Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena
Background: Gastric cancer has a direct relation with chronic atrophic gastritis (AG) and intestinal metaplasia (IM), considered as preneoplastic lesions. Determination of serum pepsinogen llevéis (PGI) and pepsinogen I / pepsinogen II ratio (PGI/PGII) can detect this conditions; achieving 70-90% of...
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Sociedad Médica de Santiago
2007
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oai:scielo:S0034-988720070012000032014-01-06Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilenaFernández F,José Ignaciode Aretxabala U,XabierSantander D,RicardoSabah T,SamuelMaira S,JorgeNavarro R,AlexPlanzer D,MarcelaGómez L,FernandoEtchart,MiguelGallegos,IvánTorrens,XimenaFasce P,GerardoReydet,Ivette Gastritis, atrophic Pepsinogens Stomach neoplasms Background: Gastric cancer has a direct relation with chronic atrophic gastritis (AG) and intestinal metaplasia (IM), considered as preneoplastic lesions. Determination of serum pepsinogen llevéis (PGI) and pepsinogen I / pepsinogen II ratio (PGI/PGII) can detect this conditions; achieving 70-90% of gastric cancer detection in early stages. Aim: To determine the cut-off values for serum PGI and PGI/PGII in Chilean subjects, for the detection of gastric preneoplastic lesions, establishing their sensitivity, specificity, positive (PPV) and negative (NPV) predictive values. Patients and Methods: Prospective study of patients subjected to upper gastrointestinal endoscopy and determination of serum pepsinogen levels. The presence and severity of preneoplastic lesions were compared with serum levels of PGI and PGI/PGII. Results: A total of 56 men and 44 women were studied, with a mean age of 43 (14-77) years. There was a significant association (p <0.001) of PGI and PGI/PGII with AG and IM. We obtained a cut-off value of 2.3 for PGI/PGII (sensitivity =70%>, specificity =92%>, PPV =60%>, NPV =95%) and 36 ng/ml for PGI (sensitivity =62%o specificity =64%o, PPV =20%o, NPV =91%), for detection of moderate to severe AG. No patient with normal mucosa had a PGI <20 ng/ml. The combined criteria of PGI/II ≤ 2.3 and/or PGI ≤ 20 ng/ml, obtained a sensitivity of 85%o, specificity of 92%>, PPV of 65%o, and NPV of 97%o. Conclusions: We confirmed a strict relation ofPGIand PGI/PGIIwith the presence of preneoplastic gastric lesions in Chilean patientsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.135 n.12 20072007-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001200003es10.4067/S0034-98872007001200003 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
Spanish / Castilian |
| topic |
Gastritis, atrophic Pepsinogens Stomach neoplasms |
| spellingShingle |
Gastritis, atrophic Pepsinogens Stomach neoplasms Fernández F,José Ignacio de Aretxabala U,Xabier Santander D,Ricardo Sabah T,Samuel Maira S,Jorge Navarro R,Alex Planzer D,Marcela Gómez L,Fernando Etchart,Miguel Gallegos,Iván Torrens,Ximena Fasce P,Gerardo Reydet,Ivette Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena |
| description |
Background: Gastric cancer has a direct relation with chronic atrophic gastritis (AG) and intestinal metaplasia (IM), considered as preneoplastic lesions. Determination of serum pepsinogen llevéis (PGI) and pepsinogen I / pepsinogen II ratio (PGI/PGII) can detect this conditions; achieving 70-90% of gastric cancer detection in early stages. Aim: To determine the cut-off values for serum PGI and PGI/PGII in Chilean subjects, for the detection of gastric preneoplastic lesions, establishing their sensitivity, specificity, positive (PPV) and negative (NPV) predictive values. Patients and Methods: Prospective study of patients subjected to upper gastrointestinal endoscopy and determination of serum pepsinogen levels. The presence and severity of preneoplastic lesions were compared with serum levels of PGI and PGI/PGII. Results: A total of 56 men and 44 women were studied, with a mean age of 43 (14-77) years. There was a significant association (p <0.001) of PGI and PGI/PGII with AG and IM. We obtained a cut-off value of 2.3 for PGI/PGII (sensitivity =70%>, specificity =92%>, PPV =60%>, NPV =95%) and 36 ng/ml for PGI (sensitivity =62%o specificity =64%o, PPV =20%o, NPV =91%), for detection of moderate to severe AG. No patient with normal mucosa had a PGI <20 ng/ml. The combined criteria of PGI/II ≤ 2.3 and/or PGI ≤ 20 ng/ml, obtained a sensitivity of 85%o, specificity of 92%>, PPV of 65%o, and NPV of 97%o. Conclusions: We confirmed a strict relation ofPGIand PGI/PGIIwith the presence of preneoplastic gastric lesions in Chilean patients |
| author |
Fernández F,José Ignacio de Aretxabala U,Xabier Santander D,Ricardo Sabah T,Samuel Maira S,Jorge Navarro R,Alex Planzer D,Marcela Gómez L,Fernando Etchart,Miguel Gallegos,Iván Torrens,Ximena Fasce P,Gerardo Reydet,Ivette |
| author_facet |
Fernández F,José Ignacio de Aretxabala U,Xabier Santander D,Ricardo Sabah T,Samuel Maira S,Jorge Navarro R,Alex Planzer D,Marcela Gómez L,Fernando Etchart,Miguel Gallegos,Iván Torrens,Ximena Fasce P,Gerardo Reydet,Ivette |
| author_sort |
Fernández F,José Ignacio |
| title |
Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena |
| title_short |
Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena |
| title_full |
Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena |
| title_fullStr |
Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena |
| title_full_unstemmed |
Detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena |
| title_sort |
detección de lesiones preneoplásicas gástricas mediante niveles séricos de pepsinógeno en población chilena |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2007 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872007001200003 |
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