Alternativas terapéuticas actuales de las metástasis hepáticas

The liver is a common site of hematogenous metastasis, especially from gastrointestinal malignancies. Liver metastasis are generally classified as stage IV disease. Previously treatment in such patients was met with great skeptiscism. However, advances in surgical and medical therapies during the la...

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Autores principales:	Martínez C,Jorge, Jarufe C,Nicolás, González D,Robinson, Álvarez Z,Manuel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Hepatectomy Liver neoplasms Neoplasm metastasis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000300015
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spelling	oai:scielo:S0034-988720080003000152008-06-03Alternativas terapéuticas actuales de las metástasis hepáticasMartínez C,JorgeJarufe C,NicolásGonzález D,RobinsonÁlvarez Z,Manuel Hepatectomy Liver neoplasms Neoplasm metastasis The liver is a common site of hematogenous metastasis, especially from gastrointestinal malignancies. Liver metastasis are generally classified as stage IV disease. Previously treatment in such patients was met with great skeptiscism. However, advances in surgical and medical therapies during the last two decades have provided effective therapeutic options for selected patients. Since major hepatic resections are now performed with acceptable morbidity and a mortality rate <3%, colorectal cancer metastasis to the liver are associated with 5-year survival rates of 30% or more. Meanwhile, a variety of new therapies have been developed, including hepatic artery infusion of chemotherapy; alcoholic, crio and radiofrequency ablation and novel strategies of systemic chemotherapy with the development of molecular targeted new products. These new therapeutic armamentarium have been used mostly in liver metastasis from colorectal cancer patients. However, liver metastasis of neuroendocrine tumors and selected cases of non colorectal cancer liver metastasis are benefited from the same strategies. This report summarizes the different therapeutic tools, their advantages and results mainly on colorectal cancer liver metastasis. These results are expected to improve even further with multimodality approachesinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.3 20082008-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000300015es10.4067/S0034-98872008000300015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Hepatectomy Liver neoplasms Neoplasm metastasis
spellingShingle	Hepatectomy Liver neoplasms Neoplasm metastasis Martínez C,Jorge Jarufe C,Nicolás González D,Robinson Álvarez Z,Manuel Alternativas terapéuticas actuales de las metástasis hepáticas
description	The liver is a common site of hematogenous metastasis, especially from gastrointestinal malignancies. Liver metastasis are generally classified as stage IV disease. Previously treatment in such patients was met with great skeptiscism. However, advances in surgical and medical therapies during the last two decades have provided effective therapeutic options for selected patients. Since major hepatic resections are now performed with acceptable morbidity and a mortality rate <3%, colorectal cancer metastasis to the liver are associated with 5-year survival rates of 30% or more. Meanwhile, a variety of new therapies have been developed, including hepatic artery infusion of chemotherapy; alcoholic, crio and radiofrequency ablation and novel strategies of systemic chemotherapy with the development of molecular targeted new products. These new therapeutic armamentarium have been used mostly in liver metastasis from colorectal cancer patients. However, liver metastasis of neuroendocrine tumors and selected cases of non colorectal cancer liver metastasis are benefited from the same strategies. This report summarizes the different therapeutic tools, their advantages and results mainly on colorectal cancer liver metastasis. These results are expected to improve even further with multimodality approaches
author	Martínez C,Jorge Jarufe C,Nicolás González D,Robinson Álvarez Z,Manuel
author_facet	Martínez C,Jorge Jarufe C,Nicolás González D,Robinson Álvarez Z,Manuel
author_sort	Martínez C,Jorge
title	Alternativas terapéuticas actuales de las metástasis hepáticas
title_short	Alternativas terapéuticas actuales de las metástasis hepáticas
title_full	Alternativas terapéuticas actuales de las metástasis hepáticas
title_fullStr	Alternativas terapéuticas actuales de las metástasis hepáticas
title_full_unstemmed	Alternativas terapéuticas actuales de las metástasis hepáticas
title_sort	alternativas terapéuticas actuales de las metástasis hepáticas
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000300015
work_keys_str_mv	AT martinezcjorge alternativasterapeuticasactualesdelasmetastasishepaticas AT jarufecnicolas alternativasterapeuticasactualesdelasmetastasishepaticas AT gonzalezdrobinson alternativasterapeuticasactualesdelasmetastasishepaticas AT alvarezzmanuel alternativasterapeuticasactualesdelasmetastasishepaticas
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Alternativas terapéuticas actuales de las metástasis hepáticas

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