Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol

Background: Central reninangiotensin system modulates alcohol intake and inhibition of angiotensin converting enzyme reduces ethanol consumption in rats, and may be potentially useful in the treatment of alcoholism. Aim: To study the effect of captopríl on alcohol intake, both in humans and animals...

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Autores principales:	Guivernau,Mauricio, Pallavicini,Julio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Angiotensin II Captopril Ethanol
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000800002
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spelling	oai:scielo:S0034-988720080008000022009-01-23Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcoholGuivernau,MauricioPallavicini,Julio Angiotensin II Captopril Ethanol Background: Central reninangiotensin system modulates alcohol intake and inhibition of angiotensin converting enzyme reduces ethanol consumption in rats, and may be potentially useful in the treatment of alcoholism. Aim: To study the effect of captopríl on alcohol intake, both in humans and animals . Material and methods: In a double-blind, placebo-controlled clinical study, 15 alcoholics who met DSM-IV criíteria were randomized to receive captopril 100 mg/day or placebo for 12 weeks. In the experimental study, daily consumption of ethanol (10% v/v), water and solid food was assessed in 12 male Wistar rats before and after the intraperítoneal administration of captopríl 50 mg/kg/day. Results: In alcoholics, mean weekly standard alcoholic drínk consumption was not different during captopríl treatment or placebo. However, both groups had a signiñcantly lower intake than duríng baseline. Days of abstinence increased and days of drunkeness decreased in the group receiving captopril, when compared with baseline but not with placebo. Craving was significantly reduced by captopríl when compared with placebo. In rats, captopríl reduced not only alcohol consumption but also water and food intake. Conclusions: Captopríl decreases alcohol intake in rats and this effect is not speciñc for ethanol. Captopril did not alter alcohol consumption in alcoholics when compared with placebo but reduced craving.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.8 20082008-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000800002es10.4067/S0034-98872008000800002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Angiotensin II Captopril Ethanol
spellingShingle	Angiotensin II Captopril Ethanol Guivernau,Mauricio Pallavicini,Julio Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol
description	Background: Central reninangiotensin system modulates alcohol intake and inhibition of angiotensin converting enzyme reduces ethanol consumption in rats, and may be potentially useful in the treatment of alcoholism. Aim: To study the effect of captopríl on alcohol intake, both in humans and animals . Material and methods: In a double-blind, placebo-controlled clinical study, 15 alcoholics who met DSM-IV criíteria were randomized to receive captopril 100 mg/day or placebo for 12 weeks. In the experimental study, daily consumption of ethanol (10% v/v), water and solid food was assessed in 12 male Wistar rats before and after the intraperítoneal administration of captopríl 50 mg/kg/day. Results: In alcoholics, mean weekly standard alcoholic drínk consumption was not different during captopríl treatment or placebo. However, both groups had a signiñcantly lower intake than duríng baseline. Days of abstinence increased and days of drunkeness decreased in the group receiving captopril, when compared with baseline but not with placebo. Craving was significantly reduced by captopríl when compared with placebo. In rats, captopríl reduced not only alcohol consumption but also water and food intake. Conclusions: Captopríl decreases alcohol intake in rats and this effect is not speciñc for ethanol. Captopril did not alter alcohol consumption in alcoholics when compared with placebo but reduced craving.
author	Guivernau,Mauricio Pallavicini,Julio
author_facet	Guivernau,Mauricio Pallavicini,Julio
author_sort	Guivernau,Mauricio
title	Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol
title_short	Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol
title_full	Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol
title_fullStr	Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol
title_full_unstemmed	Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol
title_sort	efecto de la inhibición de la síntesis de angiotensina ii en el consumo de alcohol
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008000800002
work_keys_str_mv	AT guivernaumauricio efectodelainhibiciondelasintesisdeangiotensinaiienelconsumodealcohol AT pallavicinijulio efectodelainhibiciondelasintesisdeangiotensinaiienelconsumodealcohol
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Efecto de la inhibición de la síntesis de angiotensina II en el consumo de alcohol

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