Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica

Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. Aim: To assess the association between inflammation and ED in CHF. Material...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Greig,Douglas, Castro,Pablo, Gabrielli,Luigi, Miranda,Rodrigo, Verdejo,Hugo, Alcaíno,Hernán, Bustos,Carlos, Chiong,Mario, Godoy,Iván, Mellado,Rosemarie, García,Lorena, Salas,Daniela, Vivar,Raúl, Vukasovic,José Luis, Concepción,Roberto, Díaz-Araya,Guillermo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Endothelium, vascular Heart failure Inflammation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000600001
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872008000600001
record_format	dspace
spelling	oai:scielo:S0034-988720080006000012008-08-26Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónicaGreig,DouglasCastro,PabloGabrielli,LuigiMiranda,RodrigoVerdejo,HugoAlcaíno,HernánBustos,CarlosChiong,MarioGodoy,IvánMellado,RosemarieGarcía,LorenaSalas,DanielaVivar,RaúlVukasovic,José LuisConcepción,RobertoDíaz-Araya,Guillermo Endothelium, vascular Heart failure Inflammation Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. Aim: To assess the association between inflammation and ED in CHF. Material and methods: Forty two patients aged 56±14 years (80% male) with a CHF in functional capacity II-III (New York Heart Association) and an ejection fraction (FE) <40% were consecutively studied. Patients were classified according to the presence or absence of ED, evaluated by reactive vasodilation measured by ultrasound, after brachial artery compression. Circulating levels of highly sensitive C reactive protein (usCRP), tumor necrosis factor a (TNFá) and interleukin-6 (IL-6) were determined by ELISA. A group of 15 healthy subjects of similar age, were studied as controls. Results: Sixty seven percent of patients had ED. Compared to controls, patients with CHF had higher usCRP (0.58±0.4 and 4.9±7.1 mg/dl respectively, p <0.01) and IL-6 (1.38±0.06 and 3.1±1.7 mg/dl respectively, p <0.01). Compared to patients without ED, patients with CHF and ED had higher levéis of usCRP (3.0±0.4 and 6.0±5.7 mg/dl respectively, p <0.01) and TNFá (0.31±0.26 and 1.0±1.1 pg/ml, p =0.02). No differences in IL-6 were found between CHF groups. Conclusions: In CHF patients, the presence of ED was associated with increased levéis of inflammatory markersinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.6 20082008-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000600001es10.4067/S0034-98872008000600001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Endothelium, vascular Heart failure Inflammation
spellingShingle	Endothelium, vascular Heart failure Inflammation Greig,Douglas Castro,Pablo Gabrielli,Luigi Miranda,Rodrigo Verdejo,Hugo Alcaíno,Hernán Bustos,Carlos Chiong,Mario Godoy,Iván Mellado,Rosemarie García,Lorena Salas,Daniela Vivar,Raúl Vukasovic,José Luis Concepción,Roberto Díaz-Araya,Guillermo Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
description	Background: In chronic heart failure (CHF), endothelial dysfunction (ED) is a consequence of an imbalance of vascular tone regulating substances. The relationship between ED and inflammation has not been fully investigated. Aim: To assess the association between inflammation and ED in CHF. Material and methods: Forty two patients aged 56±14 years (80% male) with a CHF in functional capacity II-III (New York Heart Association) and an ejection fraction (FE) <40% were consecutively studied. Patients were classified according to the presence or absence of ED, evaluated by reactive vasodilation measured by ultrasound, after brachial artery compression. Circulating levels of highly sensitive C reactive protein (usCRP), tumor necrosis factor a (TNFá) and interleukin-6 (IL-6) were determined by ELISA. A group of 15 healthy subjects of similar age, were studied as controls. Results: Sixty seven percent of patients had ED. Compared to controls, patients with CHF had higher usCRP (0.58±0.4 and 4.9±7.1 mg/dl respectively, p <0.01) and IL-6 (1.38±0.06 and 3.1±1.7 mg/dl respectively, p <0.01). Compared to patients without ED, patients with CHF and ED had higher levéis of usCRP (3.0±0.4 and 6.0±5.7 mg/dl respectively, p <0.01) and TNFá (0.31±0.26 and 1.0±1.1 pg/ml, p =0.02). No differences in IL-6 were found between CHF groups. Conclusions: In CHF patients, the presence of ED was associated with increased levéis of inflammatory markers
author	Greig,Douglas Castro,Pablo Gabrielli,Luigi Miranda,Rodrigo Verdejo,Hugo Alcaíno,Hernán Bustos,Carlos Chiong,Mario Godoy,Iván Mellado,Rosemarie García,Lorena Salas,Daniela Vivar,Raúl Vukasovic,José Luis Concepción,Roberto Díaz-Araya,Guillermo
author_facet	Greig,Douglas Castro,Pablo Gabrielli,Luigi Miranda,Rodrigo Verdejo,Hugo Alcaíno,Hernán Bustos,Carlos Chiong,Mario Godoy,Iván Mellado,Rosemarie García,Lorena Salas,Daniela Vivar,Raúl Vukasovic,José Luis Concepción,Roberto Díaz-Araya,Guillermo
author_sort	Greig,Douglas
title	Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
title_short	Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
title_full	Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
title_fullStr	Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
title_full_unstemmed	Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
title_sort	inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000600001
work_keys_str_mv	AT greigdouglas inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT castropablo inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT gabrielliluigi inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT mirandarodrigo inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT verdejohugo inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT alcainohernan inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT bustoscarlos inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT chiongmario inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT godoyivan inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT melladorosemarie inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT garcialorena inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT salasdaniela inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT vivarraul inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT vukasovicjoseluis inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT concepcionroberto inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica AT diazarayaguillermo inflamacionydisfuncionendotelialenpacientesconinsuficienciacardiacacronica
_version_	1718436382131617792

Inflamación y disfunción endotelial en pacientes con insuficiencia cardiaca crónica

Ejemplares similares