Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto

Abstract: Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Mennickent C,Sigrid, Vega H,Mario, Godoy M,Carmen Gloria, León H,M. Doris
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Carbamazepine Epilepsy Saliva
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000300008
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872007000300008
record_format	dspace
spelling	oai:scielo:S0034-988720070003000082014-01-06Relación entre niveles de carbamazepina en saliva y plasma: Estudio pilotoMennickent C,SigridVega H,MarioGodoy M,Carmen GloriaLeón H,M. Doris Carbamazepine Epilepsy Saliva Abstract: Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels. Aim: To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy. Material and Methods: Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months. Results: The mean saliva/plasma ratio was 0.18±0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97±5.40. There was a poor linear correlation (r =0.37) between the concentrations of carbamazepine in both fluids. Conclusions: In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weakinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.3 20072007-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000300008es10.4067/S0034-98872007000300008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Carbamazepine Epilepsy Saliva
spellingShingle	Carbamazepine Epilepsy Saliva Mennickent C,Sigrid Vega H,Mario Godoy M,Carmen Gloria León H,M. Doris Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto
description	Abstract: Carbamazepine is one of the most commonly used anticonvulsants for the treatment of epilepsy and its plasma concentrations must be monitored periodically to obtain a useful and safe clinical effect. There is not a good relationship between the dose of the carbamazepine and their effects in humans, but the effects of this drug have been well correlated with its plasma levels. Aim: To measure the correlation between plasma and saliva levels of carbamazepine in children with epilepsy. Material and Methods: Saliva and plasma levels of carbamazepine were measured by using instrumental planar chromatography in 11 epileptic children aged 8 to 15 years treated with the drug for at least six months. Results: The mean saliva/plasma ratio was 0.18±0.05 and the mean of carbamazepine concentration in saliva, expressed as a percentage of concentrations in plasma, was 17.97±5.40. There was a poor linear correlation (r =0.37) between the concentrations of carbamazepine in both fluids. Conclusions: In this group of epileptic children the correlation between saliva and plasma carbamazepine levels was weak
author	Mennickent C,Sigrid Vega H,Mario Godoy M,Carmen Gloria León H,M. Doris
author_facet	Mennickent C,Sigrid Vega H,Mario Godoy M,Carmen Gloria León H,M. Doris
author_sort	Mennickent C,Sigrid
title	Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto
title_short	Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto
title_full	Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto
title_fullStr	Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto
title_full_unstemmed	Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto
title_sort	relación entre niveles de carbamazepina en saliva y plasma: estudio piloto
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000300008
work_keys_str_mv	AT mennickentcsigrid relacionentrenivelesdecarbamazepinaensalivayplasmaestudiopiloto AT vegahmario relacionentrenivelesdecarbamazepinaensalivayplasmaestudiopiloto AT godoymcarmengloria relacionentrenivelesdecarbamazepinaensalivayplasmaestudiopiloto AT leonhmdoris relacionentrenivelesdecarbamazepinaensalivayplasmaestudiopiloto
_version_	1718436310513876992

Relación entre niveles de carbamazepina en saliva y plasma: Estudio piloto

Ejemplares similares