Encefalopatía asociada a Valproato
Valproate can be associated to hyperammonemic encephalopathy, characterized by fluctuating sudden-onset alterations of sensorium, focal symptoms and an increase in the frequency of seizures. We report a 78 year-old female using valproate 1,000 mg/ day for 10 months for the treatment to tonic-clonic...
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Sociedad Médica de Santiago
2007
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oai:scielo:S0034-988720070011000112008-02-08Encefalopatía asociada a ValproatoYoung,PabloFinn,Bárbara CÁlvarez,FlorenciaBruetman,Julio ETrimarchi,Hernán Carnitine Encephalopathy Hyperammonemia Valproic acid Valproate can be associated to hyperammonemic encephalopathy, characterized by fluctuating sudden-onset alterations of sensorium, focal symptoms and an increase in the frequency of seizures. We report a 78 year-old female using valproate 1,000 mg/ day for 10 months for the treatment to tonic-clonic seizures. She was admitted on three occasions in the last fourth months for self limited clouding of sensorium. Laboratory, imaging and electroencephalografic studies were non-contributory Blood ammonia levels were 123 fig/dl (normal: 15-50 fig/dl). Due to the possibility of a hyperammonemic encephalopathy secondary to valproate, the drug was discontinued and she was treated with lactulose and intravenous L-carnitine, 1 g/day The patient showed a complete recovery within 48 hours. This drug-associated encephalopathy is a reversible but potentially fatal cause, probably underdiagnosed, that requires a high index of suspicioninfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.11 20072007-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001100011es10.4067/S0034-98872007001100011 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Carnitine Encephalopathy Hyperammonemia Valproic acid |
| spellingShingle |
Carnitine Encephalopathy Hyperammonemia Valproic acid Young,Pablo Finn,Bárbara C Álvarez,Florencia Bruetman,Julio E Trimarchi,Hernán Encefalopatía asociada a Valproato |
| description |
Valproate can be associated to hyperammonemic encephalopathy, characterized by fluctuating sudden-onset alterations of sensorium, focal symptoms and an increase in the frequency of seizures. We report a 78 year-old female using valproate 1,000 mg/ day for 10 months for the treatment to tonic-clonic seizures. She was admitted on three occasions in the last fourth months for self limited clouding of sensorium. Laboratory, imaging and electroencephalografic studies were non-contributory Blood ammonia levels were 123 fig/dl (normal: 15-50 fig/dl). Due to the possibility of a hyperammonemic encephalopathy secondary to valproate, the drug was discontinued and she was treated with lactulose and intravenous L-carnitine, 1 g/day The patient showed a complete recovery within 48 hours. This drug-associated encephalopathy is a reversible but potentially fatal cause, probably underdiagnosed, that requires a high index of suspicion |
| author |
Young,Pablo Finn,Bárbara C Álvarez,Florencia Bruetman,Julio E Trimarchi,Hernán |
| author_facet |
Young,Pablo Finn,Bárbara C Álvarez,Florencia Bruetman,Julio E Trimarchi,Hernán |
| author_sort |
Young,Pablo |
| title |
Encefalopatía asociada a Valproato |
| title_short |
Encefalopatía asociada a Valproato |
| title_full |
Encefalopatía asociada a Valproato |
| title_fullStr |
Encefalopatía asociada a Valproato |
| title_full_unstemmed |
Encefalopatía asociada a Valproato |
| title_sort |
encefalopatía asociada a valproato |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2007 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001100011 |
| work_keys_str_mv |
AT youngpablo encefalopatiaasociadaavalproato AT finnbarbarac encefalopatiaasociadaavalproato AT alvarezflorencia encefalopatiaasociadaavalproato AT bruetmanjulioe encefalopatiaasociadaavalproato AT trimarchihernan encefalopatiaasociadaavalproato |
| _version_ |
1718436349612130304 |