding for these enzymes may produce d...

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Autores principales:	Leite,Janaína L, Morari,Elaine C, Granja,Fabiana, Campos,Gabriela M, Guilhen,Ana CT, Ward,Laura S
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Carcinoma, basal cell Glutathione S-transferase Polymorphism, genetic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000300004
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spelling	oai:scielo:S0034-988720070003000042014-01-06Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinomaLeite,Janaína LMorari,Elaine CGranja,FabianaCampos,Gabriela MGuilhen,Ana CTWard,Laura S Carcinoma, basal cell Glutathione S-transferase Polymorphism, genetic Background: The identification of groups at high risk is fundamental to determine preventive strategies for skin cancer. Destructive reactive oxygen species produced by UVA or chemical carcinogens are metabolized by a series of enzymes. Polymorphisms of genes encoding for these enzymes may produce defective proteins with a diminished ability to detoxify a wide range of carcinogens. Aims: To ascertain the influence and potential interactions of several polymorphisms of genes encoding four important antioxidant GST enzymes in the susceptibility to cancer among Brazilians. Material and methods: We compared the genotypes of Glutathione S-Transferase mu, theta, pi and omega (GSTM1, GSTT1, GSTP1 and GSTO2) in a group of 102 patients with skin lesions and 124 controls. Results: Patients with Basal Cell Skin Carcinoma (BCC) presented the combined GSTM1-GSTT1+ genotype more frequently (49.1%) than controls (29.8%) (Fisher test; p =0.04), conferring a 2.273 (Odds Ratio; 95% CI =1.199-4.308) higher risk for BCC. We were not able to find any other association between genotypes or between any genotype and the patients' clinical features. Conclusions: The GST profile may help identify Brazilian individuals at higher risk for BCCinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.3 20072007-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000300004en10.4067/S0034-98872007000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Carcinoma, basal cell Glutathione S-transferase Polymorphism, genetic
spellingShingle	Carcinoma, basal cell Glutathione S-transferase Polymorphism, genetic Leite,Janaína L Morari,Elaine C Granja,Fabiana Campos,Gabriela M Guilhen,Ana CT Ward,Laura S Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
description	Background: The identification of groups at high risk is fundamental to determine preventive strategies for skin cancer. Destructive reactive oxygen species produced by UVA or chemical carcinogens are metabolized by a series of enzymes. Polymorphisms of genes encoding for these enzymes may produce defective proteins with a diminished ability to detoxify a wide range of carcinogens. Aims: To ascertain the influence and potential interactions of several polymorphisms of genes encoding four important antioxidant GST enzymes in the susceptibility to cancer among Brazilians. Material and methods: We compared the genotypes of Glutathione S-Transferase mu, theta, pi and omega (GSTM1, GSTT1, GSTP1 and GSTO2) in a group of 102 patients with skin lesions and 124 controls. Results: Patients with Basal Cell Skin Carcinoma (BCC) presented the combined GSTM1-GSTT1+ genotype more frequently (49.1%) than controls (29.8%) (Fisher test; p =0.04), conferring a 2.273 (Odds Ratio; 95% CI =1.199-4.308) higher risk for BCC. We were not able to find any other association between genotypes or between any genotype and the patients' clinical features. Conclusions: The GST profile may help identify Brazilian individuals at higher risk for BCC
author	Leite,Janaína L Morari,Elaine C Granja,Fabiana Campos,Gabriela M Guilhen,Ana CT Ward,Laura S
author_facet	Leite,Janaína L Morari,Elaine C Granja,Fabiana Campos,Gabriela M Guilhen,Ana CT Ward,Laura S
author_sort	Leite,Janaína L
title	Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
title_short	Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
title_full	Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
title_fullStr	Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
title_full_unstemmed	Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
title_sort	influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000300004
work_keys_str_mv	AT leitejanainal influenceoftheglutathionestransferasegenepolymorphismsonthesusceptibilitytobasalcellskincarcinoma AT morarielainec influenceoftheglutathionestransferasegenepolymorphismsonthesusceptibilitytobasalcellskincarcinoma AT granjafabiana influenceoftheglutathionestransferasegenepolymorphismsonthesusceptibilitytobasalcellskincarcinoma AT camposgabrielam influenceoftheglutathionestransferasegenepolymorphismsonthesusceptibilitytobasalcellskincarcinoma AT guilhenanact influenceoftheglutathionestransferasegenepolymorphismsonthesusceptibilitytobasalcellskincarcinoma AT wardlauras influenceoftheglutathionestransferasegenepolymorphismsonthesusceptibilitytobasalcellskincarcinoma
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Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma

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