Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico

Wegener's granulomatosis is a systemic necrotizing vasculitis that affects medium size and small vessels. Neurological involvement occurs in 22% to 54% of patients, mainly in the form of mononeuritis multiplex. Central nervous system involvement is reported in only 2% to 8% of the cases. We rep...

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Autores principales:	López-Rodríguez,Raimundo, García-González,Jorge, Campos-Franco,Joaquín, Mallo-González,Nieves, Alende-Sixto,María Rosario
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Meningitis aseptic Vasculitis Wegener granulomatosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000700012
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spelling	oai:scielo:S0034-988720070007000122007-09-06Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínicoLópez-Rodríguez,RaimundoGarcía-González,JorgeCampos-Franco,JoaquínMallo-González,NievesAlende-Sixto,María Rosario Meningitis aseptic Vasculitis Wegener granulomatosis Wegener's granulomatosis is a systemic necrotizing vasculitis that affects medium size and small vessels. Neurological involvement occurs in 22% to 54% of patients, mainly in the form of mononeuritis multiplex. Central nervous system involvement is reported in only 2% to 8% of the cases. We report a 42-year-old male who presented with headache, diplopia, third and sixth cranial nerve palsies and ¡eft eye amaurosis associated to mass located in the ¡eft Meckel cavum and diffuse meningeal involvement. A biopsy of the mass disclosed a chronic granulomatous necrotizing inflammation with Langhans giant cells. A chest CAT scan showed three cavitated lung nodules and ANCA antibodies were positive in a titer of 1:80. Treatment with steroid and cyclophosphamide was started and cranial nerve palsies resolved and the number and size of lung nodules decreased. The patient was lost from follow upinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.7 20072007-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000700012es10.4067/S0034-98872007000700012
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Meningitis aseptic Vasculitis Wegener granulomatosis
spellingShingle	Meningitis aseptic Vasculitis Wegener granulomatosis López-Rodríguez,Raimundo García-González,Jorge Campos-Franco,Joaquín Mallo-González,Nieves Alende-Sixto,María Rosario Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico
description	Wegener's granulomatosis is a systemic necrotizing vasculitis that affects medium size and small vessels. Neurological involvement occurs in 22% to 54% of patients, mainly in the form of mononeuritis multiplex. Central nervous system involvement is reported in only 2% to 8% of the cases. We report a 42-year-old male who presented with headache, diplopia, third and sixth cranial nerve palsies and ¡eft eye amaurosis associated to mass located in the ¡eft Meckel cavum and diffuse meningeal involvement. A biopsy of the mass disclosed a chronic granulomatous necrotizing inflammation with Langhans giant cells. A chest CAT scan showed three cavitated lung nodules and ANCA antibodies were positive in a titer of 1:80. Treatment with steroid and cyclophosphamide was started and cranial nerve palsies resolved and the number and size of lung nodules decreased. The patient was lost from follow up
author	López-Rodríguez,Raimundo García-González,Jorge Campos-Franco,Joaquín Mallo-González,Nieves Alende-Sixto,María Rosario
author_facet	López-Rodríguez,Raimundo García-González,Jorge Campos-Franco,Joaquín Mallo-González,Nieves Alende-Sixto,María Rosario
author_sort	López-Rodríguez,Raimundo
title	Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico
title_short	Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico
title_full	Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico
title_fullStr	Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico
title_full_unstemmed	Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico
title_sort	manifestaciones neurológicas de la granulomatosis de wegener: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000700012
work_keys_str_mv	AT lopezrodriguezraimundo manifestacionesneurologicasdelagranulomatosisdewegenercasoclinico AT garciagonzalezjorge manifestacionesneurologicasdelagranulomatosisdewegenercasoclinico AT camposfrancojoaquin manifestacionesneurologicasdelagranulomatosisdewegenercasoclinico AT mallogonzaleznieves manifestacionesneurologicasdelagranulomatosisdewegenercasoclinico AT alendesixtomariarosario manifestacionesneurologicasdelagranulomatosisdewegenercasoclinico
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Manifestaciones neurológicas de la granulomatosis de Wegener: Caso clínico

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