Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue

Background: Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases. Aim: To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. Patients and Methods: Between April 2003 and December 200...

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Autores principales:	Rojas,Elsa Marina, Díaz-Quijano,Fredi Alexander, Coronel-Ruiz,Carolina, Martínez-Vega,Ruth Aralf, Rueda,Ernesto, Villar-Centeno,Luis Ángel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Arthralgia Dengue Fever Glutathione peroxidase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000600008
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spelling	oai:scielo:S0034-988720070006000082014-01-06Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengueRojas,Elsa MarinaDíaz-Quijano,Fredi AlexanderCoronel-Ruiz,CarolinaMartínez-Vega,Ruth AralfRueda,ErnestoVillar-Centeno,Luis Ángel Arthralgia Dengue Fever Glutathione peroxidase Background: Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases. Aim: To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. Patients and Methods: Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up. Results: Mean GP values were 1198 U/L (95% confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L. Conclusions: GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengueinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.6 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000600008es10.4067/S0034-98872007000600008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Arthralgia Dengue Fever Glutathione peroxidase
spellingShingle	Arthralgia Dengue Fever Glutathione peroxidase Rojas,Elsa Marina Díaz-Quijano,Fredi Alexander Coronel-Ruiz,Carolina Martínez-Vega,Ruth Aralf Rueda,Ernesto Villar-Centeno,Luis Ángel Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue
description	Background: Glutathione peroxidase (GP) can be used as a marker of oxidative stress in infectious diseases. Aim: To evaluate the association between the levels of glutathione peroxidase (GP) and the manifestations and complications of dengue. Patients and Methods: Between April 2003 and December 2004, 161 patients with dengue were prospectively evaluated. In the first evaluation, within 48 and 96 hours of disease onset, a plasma sample was obtained to measure the GP levels. The association between GP levels, clinical manifestations and complications was evaluated during the follow up. Results: Mean GP values were 1198 U/L (95% confidence interval 1089-1306). Values greater than 1200 U/L were associated with headache, arthralgias and increased heart rate. There was a negative association between GP levels and serum triglycerides. During follow up, patients with GP >1200 U/L had a higher frequency of spontaneous hemorrhages. In a logistic regression analysis arthralgias, fever and increased heart rate, were independently associated with levels >1200 U/L. Conclusions: GP levels was associated to some of the manifestations of dengue. This finding suggests that the intensity of oxidative stress can influence the clinical presentation of dengue
author	Rojas,Elsa Marina Díaz-Quijano,Fredi Alexander Coronel-Ruiz,Carolina Martínez-Vega,Ruth Aralf Rueda,Ernesto Villar-Centeno,Luis Ángel
author_facet	Rojas,Elsa Marina Díaz-Quijano,Fredi Alexander Coronel-Ruiz,Carolina Martínez-Vega,Ruth Aralf Rueda,Ernesto Villar-Centeno,Luis Ángel
author_sort	Rojas,Elsa Marina
title	Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue
title_short	Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue
title_full	Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue
title_fullStr	Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue
title_full_unstemmed	Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue
title_sort	correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000600008
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Correlación entre los niveles de glutatión peroxidasa, un marcador de estrés oxidativo, y la presentación clínica del dengue

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