Hiperaldosteronismo primario

Primary aldosteronism (PA) is a known cause of hypertension. In the kidney, aldosterone promotes sodium and water reabsorption, increasing the intravascular volume and blood pressure (BP). In the cardiovascular system, aldosterone modifies endothelial and smooth muscle cell response, increasing card...

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Autores principales:	Fardella,Carlos E, Mosso,Lorena M, Carvajal,Cristian A
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Aldosterone Hyperaldosteronism Hypertension
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700014
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spelling	oai:scielo:S0034-988720080007000142008-09-04Hiperaldosteronismo primarioFardella,Carlos EMosso,Lorena MCarvajal,Cristian A Aldosterone Hyperaldosteronism Hypertension Primary aldosteronism (PA) is a known cause of hypertension. In the kidney, aldosterone promotes sodium and water reabsorption, increasing the intravascular volume and blood pressure (BP). In the cardiovascular system, aldosterone modifies endothelial and smooth muscle cell response, increasing cardiovascular risk in a blood pressure-independent way. Recently a high prevalence of PA (near to 10%) in hypertensive population, has been detected measuring plasma aldosterone/renin activity ratio (ARR) as screening test. This ratio increases along with the severity ofthe hypertensive disease. The diagnostic work up of PA should confirm the autonomy of aldosterone secretion from the renin-angiotensin system and should differentiate the clinical subtypes of the disease. These are idiopathic aldosteronism (IA) and aldosterone-producing adenoma (APA). Other causes are familial hyperaldosteronism (FH) type I (glucocorticoid-remediable aldosteronism), FH-II (non glucocorticoid-remediable aldosteronism), primary adrenal hyperplasia and adrenal carcinoma. This article reviews the prevalence, diagnosis and treatment of PA and also the clinical, biochemical and genetic characteristics ofits different subtypesinfo:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.7 20082008-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700014es10.4067/S0034-98872008000700014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aldosterone Hyperaldosteronism Hypertension
spellingShingle	Aldosterone Hyperaldosteronism Hypertension Fardella,Carlos E Mosso,Lorena M Carvajal,Cristian A Hiperaldosteronismo primario
description	Primary aldosteronism (PA) is a known cause of hypertension. In the kidney, aldosterone promotes sodium and water reabsorption, increasing the intravascular volume and blood pressure (BP). In the cardiovascular system, aldosterone modifies endothelial and smooth muscle cell response, increasing cardiovascular risk in a blood pressure-independent way. Recently a high prevalence of PA (near to 10%) in hypertensive population, has been detected measuring plasma aldosterone/renin activity ratio (ARR) as screening test. This ratio increases along with the severity ofthe hypertensive disease. The diagnostic work up of PA should confirm the autonomy of aldosterone secretion from the renin-angiotensin system and should differentiate the clinical subtypes of the disease. These are idiopathic aldosteronism (IA) and aldosterone-producing adenoma (APA). Other causes are familial hyperaldosteronism (FH) type I (glucocorticoid-remediable aldosteronism), FH-II (non glucocorticoid-remediable aldosteronism), primary adrenal hyperplasia and adrenal carcinoma. This article reviews the prevalence, diagnosis and treatment of PA and also the clinical, biochemical and genetic characteristics ofits different subtypes
author	Fardella,Carlos E Mosso,Lorena M Carvajal,Cristian A
author_facet	Fardella,Carlos E Mosso,Lorena M Carvajal,Cristian A
author_sort	Fardella,Carlos E
title	Hiperaldosteronismo primario
title_short	Hiperaldosteronismo primario
title_full	Hiperaldosteronismo primario
title_fullStr	Hiperaldosteronismo primario
title_full_unstemmed	Hiperaldosteronismo primario
title_sort	hiperaldosteronismo primario
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000700014
work_keys_str_mv	AT fardellacarlose hiperaldosteronismoprimario AT mossolorenam hiperaldosteronismoprimario AT carvajalcristiana hiperaldosteronismoprimario
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Hiperaldosteronismo primario

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