Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios

Background: Myocardial revascularization surgery has used several vessels as coronary grafts including internal mammary and radial arteries which have a better prognosis than saphenous vein. Their long-term patency has been associated with the reléase of endothelium vasodilator and anti-aggregating...

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Autores principales:	Guivernau,Mauricio, Berr,Miguel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Diabetes complications Coronary artery disease Epoprostenol Mammary arteries Radial artery
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700001
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spelling	oai:scielo:S0034-988720080007000012008-09-04Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronariosGuivernau,MauricioBerr,Miguel Diabetes complications Coronary artery disease Epoprostenol Mammary arteries Radial artery Background: Myocardial revascularization surgery has used several vessels as coronary grafts including internal mammary and radial arteries which have a better prognosis than saphenous vein. Their long-term patency has been associated with the reléase of endothelium vasodilator and anti-aggregating producís such as prostacyclin. Diabetes induces endothelial dysfunction and a high number of diabetics require revascularization. Aim: To assess the capacity to synthesize prostacyclin of different vessels from diabetics. Material and methods: Internal mammary and radial arteries and saphenous veins obtained from 10 diabetic and 10 non diabetic patients subjected to coronary artery bypass surgery were studied. The capacity to synthesize prostacyclin was assessed in these vessels measuríng its hydrolysis product, the 6-keto-PGFla by radioimmunoassay. Results: Internal mammary arteries and saphenous veins from diabetics synthesized a lower amount of prostacyclin than those from non-diabetics. The radial artery produced similar amounts of prostacyclin in both groups. This response was associated with an increase of the conversión of the precursor arachidonic acid to prostacyclin. The saturating concentrations of this acid required to achieve the maximal stimulation were higher in the radial artery (20 µM) than in the internal mammary artery and saphenous vein (10 µM), suggesting that the enzymatic activity of the radial artery was not affected by diabetes. Conclusions: The radial artery appears as the best replacement vessel for coronary surgery in diabetics. Its favorable biochemical profile and potential lower long-term occlusion rate may be relevant for a better prognosis of myocardial revascularization in these patientsinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.7 20082008-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700001es10.4067/S0034-98872008000700001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Diabetes complications Coronary artery disease Epoprostenol Mammary arteries Radial artery
spellingShingle	Diabetes complications Coronary artery disease Epoprostenol Mammary arteries Radial artery Guivernau,Mauricio Berr,Miguel Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios
description	Background: Myocardial revascularization surgery has used several vessels as coronary grafts including internal mammary and radial arteries which have a better prognosis than saphenous vein. Their long-term patency has been associated with the reléase of endothelium vasodilator and anti-aggregating producís such as prostacyclin. Diabetes induces endothelial dysfunction and a high number of diabetics require revascularization. Aim: To assess the capacity to synthesize prostacyclin of different vessels from diabetics. Material and methods: Internal mammary and radial arteries and saphenous veins obtained from 10 diabetic and 10 non diabetic patients subjected to coronary artery bypass surgery were studied. The capacity to synthesize prostacyclin was assessed in these vessels measuríng its hydrolysis product, the 6-keto-PGFla by radioimmunoassay. Results: Internal mammary arteries and saphenous veins from diabetics synthesized a lower amount of prostacyclin than those from non-diabetics. The radial artery produced similar amounts of prostacyclin in both groups. This response was associated with an increase of the conversión of the precursor arachidonic acid to prostacyclin. The saturating concentrations of this acid required to achieve the maximal stimulation were higher in the radial artery (20 µM) than in the internal mammary artery and saphenous vein (10 µM), suggesting that the enzymatic activity of the radial artery was not affected by diabetes. Conclusions: The radial artery appears as the best replacement vessel for coronary surgery in diabetics. Its favorable biochemical profile and potential lower long-term occlusion rate may be relevant for a better prognosis of myocardial revascularization in these patients
author	Guivernau,Mauricio Berr,Miguel
author_facet	Guivernau,Mauricio Berr,Miguel
author_sort	Guivernau,Mauricio
title	Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios
title_short	Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios
title_full	Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios
title_fullStr	Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios
title_full_unstemmed	Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios
title_sort	producción de prostaciclina en arteria radial de diabéticos: comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700001
work_keys_str_mv	AT guivernaumauricio producciondeprostaciclinaenarteriaradialdediabeticoscomparacionconlavenasafenayarteriamamariainternaysurelevanciaenelpronosticodeestosbypasscoronarios AT berrmiguel producciondeprostaciclinaenarteriaradialdediabeticoscomparacionconlavenasafenayarteriamamariainternaysurelevanciaenelpronosticodeestosbypasscoronarios
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Producción de prostaciclina en arteria radial de diabéticos: Comparación con la vena safena y arteria mamaria interna y su relevancia en el pronóstico de estos bypass coronarios

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