El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana

Background: It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. Aim: To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. Patients and methods: Cros...

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Autores principales:	Zavalza G,Ana Bertha, Graver P,Fernando, Mora M,José Miguel, Centeno L,Mayarf, Anaya P,Roberto
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Hyperlipoproteinemias Insulin resistance Postmenopause
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000500009
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spelling	oai:scielo:S0034-988720070005000092007-07-09El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia tempranaZavalza G,Ana BerthaGraver P,FernandoMora M,José MiguelCenteno L,MayarfAnaya P,Roberto Hyperlipoproteinemias Insulin resistance Postmenopause Background: It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. Aim: To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. Patients and methods: Cross-sectional study of 66 early postmenopausal women aged 45 to 55years. Body mass index (BMI), waist-to hip ratio (WHR), total body adiposity, systolic blood pressure (SBP), diastolic blood pressure (DBF), mean blood pressure (MBP) and pulse pressure (PP) were measured. Total cholesterol, low-density ¡ipoproteins, high-density ¡ipoproteins, triglycerides, glucose and insulin were determined in a fasting blood sample. Insulin sensitivity was calculated using the homeostasis model assessment method (HOMA) and patients were stratified in quartiles according to this parameter. Results: Patients stratified in the different quartiles of insulin sensitivity were comparable in age and postmenopausal period, but had no differences in serum lipid levels. Compared to women in the lower quartile of insulin resistance, women in the upper quartile had higher BMI (23 and 27 kg/m² respectively, p =0.02), SBP (110 and 125 mmHg respectively, p <0.01) and MBP (83 and 93 mmHg respectively, p <0.01). Differences in total body adiposity were observed between the lower, third, and the upper quartile (30%, 35% and 36% respectively, p <0.01). Conclusions: In this group of early postmenopausal women, no association was observed between the level of insulin sensitivity and serum lipid levelsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.5 20072007-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000500009es10.4067/S0034-98872007000500009
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hyperlipoproteinemias Insulin resistance Postmenopause
spellingShingle	Hyperlipoproteinemias Insulin resistance Postmenopause Zavalza G,Ana Bertha Graver P,Fernando Mora M,José Miguel Centeno L,Mayarf Anaya P,Roberto El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
description	Background: It is not clear if changes in serum lipid profile during menopause are related to changes in the distribution of fat or to insulin resistance. Aim: To look for an association between insulin resistance and changes in serum lipid levels in post menopausal women. Patients and methods: Cross-sectional study of 66 early postmenopausal women aged 45 to 55years. Body mass index (BMI), waist-to hip ratio (WHR), total body adiposity, systolic blood pressure (SBP), diastolic blood pressure (DBF), mean blood pressure (MBP) and pulse pressure (PP) were measured. Total cholesterol, low-density ¡ipoproteins, high-density ¡ipoproteins, triglycerides, glucose and insulin were determined in a fasting blood sample. Insulin sensitivity was calculated using the homeostasis model assessment method (HOMA) and patients were stratified in quartiles according to this parameter. Results: Patients stratified in the different quartiles of insulin sensitivity were comparable in age and postmenopausal period, but had no differences in serum lipid levels. Compared to women in the lower quartile of insulin resistance, women in the upper quartile had higher BMI (23 and 27 kg/m² respectively, p =0.02), SBP (110 and 125 mmHg respectively, p <0.01) and MBP (83 and 93 mmHg respectively, p <0.01). Differences in total body adiposity were observed between the lower, third, and the upper quartile (30%, 35% and 36% respectively, p <0.01). Conclusions: In this group of early postmenopausal women, no association was observed between the level of insulin sensitivity and serum lipid levels
author	Zavalza G,Ana Bertha Graver P,Fernando Mora M,José Miguel Centeno L,Mayarf Anaya P,Roberto
author_facet	Zavalza G,Ana Bertha Graver P,Fernando Mora M,José Miguel Centeno L,Mayarf Anaya P,Roberto
author_sort	Zavalza G,Ana Bertha
title	El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_short	El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_full	El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_fullStr	El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_full_unstemmed	El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
title_sort	el cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000500009
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El cambio en la sensibilidad a la insulina no altera el perfil de lípidos en mujeres con posmenopausia temprana

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