Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile

Acute myocardial infarction (AMI) is the first cause of death in Chile. Aim To assess the magnitude of risk of individuals and population associated with AMI risk factors. Material and methods: Case control study with incident cases and 2 controls paired by age and gender. History of diabetes, hyper...

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Autores principales:	Lanas,Fernando, Potthoff,Sergio, Mercadal,Enrique, Santibáñez,Claudio, Lanas,Alejandra, Standen,Dina
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Coronary artery disease Dyslipidemias Myocardial infarction
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000500002
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spelling	oai:scielo:S0034-988720080005000022008-07-30Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART ChileLanas,FernandoPotthoff,SergioMercadal,EnriqueSantibáñez,ClaudioLanas,AlejandraStanden,Dina Coronary artery disease Dyslipidemias Myocardial infarction Acute myocardial infarction (AMI) is the first cause of death in Chile. Aim To assess the magnitude of risk of individuals and population associated with AMI risk factors. Material and methods: Case control study with incident cases and 2 controls paired by age and gender. History of diabetes, hypertension, smoking, stress, depression, diet, weight, height, hip and waist circumference, apolipoprotein (Apo) Al and B were determined. Odds ratio (OR) and population attributable risk (PAR) were calculated with 95% confidence interval. Results: Three hundred thirty two cases and 672 controls were included. Mean age was 61.6±12 years and 22% were women. The higher individual risk was associated with smoking: OR 3.1 (2.3-4.2), hypertension: 2.9 (2.1-3.9), permanent stress: 2.2 (1,3-2,8), increased apoB/ApoAl ratio: 2.1 (1.4-3.0) and diabetes: 2.0 (1.4-2.9). A protective effect of daily consumption of vegetables and/or fruits with and OR of 0.54 (0.4-0.8), was observed. The highest PAR was due to smoking: 42% (33.2-51.4), increased ApoB/ApoAl ratio: 35.2 (19.0-55.8) and hypertension: 32% (24.5-40.8). These three factors explained 71.3% of the AMI risk in Chile. A moderate effect on PAR was observed for abdominal obesity: 16.6% (2.4-61.2), permanent stress: 12.0% (2.3-44.1) and diabetes: 10.8% (6.1-18.3). Conclusions: Known risk factors ¡ike dyslipidemia, smoking and hypertension explain most of the AMI cases in Chile. The control of these risk factors should have a major effect on morbidity and mortality due to coronary artery disease in our countryinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.5 20082008-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000500002es10.4067/S0034-98872008000500002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Coronary artery disease Dyslipidemias Myocardial infarction
spellingShingle	Coronary artery disease Dyslipidemias Myocardial infarction Lanas,Fernando Potthoff,Sergio Mercadal,Enrique Santibáñez,Claudio Lanas,Alejandra Standen,Dina Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile
description	Acute myocardial infarction (AMI) is the first cause of death in Chile. Aim To assess the magnitude of risk of individuals and population associated with AMI risk factors. Material and methods: Case control study with incident cases and 2 controls paired by age and gender. History of diabetes, hypertension, smoking, stress, depression, diet, weight, height, hip and waist circumference, apolipoprotein (Apo) Al and B were determined. Odds ratio (OR) and population attributable risk (PAR) were calculated with 95% confidence interval. Results: Three hundred thirty two cases and 672 controls were included. Mean age was 61.6±12 years and 22% were women. The higher individual risk was associated with smoking: OR 3.1 (2.3-4.2), hypertension: 2.9 (2.1-3.9), permanent stress: 2.2 (1,3-2,8), increased apoB/ApoAl ratio: 2.1 (1.4-3.0) and diabetes: 2.0 (1.4-2.9). A protective effect of daily consumption of vegetables and/or fruits with and OR of 0.54 (0.4-0.8), was observed. The highest PAR was due to smoking: 42% (33.2-51.4), increased ApoB/ApoAl ratio: 35.2 (19.0-55.8) and hypertension: 32% (24.5-40.8). These three factors explained 71.3% of the AMI risk in Chile. A moderate effect on PAR was observed for abdominal obesity: 16.6% (2.4-61.2), permanent stress: 12.0% (2.3-44.1) and diabetes: 10.8% (6.1-18.3). Conclusions: Known risk factors ¡ike dyslipidemia, smoking and hypertension explain most of the AMI cases in Chile. The control of these risk factors should have a major effect on morbidity and mortality due to coronary artery disease in our country
author	Lanas,Fernando Potthoff,Sergio Mercadal,Enrique Santibáñez,Claudio Lanas,Alejandra Standen,Dina
author_facet	Lanas,Fernando Potthoff,Sergio Mercadal,Enrique Santibáñez,Claudio Lanas,Alejandra Standen,Dina
author_sort	Lanas,Fernando
title	Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile
title_short	Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile
title_full	Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile
title_fullStr	Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile
title_full_unstemmed	Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile
title_sort	riesgo individual y poblacional en infarto agudo del miocardio: estudio interheart chile
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000500002
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Riesgo individual y poblacional en infarto agudo del miocardio: Estudio INTERHEART Chile

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