El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana

Background: It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. Aim: To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. Patients and methods: Cros...

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Autores principales: Zavalza G,Ana Bertha, Graver P,Fernando, Mora M,José Miguel, Centeno L,Mayarf, Anaya P,Roberto
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2007
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000500009
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spelling oai:scielo:S0034-988720070005000092007-07-09El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia tempranaZavalza G,Ana BerthaGraver P,FernandoMora M,José MiguelCenteno L,MayarfAnaya P,Roberto Hyperlipoproteinemias Insulin resistance Postmenopause Background: It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. Aim: To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. Patients and methods: Cross-sectional study of 66 early postmenopausal women aged 45 to 55years. Body mass index (BMI), waist-to hip ratio (WHR), total body adiposity, systolic blood pressure (SBP), diastolic blood pressure (DBF), mean blood pressure (MBP) and pulse pressure (PP) were measured. Total cholesterol, low-density ¡ipoproteins, high-density ¡ipoproteins, triglycerides, glucose and insulin were determined in a fasting blood sample. Insulin sensitivity was calculated using the homeostasis model assessment method (HOMA) and patients were stratified in quartiles according to this parameter. Results: Patients stratified in the different quartiles of insulin sensitivity were comparable in age and postmenopausal period, but had no differences in serum lipid levels. Compared to women in the lower quartile of insulin resistance, women in the upper quartile had higher BMI (23 and 27 kg/m² respectively, p =0.02), SBP (110 and 125 mmHg respectively, p <0.01) and MBP (83 and 93 mmHg respectively, p <0.01). Differences in total body adiposity were observed between the lower, third, and the upper quartile (30%, 35% and 36% respectively, p <0.01). Conclusions: In this group of early postmenopausal women, no association was observed between the level of insulin sensitivity and serum lipid levelsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.5 20072007-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000500009es10.4067/S0034-98872007000500009
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Hyperlipoproteinemias
Insulin resistance
Postmenopause
spellingShingle Hyperlipoproteinemias
Insulin resistance
Postmenopause
Zavalza G,Ana Bertha
Graver P,Fernando
Mora M,José Miguel
Centeno L,Mayarf
Anaya P,Roberto
El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
description Background: It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. Aim: To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. Patients and methods: Cross-sectional study of 66 early postmenopausal women aged 45 to 55years. Body mass index (BMI), waist-to hip ratio (WHR), total body adiposity, systolic blood pressure (SBP), diastolic blood pressure (DBF), mean blood pressure (MBP) and pulse pressure (PP) were measured. Total cholesterol, low-density ¡ipoproteins, high-density ¡ipoproteins, triglycerides, glucose and insulin were determined in a fasting blood sample. Insulin sensitivity was calculated using the homeostasis model assessment method (HOMA) and patients were stratified in quartiles according to this parameter. Results: Patients stratified in the different quartiles of insulin sensitivity were comparable in age and postmenopausal period, but had no differences in serum lipid levels. Compared to women in the lower quartile of insulin resistance, women in the upper quartile had higher BMI (23 and 27 kg/m² respectively, p =0.02), SBP (110 and 125 mmHg respectively, p <0.01) and MBP (83 and 93 mmHg respectively, p <0.01). Differences in total body adiposity were observed between the lower, third, and the upper quartile (30%, 35% and 36% respectively, p <0.01). Conclusions: In this group of early postmenopausal women, no association was observed between the level of insulin sensitivity and serum lipid levels
author Zavalza G,Ana Bertha
Graver P,Fernando
Mora M,José Miguel
Centeno L,Mayarf
Anaya P,Roberto
author_facet Zavalza G,Ana Bertha
Graver P,Fernando
Mora M,José Miguel
Centeno L,Mayarf
Anaya P,Roberto
author_sort Zavalza G,Ana Bertha
title El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_short El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_full El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_fullStr El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_full_unstemmed El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_sort el cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
publisher Sociedad Médica de Santiago
publishDate 2007
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000500009
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