Acidosis láctica severa asociada a infusión de propofol: Caso clínico

Propofol infusion syndrome (PRIS) is a rare but potentially lethal complications. This disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance...

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Autores principales:	Romero P,Carlos, Morales R,Mónica, Donaire R,Luisa, Llanos V,Osvaldo, Cornejo R,Rodrigo, Gálvez A,Ricardo, Castro O,José
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Acidosis, lactic Propofol Rhabdomyolysis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000100011
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spelling	oai:scielo:S0034-988720080001000112008-04-30Acidosis láctica severa asociada a infusión de propofol: Caso clínicoRomero P,CarlosMorales R,MónicaDonaire R,LuisaLlanos V,OsvaldoCornejo R,RodrigoGálvez A,RicardoCastro O,José Acidosis, lactic Propofol Rhabdomyolysis Propofol infusion syndrome (PRIS) is a rare but potentially lethal complications. This disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance in mitochondrial long chain fatty acid oxidation. We report a 43 year-old woman who underwent brain surgery due to a vascular malformation. In the immediate postoperative period, she had an unexplained and severe lactic acidosis. During anaesthesia, she received a propofol infusion of 7 mg/kg/h that continued in the UCI at a rate of 3.5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient (Rev Méd Chile 2008; 136: 88-92)info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.1 20082008-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000100011es10.4067/S0034-98872008000100011
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acidosis, lactic Propofol Rhabdomyolysis
spellingShingle	Acidosis, lactic Propofol Rhabdomyolysis Romero P,Carlos Morales R,Mónica Donaire R,Luisa Llanos V,Osvaldo Cornejo R,Rodrigo Gálvez A,Ricardo Castro O,José Acidosis láctica severa asociada a infusión de propofol: Caso clínico
description	Propofol infusion syndrome (PRIS) is a rare but potentially lethal complications. This disorder is triggered under unknown circumstances by a propofol infusion of more than 5 mg/kg/h for more than 48 h. PRIS is characterized by a multiorgan failure and rhabdomyolysis and is induced by a disturbance in mitochondrial long chain fatty acid oxidation. We report a 43 year-old woman who underwent brain surgery due to a vascular malformation. In the immediate postoperative period, she had an unexplained and severe lactic acidosis. During anaesthesia, she received a propofol infusion of 7 mg/kg/h that continued in the UCI at a rate of 3.5 mg/kg/h, for 8 hours more. The suspicion of PRIS motivated immediate discontinuation of propofol with rapid correction of lactic acidosis and full recovery of the patient (Rev Méd Chile 2008; 136: 88-92)
author	Romero P,Carlos Morales R,Mónica Donaire R,Luisa Llanos V,Osvaldo Cornejo R,Rodrigo Gálvez A,Ricardo Castro O,José
author_facet	Romero P,Carlos Morales R,Mónica Donaire R,Luisa Llanos V,Osvaldo Cornejo R,Rodrigo Gálvez A,Ricardo Castro O,José
author_sort	Romero P,Carlos
title	Acidosis láctica severa asociada a infusión de propofol: Caso clínico
title_short	Acidosis láctica severa asociada a infusión de propofol: Caso clínico
title_full	Acidosis láctica severa asociada a infusión de propofol: Caso clínico
title_fullStr	Acidosis láctica severa asociada a infusión de propofol: Caso clínico
title_full_unstemmed	Acidosis láctica severa asociada a infusión de propofol: Caso clínico
title_sort	acidosis láctica severa asociada a infusión de propofol: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000100011
work_keys_str_mv	AT romeropcarlos acidosislacticaseveraasociadaainfusiondepropofolcasoclinico AT moralesrmonica acidosislacticaseveraasociadaainfusiondepropofolcasoclinico AT donairerluisa acidosislacticaseveraasociadaainfusiondepropofolcasoclinico AT llanosvosvaldo acidosislacticaseveraasociadaainfusiondepropofolcasoclinico AT cornejorrodrigo acidosislacticaseveraasociadaainfusiondepropofolcasoclinico AT galvezaricardo acidosislacticaseveraasociadaainfusiondepropofolcasoclinico AT castroojose acidosislacticaseveraasociadaainfusiondepropofolcasoclinico
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Acidosis láctica severa asociada a infusión de propofol: Caso clínico

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