Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)

Background: Human T lymphotropic virus type I is associated with tropical spastic paraparesis, that is a chronic and progressive disease which damages specially the cortiespinal tracts. The pathogenesis of this degenerative process remains unknown. Aim: To identify histopathological aspects that cou...

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Autores principales: Cartier R,Luis, Vergara R,Carmen, Valenzuela P,María Antonieta
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2007
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000900007
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spelling oai:scielo:S0034-988720070009000072008-05-30Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)Cartier R,LuisVergara R,CarmenValenzuela P,María Antonieta Axonal injury, diffuse Human T-lymphotropic virus Paraparesis, tropical spastic Background: Human T lymphotropic virus type I is associated with tropical spastic paraparesis, that is a chronic and progressive disease which damages specially the cortiespinal tracts. The pathogenesis of this degenerative process remains unknown. Aim: To identify histopathological aspects that could suggest a pathogenic hypothesis we studied immunohistochemical features in spinal cords obtained from patients that died due to progressive spastic paraparesis. Patients and Methods: Five males and five females, who died between 1990 and 2000, with a mean age of 52 years and mean disease duration of 8.6, were studied. All had a complete clinical and virological diagnosis. Samples were obtained from the frontal motor cortex and spinal cord (cervical, dorsal and lumbar segments), were fixed in formol (10%), included in paraffin, and stained with Haematoxylin and Luxol-fast-blue. Immunohistochemical study was made with anti-neurofilament antibodies 1:100 (M0762, DAKO), anti-APP 1:20 (Rabbit Pre Amyloid protein 51-2700 ZYMED), anti-tau 1:100 (A0024DAKO) and anti-ubiquitine 1:50 (NCL UBIQm Novocastra). Results: All cases had demyelinization and axonal loss in the cortico-spinal tracts; distal and segmental demyelinization of Goll tract; axonal thickening, amyloid precursor protein deposits in the white matter; tau protein aggregation in the spinal cord oligodendrocytes; axonal ubiquitination of sensitive and motor tracts, and subcortical white matter. Neurona! injury was absent. Conclusions: The systematic damage of motor and sensitive tracts of the spinal-cord and the absence of neurona! damage, defines a degenerative process limited to axons. This central axonopathie could be caused by a disturbance of axoplasmic transportinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.9 20072007-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000900007es10.4067/S0034-98872007000900007
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Axonal injury, diffuse
Human T-lymphotropic virus
Paraparesis, tropical spastic
spellingShingle Axonal injury, diffuse
Human T-lymphotropic virus
Paraparesis, tropical spastic
Cartier R,Luis
Vergara R,Carmen
Valenzuela P,María Antonieta
Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)
description Background: Human T lymphotropic virus type I is associated with tropical spastic paraparesis, that is a chronic and progressive disease which damages specially the cortiespinal tracts. The pathogenesis of this degenerative process remains unknown. Aim: To identify histopathological aspects that could suggest a pathogenic hypothesis we studied immunohistochemical features in spinal cords obtained from patients that died due to progressive spastic paraparesis. Patients and Methods: Five males and five females, who died between 1990 and 2000, with a mean age of 52 years and mean disease duration of 8.6, were studied. All had a complete clinical and virological diagnosis. Samples were obtained from the frontal motor cortex and spinal cord (cervical, dorsal and lumbar segments), were fixed in formol (10%), included in paraffin, and stained with Haematoxylin and Luxol-fast-blue. Immunohistochemical study was made with anti-neurofilament antibodies 1:100 (M0762, DAKO), anti-APP 1:20 (Rabbit Pre Amyloid protein 51-2700 ZYMED), anti-tau 1:100 (A0024DAKO) and anti-ubiquitine 1:50 (NCL UBIQm Novocastra). Results: All cases had demyelinization and axonal loss in the cortico-spinal tracts; distal and segmental demyelinization of Goll tract; axonal thickening, amyloid precursor protein deposits in the white matter; tau protein aggregation in the spinal cord oligodendrocytes; axonal ubiquitination of sensitive and motor tracts, and subcortical white matter. Neurona! injury was absent. Conclusions: The systematic damage of motor and sensitive tracts of the spinal-cord and the absence of neurona! damage, defines a degenerative process limited to axons. This central axonopathie could be caused by a disturbance of axoplasmic transport
author Cartier R,Luis
Vergara R,Carmen
Valenzuela P,María Antonieta
author_facet Cartier R,Luis
Vergara R,Carmen
Valenzuela P,María Antonieta
author_sort Cartier R,Luis
title Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)
title_short Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)
title_full Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)
title_fullStr Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)
title_full_unstemmed Inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanoTtipol(HTLV-l)
title_sort inmunohistoquímica de los cambios degenerativos del sistema nervioso central en paraparesias espásticas asociadas al virus linfotrópico humanottipol(htlv-l)
publisher Sociedad Médica de Santiago
publishDate 2007
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007000900007
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