Síndrome hemolítico urémico en Chile: presentación clínica, evolución y factores pronósticos

Síndrome hemolítico urémico en Chile: presentación clínica, evolución y factores pronósticos

Background: Hemolytic-uremic syndrome (HUS) is characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Aim: To describe the characteñstics ofpatients with the diagnosis ofHUS in Chile, and to identify the most reliable early predictors oímorbidity and moñality....

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Autores principales: Zambrano O,Pedro, Delucchi B,Angela, Cavagnaro S,Felipe, Hevia J,Pilar, Rosati M,María Pía, Lagos R,Elizabeth, Nazal Ch,Vilma, González C,Claudia, Barrera B,Patricia, Alvarez L,Enrique, Pinto S,Viola, Salas del C,Paulina, Cano Sen,Francisco, Contreras M,Angélica, Galanti de la P,Mónica, Gana A,Juan Cristóbal, Zamorano C,Julio, Espinoza B,Amelia, Dreves R,Patricia, Pereira M,Jaime, Bidegain S,Antonia, Pasten P,Erna, Yáñez P,Leticia, Cerda F,Verónica, Rodríguez S,Eugenio, Aglony I,Marlene, Gutiérrez I,Elisa, Salas P,Francisca, Figueroa Y,Sonia, Valenzuela A,Marcela, Grandy H,Jean, Guerra A,Boris, Lapadula A,Michelangelo, Reutter de la M,Paula, Gallardo T,Vivian, Maldonado S,Douglas, Azocar P,Marta, Cavada Ch,Gabriel
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2008
Materias:
Escherichia coli
Hemolytic-uremic syndrome
Kidney failure, acute
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008001000002
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Sumario:Background: Hemolytic-uremic syndrome (HUS) is characterized by acute renal failure, microangiopathic hemolytic anemia and thrombocytopenia. Aim: To describe the characteñstics ofpatients with the diagnosis ofHUS in Chile, and to identify the most reliable early predictors oímorbidity and moñality. Material and methods: The clinical records ofpatients with HUS aged less than 15 years, attended between January 1990 and December 2003 in 15 hospitals, were reviewed. Demographic, clinical, biochemical, hematological parameters, morbidity and mortality were analyzed. Results: A cohort of 587 patients aged 2 to 8 years, 48% males, was analyzed. Ninety two percent had diarrhea. At the moment of diagnosis, anuria was observed in 39% of the patients, hypertension in 45% and seizures in 17%. Forty two percent required renal replacement therapy (RRT) and perítoneal dialysis was used in the majoríty of cases (78%). The most frequently isolated etiological agentwas Escherichia coli. Mortality rate was 2.9% in the acute phase of the disease and there was a positive correlation between mortality and anuria, seizures, white blood cell count (WCC) >20.000/mm³ and requirements of renal replacement therapy (p <0.05). Twelve percent of patients evolved to chronic renal failure and the risk factors during the acute phase were the need for renal replacement therapy, anuria, WCC >20.000/mm³, seizures and hypertension. Conclusions: The present study emphasizes important clinical and epidemiological aspeets ofHUSin a Chilean pediatricpopulation.

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