Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado

Background: Overall 5 years survival for surgically excised gastric cancer is 30%. Adjuvant treatment may improve the surgical results. Aim: To assess treatment results and toxicity in patients with surgically excised gastric cancer, treated with adjuvant radiotherapy and concomitant continuous 5-Fl...

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Autores principales:	Garrido,Marcelo, Bustos,Marisa, Orellana,Eric, Madrid,Jorge, Galindo,Héctor, Sánchez,César, Pimentel,Fernando, Guzmán,Sergio, Ibáñez,Luis, Butte,Jean Michel, Álvarez,Manuel, Besa,Pelayo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Chemotherapy, adjuvant Radiotherapy, adjuvant Stomach neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700004
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spelling	oai:scielo:S0034-988720080007000042008-09-04Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzadoGarrido,MarceloBustos,MarisaOrellana,EricMadrid,JorgeGalindo,HéctorSánchez,CésarPimentel,FernandoGuzmán,SergioIbáñez,LuisButte,Jean MichelÁlvarez,ManuelBesa,Pelayo Chemotherapy, adjuvant Radiotherapy, adjuvant Stomach neoplasms Background: Overall 5 years survival for surgically excised gastric cancer is 30%. Adjuvant treatment may improve the surgical results. Aim: To assess treatment results and toxicity in patients with surgically excised gastric cancer, treated with adjuvant radiotherapy and concomitant continuous 5-Fluorouracil (5-FU). Material and Methods: Forty one patients aged 32 to 73 years (29 males) with stage II-IVA gastric cancer, subjected to a total or subtotal gastrectomy and D2 nodal dissection between 1997 to 2006, were studied. They received adjuvant radiotherapy to the gastríc bed and draining ¡ymphatic nodes in a total dose of 50.4 Gy in 28 fractions and chemotherapy with continuous infusión 5-FU, 200 mg/m²/day. Results were compared to historical controls matched according to demographic parameters and tumor characterístics. Results: Eighteen patients were in stage II, 10 in stage IIIA, nine in stage IIIB and four in stage IVA. Twelve patients had an NO nodal status, 15 were NI, nine were N2 and five were N3. After a mean follow up of 32 months, 26 patients (63%) were alive. Five year overall survival was 49.6% for surgery plus radiochemotherapy compared to 30.7% for the historical group subjected only to surgery (p =0.002). Radiotherapy was associated with grade 1-2 toxicity and treatment was completed without interruptions in all patients. Chemotherapy was delayed temporaríly in 3 patients. Conclusions: Adjuvant radio-chemotherapy improved overall survival in gastríc cancer, compared to historical controls subjected only to surgical treatmentinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.7 20082008-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700004es10.4067/S0034-98872008000700004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Chemotherapy, adjuvant Radiotherapy, adjuvant Stomach neoplasms
spellingShingle	Chemotherapy, adjuvant Radiotherapy, adjuvant Stomach neoplasms Garrido,Marcelo Bustos,Marisa Orellana,Eric Madrid,Jorge Galindo,Héctor Sánchez,César Pimentel,Fernando Guzmán,Sergio Ibáñez,Luis Butte,Jean Michel Álvarez,Manuel Besa,Pelayo Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado
description	Background: Overall 5 years survival for surgically excised gastric cancer is 30%. Adjuvant treatment may improve the surgical results. Aim: To assess treatment results and toxicity in patients with surgically excised gastric cancer, treated with adjuvant radiotherapy and concomitant continuous 5-Fluorouracil (5-FU). Material and Methods: Forty one patients aged 32 to 73 years (29 males) with stage II-IVA gastric cancer, subjected to a total or subtotal gastrectomy and D2 nodal dissection between 1997 to 2006, were studied. They received adjuvant radiotherapy to the gastríc bed and draining ¡ymphatic nodes in a total dose of 50.4 Gy in 28 fractions and chemotherapy with continuous infusión 5-FU, 200 mg/m²/day. Results were compared to historical controls matched according to demographic parameters and tumor characterístics. Results: Eighteen patients were in stage II, 10 in stage IIIA, nine in stage IIIB and four in stage IVA. Twelve patients had an NO nodal status, 15 were NI, nine were N2 and five were N3. After a mean follow up of 32 months, 26 patients (63%) were alive. Five year overall survival was 49.6% for surgery plus radiochemotherapy compared to 30.7% for the historical group subjected only to surgery (p =0.002). Radiotherapy was associated with grade 1-2 toxicity and treatment was completed without interruptions in all patients. Chemotherapy was delayed temporaríly in 3 patients. Conclusions: Adjuvant radio-chemotherapy improved overall survival in gastríc cancer, compared to historical controls subjected only to surgical treatment
author	Garrido,Marcelo Bustos,Marisa Orellana,Eric Madrid,Jorge Galindo,Héctor Sánchez,César Pimentel,Fernando Guzmán,Sergio Ibáñez,Luis Butte,Jean Michel Álvarez,Manuel Besa,Pelayo
author_facet	Garrido,Marcelo Bustos,Marisa Orellana,Eric Madrid,Jorge Galindo,Héctor Sánchez,César Pimentel,Fernando Guzmán,Sergio Ibáñez,Luis Butte,Jean Michel Álvarez,Manuel Besa,Pelayo
author_sort	Garrido,Marcelo
title	Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado
title_short	Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado
title_full	Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado
title_fullStr	Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado
title_full_unstemmed	Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado
title_sort	radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700004
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Radio-quimioterapia postoperatoria en cáncer gástrico localmente avanzado

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