Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario

Background: Orthotopic liver transplantation (OLT) is the treatment of choice for multiple acute and chronic end-stage liver diseases as well as for selected cases of liver malignancy and ¡iver-site metabolic disorders. Neurological impairment is a major source of morbidity and moñality following OL...

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Autores principales:	Mellado,Patricio, Peredo,Pilar, Valenzuela,Raúl, Arrese,Marco, Pérez,Rosa María, Domínguez,Pilar, Guerra,Juan Francisco, Jarufe,Nicolás, Martínez,Jorge
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Cerebrovascular disease Liver transplantation Myelinolysis central pontine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008001000004
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spelling	oai:scielo:S0034-988720080010000042009-01-15Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitarioMellado,PatricioPeredo,PilarValenzuela,RaúlArrese,MarcoPérez,Rosa MaríaDomínguez,PilarGuerra,Juan FranciscoJarufe,NicolásMartínez,Jorge Cerebrovascular disease Liver transplantation Myelinolysis central pontine Background: Orthotopic liver transplantation (OLT) is the treatment of choice for multiple acute and chronic end-stage liver diseases as well as for selected cases of liver malignancy and ¡iver-site metabolic disorders. Neurological impairment is a major source of morbidity and moñality following OLT. Aim: To describe the incidence and the type of neurological complications occurring in the post-operative period of OLT in patients transplanted in our hospital. Material and methods: Between March 1994 and August 2007, 76 adult patients underwent OLT. Data on incidence, time of onset, and outcome of central nervous system (CNS) complications have been obtained from our program data base and patient charts. Results: Twenty three patients (30.3%) had CNS complications following OLT. The leading complications were immunosuppressive drug-related neurological impairment in nine patients (39.1%), peripheral nerve damage in five patients (21.7%), central pontine myelinolysis in four patients (17.4%), cerebrovascular disease in three (13%) and CNS infection in three (13%). Most CNS events (90%) occurred in the first 2 weeks after OLT. Five patients with neurological complications died (22%). Conclusions: CNS complications occurred in almost one fifth of the population studied, and they had a poor outcome, as previously reported).info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.10 20082008-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008001000004es10.4067/S0034-98872008001000004
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cerebrovascular disease Liver transplantation Myelinolysis central pontine
spellingShingle	Cerebrovascular disease Liver transplantation Myelinolysis central pontine Mellado,Patricio Peredo,Pilar Valenzuela,Raúl Arrese,Marco Pérez,Rosa María Domínguez,Pilar Guerra,Juan Francisco Jarufe,Nicolás Martínez,Jorge Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario
description	Background: Orthotopic liver transplantation (OLT) is the treatment of choice for multiple acute and chronic end-stage liver diseases as well as for selected cases of liver malignancy and ¡iver-site metabolic disorders. Neurological impairment is a major source of morbidity and moñality following OLT. Aim: To describe the incidence and the type of neurological complications occurring in the post-operative period of OLT in patients transplanted in our hospital. Material and methods: Between March 1994 and August 2007, 76 adult patients underwent OLT. Data on incidence, time of onset, and outcome of central nervous system (CNS) complications have been obtained from our program data base and patient charts. Results: Twenty three patients (30.3%) had CNS complications following OLT. The leading complications were immunosuppressive drug-related neurological impairment in nine patients (39.1%), peripheral nerve damage in five patients (21.7%), central pontine myelinolysis in four patients (17.4%), cerebrovascular disease in three (13%) and CNS infection in three (13%). Most CNS events (90%) occurred in the first 2 weeks after OLT. Five patients with neurological complications died (22%). Conclusions: CNS complications occurred in almost one fifth of the population studied, and they had a poor outcome, as previously reported).
author	Mellado,Patricio Peredo,Pilar Valenzuela,Raúl Arrese,Marco Pérez,Rosa María Domínguez,Pilar Guerra,Juan Francisco Jarufe,Nicolás Martínez,Jorge
author_facet	Mellado,Patricio Peredo,Pilar Valenzuela,Raúl Arrese,Marco Pérez,Rosa María Domínguez,Pilar Guerra,Juan Francisco Jarufe,Nicolás Martínez,Jorge
author_sort	Mellado,Patricio
title	Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario
title_short	Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario
title_full	Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario
title_fullStr	Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario
title_full_unstemmed	Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario
title_sort	complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: experiencia de un centro universitario
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008001000004
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Complicaciones neurológicas en pacientes adultos sometidos a trasplante hepático ortotópico: Experiencia de un centro universitario

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