Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular

Atrial fibrillation is the most common sustained arrhythmia in clinical practice and is associated to thromboembolic complications. Anticoagulation with vitamin K antagonists is clearly useful to reduce the incidence of emboli, but associated with important limitations. Therefore, there is an active...

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Autores principales:	Montagna M,Rodrigo, Asenjo G,Rene, Morris C,Raimundo, Ortiz O,Mario, Cereceda B,Mauricio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Anticoagulants Atrial fibrillation Thromboembolism
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000800014
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spelling	oai:scielo:S0034-988720070008000142007-10-25Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricularMontagna M,RodrigoAsenjo G,ReneMorris C,RaimundoOrtiz O,MarioCereceda B,Mauricio Anticoagulants Atrial fibrillation Thromboembolism Atrial fibrillation is the most common sustained arrhythmia in clinical practice and is associated to thromboembolic complications. Anticoagulation with vitamin K antagonists is clearly useful to reduce the incidence of emboli, but associated with important limitations. Therefore, there is an active search for medications that are more effective and simpler to prescribe and manage. Synthetic pentasaccharides of heparin such as idraparinux for parenteral use, showed promising results. Direct inhibitors of thrombin were also useful for the prevention of thromboembolism. However, they were withdrawn from the market due to potentially fatal adverse reactions. Other area of investigation has been the effectiveness of the combination of antiplatelet agents such as aspirin and clopidrogel. Although this combination is attractive, results of clinical trials must be awaited to have an opinion about its real usefulness. Finally, ¡eft atrial appendage transcatheter occlusion (PLAATO) is an effective and reasonably safe method for patients with contraindications for anticoagulation or those that continue to embolize despite well prescribed anticoagulation. The long term results of this intervention must also be awaited (Rev Méd Chile 2007; 135: 1048-55)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.8 20072007-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000800014es10.4067/S0034-98872007000800014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Anticoagulants Atrial fibrillation Thromboembolism
spellingShingle	Anticoagulants Atrial fibrillation Thromboembolism Montagna M,Rodrigo Asenjo G,Rene Morris C,Raimundo Ortiz O,Mario Cereceda B,Mauricio Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular
description	Atrial fibrillation is the most common sustained arrhythmia in clinical practice and is associated to thromboembolic complications. Anticoagulation with vitamin K antagonists is clearly useful to reduce the incidence of emboli, but associated with important limitations. Therefore, there is an active search for medications that are more effective and simpler to prescribe and manage. Synthetic pentasaccharides of heparin such as idraparinux for parenteral use, showed promising results. Direct inhibitors of thrombin were also useful for the prevention of thromboembolism. However, they were withdrawn from the market due to potentially fatal adverse reactions. Other area of investigation has been the effectiveness of the combination of antiplatelet agents such as aspirin and clopidrogel. Although this combination is attractive, results of clinical trials must be awaited to have an opinion about its real usefulness. Finally, ¡eft atrial appendage transcatheter occlusion (PLAATO) is an effective and reasonably safe method for patients with contraindications for anticoagulation or those that continue to embolize despite well prescribed anticoagulation. The long term results of this intervention must also be awaited (Rev Méd Chile 2007; 135: 1048-55)
author	Montagna M,Rodrigo Asenjo G,Rene Morris C,Raimundo Ortiz O,Mario Cereceda B,Mauricio
author_facet	Montagna M,Rodrigo Asenjo G,Rene Morris C,Raimundo Ortiz O,Mario Cereceda B,Mauricio
author_sort	Montagna M,Rodrigo
title	Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular
title_short	Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular
title_full	Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular
title_fullStr	Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular
title_full_unstemmed	Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular
title_sort	avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000800014
work_keys_str_mv	AT montagnamrodrigo avancesenlaprevenciondeeventostromboembolicosenpacientesconfibrilacionauricular AT asenjogrene avancesenlaprevenciondeeventostromboembolicosenpacientesconfibrilacionauricular AT morriscraimundo avancesenlaprevenciondeeventostromboembolicosenpacientesconfibrilacionauricular AT ortizomario avancesenlaprevenciondeeventostromboembolicosenpacientesconfibrilacionauricular AT cerecedabmauricio avancesenlaprevenciondeeventostromboembolicosenpacientesconfibrilacionauricular
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Avances en la prevención de eventos tromboembólicos en pacientes con fibrilación auricular

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