Detección de resistencia primaria en pacientes chilenos infectados por VIH

Background: In countries with universal access to antiretroviral therapy a progressive increase in the number of patients that are infected with resistant virus, is observed. Aim To detect the presence of primary resistance to antiretroviral drugs among patients with a recent diagnosis of HIV infect...

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Autores principales:	Acevedo,William, Gallardo,Ana Marfa, Galaz,José, Afani,Alejandro, Cortés,Esteban
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2007
Materias:	Antiretroviral agents Drug resistance multiple, viral HIV
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001100006
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spelling	oai:scielo:S0034-988720070011000062008-02-08Detección de resistencia primaria en pacientes chilenos infectados por VIHAcevedo,WilliamGallardo,Ana MarfaGalaz,JoséAfani,AlejandroCortés,Esteban Antiretroviral agents Drug resistance multiple, viral HIV Background: In countries with universal access to antiretroviral therapy a progressive increase in the number of patients that are infected with resistant virus, is observed. Aim To detect the presence of primary resistance to antiretroviral drugs among patients with a recent diagnosis of HIV infection. Material and methods: Twenty five male patients aged 25 to 45 years, with a diagnosis of a recent HIV infection, done between 2004 and 2005, were studied. Genotypic resistance to antiretroviral drugs was studied using the Genetic Resistance Test TRUGENE® from Bayer. Results: Resistance mutations were detected in 10 patients. All had an university title or had university studies. All lived in northeastern Santiago and had risky sexual behaviors while traveling abroad. Seven mutations were detected in reverse transcriptase. Of these, three were associated to a high resistance level and four, to an intermediate or low resistance, were also detected. Conclusions: A high frequency of genotypic resistance was detected in this group of Chilean patients recently infected with HIV. A higher socioeconomic status and lifestyle could have influenced these resultsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.11 20072007-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001100006es10.4067/S0034-98872007001100006
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Antiretroviral agents Drug resistance multiple, viral HIV
spellingShingle	Antiretroviral agents Drug resistance multiple, viral HIV Acevedo,William Gallardo,Ana Marfa Galaz,José Afani,Alejandro Cortés,Esteban Detección de resistencia primaria en pacientes chilenos infectados por VIH
description	Background: In countries with universal access to antiretroviral therapy a progressive increase in the number of patients that are infected with resistant virus, is observed. Aim To detect the presence of primary resistance to antiretroviral drugs among patients with a recent diagnosis of HIV infection. Material and methods: Twenty five male patients aged 25 to 45 years, with a diagnosis of a recent HIV infection, done between 2004 and 2005, were studied. Genotypic resistance to antiretroviral drugs was studied using the Genetic Resistance Test TRUGENE® from Bayer. Results: Resistance mutations were detected in 10 patients. All had an university title or had university studies. All lived in northeastern Santiago and had risky sexual behaviors while traveling abroad. Seven mutations were detected in reverse transcriptase. Of these, three were associated to a high resistance level and four, to an intermediate or low resistance, were also detected. Conclusions: A high frequency of genotypic resistance was detected in this group of Chilean patients recently infected with HIV. A higher socioeconomic status and lifestyle could have influenced these results
author	Acevedo,William Gallardo,Ana Marfa Galaz,José Afani,Alejandro Cortés,Esteban
author_facet	Acevedo,William Gallardo,Ana Marfa Galaz,José Afani,Alejandro Cortés,Esteban
author_sort	Acevedo,William
title	Detección de resistencia primaria en pacientes chilenos infectados por VIH
title_short	Detección de resistencia primaria en pacientes chilenos infectados por VIH
title_full	Detección de resistencia primaria en pacientes chilenos infectados por VIH
title_fullStr	Detección de resistencia primaria en pacientes chilenos infectados por VIH
title_full_unstemmed	Detección de resistencia primaria en pacientes chilenos infectados por VIH
title_sort	detección de resistencia primaria en pacientes chilenos infectados por vih
publisher	Sociedad Médica de Santiago
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001100006
work_keys_str_mv	AT acevedowilliam deteccionderesistenciaprimariaenpacienteschilenosinfectadosporvih AT gallardoanamarfa deteccionderesistenciaprimariaenpacienteschilenosinfectadosporvih AT galazjose deteccionderesistenciaprimariaenpacienteschilenosinfectadosporvih AT afanialejandro deteccionderesistenciaprimariaenpacienteschilenosinfectadosporvih AT cortesesteban deteccionderesistenciaprimariaenpacienteschilenosinfectadosporvih
_version_	1718436348618080256

Detección de resistencia primaria en pacientes chilenos infectados por VIH

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