Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos

Background: The main causes of complications of allogenic hematopoietic stem cell transplantation are infections and graft versus host disease. Aim: To assess the predictive value of C reactive protein (CRP) and procalcitonin (PCT) in the diagnosis of invasive bacterial infections in children with f...

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Autores principales:	Schmidt,Nadia, Palma,Julia, King,Alejandra, Santolaya,María Elena
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Bacterial infections C-Reactive protein Hematopoietic stem cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000800004
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spelling	oai:scielo:S0034-988720070008000042007-10-25Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticosSchmidt,NadiaPalma,JuliaKing,AlejandraSantolaya,María Elena Bacterial infections C-Reactive protein Hematopoietic stem cells Background: The main causes of complications of allogenic hematopoietic stem cell transplantation are infections and graft versus host disease. Aim: To assess the predictive value of C reactive protein (CRP) and procalcitonin (PCT) in the diagnosis of invasive bacterial infections in children with febrüe neutropenia after an allogenic hematopoietic stem cell transplantation. Material and methods: Prospective follow up of patients aged 18 years or ¡ess, with febrile neutropenia after an allogenic hematopoietic stem cell transplantation. In all patients, cultures from sterile sites, CRP and PCT determinations were done. CRP levels were also measured prior to transplantation and three times per week for 30 days after the procedure. An independent evaluator, blinded to the results of CRP and PCT, classified children as with or without invasive bacterial infection. Results: Thirty three patients aged 9±5 years (21 males) were studied. Eight had an invasive bacterial infection. Sensitivity, specificity, positive and negative predictive values of a CRP ³90 mg/L for the diagnosis of invasive bacterial infection were 25, 80, 29 and 77%, respectively. The figures for a PCT ³0.7 ng/ml were 43, 78, 38 and 82%, respectively. No differences in repeated CRP values measured during evolution, were observed. Conclusions: A CRP ³90 mg/L or a PCT ³0.7 ng/ml had a high specificity and negative predictive value but low sensitivity for the diagnosis of invasive bacterial infections in recipients of allogenic hematopoietic stem cell transplantation (Rev Méd Chile 2007; 135: 982-89)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.8 20072007-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000800004es10.4067/S0034-98872007000800004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Bacterial infections C-Reactive protein Hematopoietic stem cells
spellingShingle	Bacterial infections C-Reactive protein Hematopoietic stem cells Schmidt,Nadia Palma,Julia King,Alejandra Santolaya,María Elena Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos
description	Background: The main causes of complications of allogenic hematopoietic stem cell transplantation are infections and graft versus host disease. Aim: To assess the predictive value of C reactive protein (CRP) and procalcitonin (PCT) in the diagnosis of invasive bacterial infections in children with febrüe neutropenia after an allogenic hematopoietic stem cell transplantation. Material and methods: Prospective follow up of patients aged 18 years or ¡ess, with febrile neutropenia after an allogenic hematopoietic stem cell transplantation. In all patients, cultures from sterile sites, CRP and PCT determinations were done. CRP levels were also measured prior to transplantation and three times per week for 30 days after the procedure. An independent evaluator, blinded to the results of CRP and PCT, classified children as with or without invasive bacterial infection. Results: Thirty three patients aged 9±5 years (21 males) were studied. Eight had an invasive bacterial infection. Sensitivity, specificity, positive and negative predictive values of a CRP ³90 mg/L for the diagnosis of invasive bacterial infection were 25, 80, 29 and 77%, respectively. The figures for a PCT ³0.7 ng/ml were 43, 78, 38 and 82%, respectively. No differences in repeated CRP values measured during evolution, were observed. Conclusions: A CRP ³90 mg/L or a PCT ³0.7 ng/ml had a high specificity and negative predictive value but low sensitivity for the diagnosis of invasive bacterial infections in recipients of allogenic hematopoietic stem cell transplantation (Rev Méd Chile 2007; 135: 982-89)
author	Schmidt,Nadia Palma,Julia King,Alejandra Santolaya,María Elena
author_facet	Schmidt,Nadia Palma,Julia King,Alejandra Santolaya,María Elena
author_sort	Schmidt,Nadia
title	Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos
title_short	Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos
title_full	Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos
title_fullStr	Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos
title_full_unstemmed	Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos
title_sort	proteína c reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000800004
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Proteína C reactiva y procalcitonina como marcadores de infección bacteriana en niños con neutropenia febril posterior a trasplante alogénico de progenitores hematopoyéticos

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