Blancos terapéuticos potenciales para revertir la cirrosis hepática

Liver fibrosis is the common response to chronic liver injury, ultimately leading to cirrhosis and its complications: portal hypertension, liver failure, hepatic encephalopathy, and hepatocellular carcinoma and others. Efficient and well-tolerated antifibrotic drugs are still lacking, and current tr...

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Autores principales:	García B,Leonel, Gálvez G,Javier, Armendáriz B,Juan
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Fatty liver Fibrosis Liver cirrhosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000600015
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spelling	oai:scielo:S0034-988720070006000152014-01-06Blancos terapéuticos potenciales para revertir la cirrosis hepáticaGarcía B,LeonelGálvez G,JavierArmendáriz B,Juan Fatty liver Fibrosis Liver cirrhosis Liver fibrosis is the common response to chronic liver injury, ultimately leading to cirrhosis and its complications: portal hypertension, liver failure, hepatic encephalopathy, and hepatocellular carcinoma and others. Efficient and well-tolerated antifibrotic drugs are still lacking, and current treatment of hepatic fibrosis is limited to withdrawal of the noxious agent. Efforts over the past decade have mainly focused on fibrogenic cells generating the scarring response, although promising data on inhibition of parenchymal injury or reduction of liver inflammation have also been obtained. A large number of approaches have been validated in culture studies and in animal models, and several clinical trials are underway or anticipated for a growing number of molecules. This review highlight recent advances in the molecular mechanisms of liver fibrosis and discusses mechanistically based strategies that have recently emergedinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.6 20072007-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000600015es10.4067/S0034-98872007000600015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Fatty liver Fibrosis Liver cirrhosis
spellingShingle	Fatty liver Fibrosis Liver cirrhosis García B,Leonel Gálvez G,Javier Armendáriz B,Juan Blancos terapéuticos potenciales para revertir la cirrosis hepática
description	Liver fibrosis is the common response to chronic liver injury, ultimately leading to cirrhosis and its complications: portal hypertension, liver failure, hepatic encephalopathy, and hepatocellular carcinoma and others. Efficient and well-tolerated antifibrotic drugs are still lacking, and current treatment of hepatic fibrosis is limited to withdrawal of the noxious agent. Efforts over the past decade have mainly focused on fibrogenic cells generating the scarring response, although promising data on inhibition of parenchymal injury or reduction of liver inflammation have also been obtained. A large number of approaches have been validated in culture studies and in animal models, and several clinical trials are underway or anticipated for a growing number of molecules. This review highlight recent advances in the molecular mechanisms of liver fibrosis and discusses mechanistically based strategies that have recently emerged
author	García B,Leonel Gálvez G,Javier Armendáriz B,Juan
author_facet	García B,Leonel Gálvez G,Javier Armendáriz B,Juan
author_sort	García B,Leonel
title	Blancos terapéuticos potenciales para revertir la cirrosis hepática
title_short	Blancos terapéuticos potenciales para revertir la cirrosis hepática
title_full	Blancos terapéuticos potenciales para revertir la cirrosis hepática
title_fullStr	Blancos terapéuticos potenciales para revertir la cirrosis hepática
title_full_unstemmed	Blancos terapéuticos potenciales para revertir la cirrosis hepática
title_sort	blancos terapéuticos potenciales para revertir la cirrosis hepática
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000600015
work_keys_str_mv	AT garciableonel blancosterapeuticospotencialespararevertirlacirrosishepatica AT galvezgjavier blancosterapeuticospotencialespararevertirlacirrosishepatica AT armendarizbjuan blancosterapeuticospotencialespararevertirlacirrosishepatica
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Blancos terapéuticos potenciales para revertir la cirrosis hepática

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