Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar

Gastrointestinal stromal tumors (GIST) have mutations of the tyrosine kinase receptor. When they are localized, the treatment of choice is surgical excision, but advanced tumors have a limited response to chemo or radiotherapy. Imatinib (STI571 or Glivec®) is a selective inhibitor or tyrosine kinase...

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Autores principales:	Garrido S,Marcelo, Moneada M,Mónica, Tapia N,Grace, Méndez O,Gonzalo, Galindo A,Héctor, Huete G,Alvaro, Ibáñez A,Luis, González,Sergio, Alvarez Z,Manuel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Antineoplastic agents Imatinib mesylate Protein kinase inhibitors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001000015
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spelling	oai:scielo:S0034-988720070010000152007-12-20Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminarGarrido S,MarceloMoneada M,MónicaTapia N,GraceMéndez O,GonzaloGalindo A,HéctorHuete G,AlvaroIbáñez A,LuisGonzález,SergioAlvarez Z,Manuel Antineoplastic agents Imatinib mesylate Protein kinase inhibitors Gastrointestinal stromal tumors (GIST) have mutations of the tyrosine kinase receptor. When they are localized, the treatment of choice is surgical excision, but advanced tumors have a limited response to chemo or radiotherapy. Imatinib (STI571 or Glivec®) is a selective inhibitor or tyrosine kinase proteins that has been used successfully in the treatment of advanced GIST. We report four patients (two women) with a metastatic GIST that were treated with Imatinib 400 mg day and followed for 40 months. The disease tumor stabilized in three patients and in one it had an initial reduction and progressed at the end of follow up. Therefore Imatinib can be a therapeutic alternative in patients with metastatic GISTinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.10 20072007-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001000015es10.4067/S0034-98872007001000015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antineoplastic agents Imatinib mesylate Protein kinase inhibitors
spellingShingle	Antineoplastic agents Imatinib mesylate Protein kinase inhibitors Garrido S,Marcelo Moneada M,Mónica Tapia N,Grace Méndez O,Gonzalo Galindo A,Héctor Huete G,Alvaro Ibáñez A,Luis González,Sergio Alvarez Z,Manuel Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar
description	Gastrointestinal stromal tumors (GIST) have mutations of the tyrosine kinase receptor. When they are localized, the treatment of choice is surgical excision, but advanced tumors have a limited response to chemo or radiotherapy. Imatinib (STI571 or Glivec®) is a selective inhibitor or tyrosine kinase proteins that has been used successfully in the treatment of advanced GIST. We report four patients (two women) with a metastatic GIST that were treated with Imatinib 400 mg day and followed for 40 months. The disease tumor stabilized in three patients and in one it had an initial reduction and progressed at the end of follow up. Therefore Imatinib can be a therapeutic alternative in patients with metastatic GIST
author	Garrido S,Marcelo Moneada M,Mónica Tapia N,Grace Méndez O,Gonzalo Galindo A,Héctor Huete G,Alvaro Ibáñez A,Luis González,Sergio Alvarez Z,Manuel
author_facet	Garrido S,Marcelo Moneada M,Mónica Tapia N,Grace Méndez O,Gonzalo Galindo A,Héctor Huete G,Alvaro Ibáñez A,Luis González,Sergio Alvarez Z,Manuel
author_sort	Garrido S,Marcelo
title	Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar
title_short	Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar
title_full	Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar
title_fullStr	Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar
title_full_unstemmed	Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar
title_sort	efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: experiencia preliminar
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001000015
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Efecto de un inhibidor tirosina kinasa (imatinib) en pacientes con tumores estromales gastrointestinales metastásicos: Experiencia preliminar

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