Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad

Tuberculosis (TB) in Chile is reaching the elimination phase; however, in HIV positive individuals the incidence ofTB in still very high. Aim To describe the association between TB and HIV in different geographical regions in Chile, and to determine the association between TB and HIV/AIDS mortality....

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Autores principales:	Villarroel,Luis, Rabagliati,Ricardo, Balcells,M. Elvira, Karzulovic,Lorena, Pérez,Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	HIV Prevalence Tuberculosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000500005
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spelling	oai:scielo:S0034-988720080005000052008-07-30Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidadVillarroel,LuisRabagliati,RicardoBalcells,M. ElviraKarzulovic,LorenaPérez,Carlos HIV Prevalence Tuberculosis Tuberculosis (TB) in Chile is reaching the elimination phase; however, in HIV positive individuals the incidence ofTB in still very high. Aim To describe the association between TB and HIV in different geographical regions in Chile, and to determine the association between TB and HIV/AIDS mortality. Patients and methods: A retrospective study that included individuals from the main HIV clinics from four regions with different TB prevalence in the general population (per 100,000): Arica (>30), Concepcion/Arauco (25-29), Valparaiso/San Antonio (20-24) and Metropolitana Sur-Oriente (SSMSO) (<20), attended between January 1998 and September 2004. Results: Nine hundred and twelve HIV positive individuals were included. Gobal prevalence ofTB was 6.2% [95% confidence intervals (Cl) 5.2-7.2%]. TB was more common in older subjects (p =0.039) and those with lower CD4 counts (p <0.001) and higher HIV viral load (p =0.033). In 66% of cases, the disease had a pulmonary localization. TB was the recorded cause of death in 7.4% of subjects. Only 29% of patients had a tuberculin skin test performed at the moment of HIV diagnosis. The prevalence of TB in HIV positive patients, followed the trend of TB prevalence in the general population: Concepcion/Arauco (11.9%), Valparaiso/San Antonio (7.1%) and SSMSO (3.9%). However HIV positive subjects from Arica showed an unexpectedly low TB prevalence (5.5%). Conclusions: TB in HIV/AIDS patients included in this study is over 300 times more prevalent than in the general population. TB prevalence in HIV positive subjects follows regional TB prevalence, excepting Arica. Effectiveness and feasibility of latent TB diagnostic strategies and treatment in HIV positive individuals should be reviewedinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.5 20082008-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000500005es10.4067/S0034-98872008000500005
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	HIV Prevalence Tuberculosis
spellingShingle	HIV Prevalence Tuberculosis Villarroel,Luis Rabagliati,Ricardo Balcells,M. Elvira Karzulovic,Lorena Pérez,Carlos Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad
description	Tuberculosis (TB) in Chile is reaching the elimination phase; however, in HIV positive individuals the incidence ofTB in still very high. Aim To describe the association between TB and HIV in different geographical regions in Chile, and to determine the association between TB and HIV/AIDS mortality. Patients and methods: A retrospective study that included individuals from the main HIV clinics from four regions with different TB prevalence in the general population (per 100,000): Arica (>30), Concepcion/Arauco (25-29), Valparaiso/San Antonio (20-24) and Metropolitana Sur-Oriente (SSMSO) (<20), attended between January 1998 and September 2004. Results: Nine hundred and twelve HIV positive individuals were included. Gobal prevalence ofTB was 6.2% [95% confidence intervals (Cl) 5.2-7.2%]. TB was more common in older subjects (p =0.039) and those with lower CD4 counts (p <0.001) and higher HIV viral load (p =0.033). In 66% of cases, the disease had a pulmonary localization. TB was the recorded cause of death in 7.4% of subjects. Only 29% of patients had a tuberculin skin test performed at the moment of HIV diagnosis. The prevalence of TB in HIV positive patients, followed the trend of TB prevalence in the general population: Concepcion/Arauco (11.9%), Valparaiso/San Antonio (7.1%) and SSMSO (3.9%). However HIV positive subjects from Arica showed an unexpectedly low TB prevalence (5.5%). Conclusions: TB in HIV/AIDS patients included in this study is over 300 times more prevalent than in the general population. TB prevalence in HIV positive subjects follows regional TB prevalence, excepting Arica. Effectiveness and feasibility of latent TB diagnostic strategies and treatment in HIV positive individuals should be reviewed
author	Villarroel,Luis Rabagliati,Ricardo Balcells,M. Elvira Karzulovic,Lorena Pérez,Carlos
author_facet	Villarroel,Luis Rabagliati,Ricardo Balcells,M. Elvira Karzulovic,Lorena Pérez,Carlos
author_sort	Villarroel,Luis
title	Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad
title_short	Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad
title_full	Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad
title_fullStr	Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad
title_full_unstemmed	Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad
title_sort	tuberculosis en individuos con infección por vih en chile: estudio de prevalencia e impacto sobre mortalidad
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000500005
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Tuberculosis en individuos con infección por VIH en Chile: Estudio de prevalencia e impacto sobre mortalidad

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