Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico

Background: Ample use of serological markers of high sensitivity and specificity led to relevant changes in the epidemiology of celiac disease. The impact of these changes in our country is poorly known. Aim: To assess the diagnostic procedures, clinical presentations and follow up of celiac disease...

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Autores principales:	Canales R,Paulina, Araya Q,Magdalena, Alliende G,Francisco, Hunter M,Bessie, Alarcón O,Teresa, Chávez S,Eduardo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Celiac disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000300003
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spelling	oai:scielo:S0034-988720080003000032008-06-03Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntricoCanales R,PaulinaAraya Q,MagdalenaAlliende G,FranciscoHunter M,BessieAlarcón O,TeresaChávez S,Eduardo Celiac disease Background: Ample use of serological markers of high sensitivity and specificity led to relevant changes in the epidemiology of celiac disease. The impact of these changes in our country is poorly known. Aim: To assess the diagnostic procedures, clinical presentations and follow up of celiac disease as conducted in current pediatric practice. Material and methods: A multicentric retrospective study of patients diagnosed between 2000 and 2005 in five pediatric hospitals in Santiago, Chile. Data was obtained from clinical records, recorded in electronic spreadsheets and analyzed by descriptive statistics. Results: Seventy four of 83 identified patients fulfilled the inclusion criteria and were analyzed. Mean time to reach the diagnosis was 2.1 years. Cases younger than 10 years presented digestive manifestations such as chronic diarrhea and abdominal distension. Twenty one percent of older patients had atypical presentations (mainly short stature, refractory anaemia). Ten percent of cases were screened because a first degree relative had celiac disease. All patients had significant duodenal/jejunal lesion. IgA-antiendomysial antibodies (n =65) and IgA-antigliadin antibodies (n =23) were the most commonly used screening tests used but often, they were not available for follow up. A second biopsy was planned in all patients but only 26 had it due to repeated dietary transgressions, often due to unnoticed consumption of gluten in poorly labeled products. Conclusions: Digestive manifestations were the main presentation form for celiac disease among patients under 10 years of age. Atypical symptoms become relevant in patients older than 10 years. Antiendomysial and antitransglutaminase antibody measurement should be incorporated for routine screening and follow up of celiac disease in public hospitals. To improve food labeling about their gluten content is neededinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.3 20082008-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000300003es10.4067/S0034-98872008000300003
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Celiac disease
spellingShingle	Celiac disease Canales R,Paulina Araya Q,Magdalena Alliende G,Francisco Hunter M,Bessie Alarcón O,Teresa Chávez S,Eduardo Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico
description	Background: Ample use of serological markers of high sensitivity and specificity led to relevant changes in the epidemiology of celiac disease. The impact of these changes in our country is poorly known. Aim: To assess the diagnostic procedures, clinical presentations and follow up of celiac disease as conducted in current pediatric practice. Material and methods: A multicentric retrospective study of patients diagnosed between 2000 and 2005 in five pediatric hospitals in Santiago, Chile. Data was obtained from clinical records, recorded in electronic spreadsheets and analyzed by descriptive statistics. Results: Seventy four of 83 identified patients fulfilled the inclusion criteria and were analyzed. Mean time to reach the diagnosis was 2.1 years. Cases younger than 10 years presented digestive manifestations such as chronic diarrhea and abdominal distension. Twenty one percent of older patients had atypical presentations (mainly short stature, refractory anaemia). Ten percent of cases were screened because a first degree relative had celiac disease. All patients had significant duodenal/jejunal lesion. IgA-antiendomysial antibodies (n =65) and IgA-antigliadin antibodies (n =23) were the most commonly used screening tests used but often, they were not available for follow up. A second biopsy was planned in all patients but only 26 had it due to repeated dietary transgressions, often due to unnoticed consumption of gluten in poorly labeled products. Conclusions: Digestive manifestations were the main presentation form for celiac disease among patients under 10 years of age. Atypical symptoms become relevant in patients older than 10 years. Antiendomysial and antitransglutaminase antibody measurement should be incorporated for routine screening and follow up of celiac disease in public hospitals. To improve food labeling about their gluten content is needed
author	Canales R,Paulina Araya Q,Magdalena Alliende G,Francisco Hunter M,Bessie Alarcón O,Teresa Chávez S,Eduardo
author_facet	Canales R,Paulina Araya Q,Magdalena Alliende G,Francisco Hunter M,Bessie Alarcón O,Teresa Chávez S,Eduardo
author_sort	Canales R,Paulina
title	Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico
title_short	Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico
title_full	Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico
title_fullStr	Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico
title_full_unstemmed	Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico
title_sort	estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: estudio multicéntrico
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000300003
work_keys_str_mv	AT canalesrpaulina estadoactualdeldiagnosticoypresentacionesclinicasdeenfermedadceliacaestudiomulticentrico AT arayaqmagdalena estadoactualdeldiagnosticoypresentacionesclinicasdeenfermedadceliacaestudiomulticentrico AT alliendegfrancisco estadoactualdeldiagnosticoypresentacionesclinicasdeenfermedadceliacaestudiomulticentrico AT huntermbessie estadoactualdeldiagnosticoypresentacionesclinicasdeenfermedadceliacaestudiomulticentrico AT alarconoteresa estadoactualdeldiagnosticoypresentacionesclinicasdeenfermedadceliacaestudiomulticentrico AT chavezseduardo estadoactualdeldiagnosticoypresentacionesclinicasdeenfermedadceliacaestudiomulticentrico
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Estado actual del diagnóstico y presentaciones clínicas de enfermedad celíaca: Estudio multicéntrico

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