Daño vascular en la enfermedad renal crónica

Cardiovascular disease is a frequent complication of renal failure and is the most common cause of death in patients with chronic kidney disease (CKD). Accelerated atherogenesis has been widely documented in CKD and diabetic nephropathy is the leading cause of renal failure worldwide. Furthermore, C...

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Autores principales:	Jara,Aquiles, Mezzano,Sergio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2008
Materias:	Atherosclerosis Cardiovascular diseases Diabetic nephropathies Kidney diseases
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008001100016
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spelling	oai:scielo:S0034-988720080011000162009-03-23Daño vascular en la enfermedad renal crónicaJara,AquilesMezzano,Sergio Atherosclerosis Cardiovascular diseases Diabetic nephropathies Kidney diseases Cardiovascular disease is a frequent complication of renal failure and is the most common cause of death in patients with chronic kidney disease (CKD). Accelerated atherogenesis has been widely documented in CKD and diabetic nephropathy is the leading cause of renal failure worldwide. Furthermore, CKD promotes hypertension and dyslipidemia, which in turn may contribute to the progression of renal failure. All together, hypertension, dyslipidemia and diabetes are considered major risk factors for the development of endothelial dysfunction and progression of atherosclerosis. Elevated inflammatory mediators and activation of the renin-angiotensin system contribute through enhanced production of reactive oxygen species, to atherogenesis in CKD. Vascular calcification is also important. Calcification of arteries occurs in the intima in association with atherosclerosis, where it may contribute to plaque formation, and in the media, where it causes stiffening. Increased serum levels of calcification promoters, such as hyperphosphatemia, and a decrease in circulating and local inhibitors of calcification, favor vascular calcification. On the other hand, transdifferentiation of vascular smooth muscle cells to osteblast-like cells would be the pivotal event in calcification. Bone morphogenetic protein agonists and antagonists are playing a role in this osteogenic differentiation. Accelerated atherosclerosis and media calcification will then lead to increased prevalence of coronary artery disease, heart failure, stroke, and peripheral arterial disease. Prevention and treatment of cardiovascular disease are major considerations in the management of individuals with CKD .info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.136 n.11 20082008-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008001100016es10.4067/S0034-98872008001100016
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Atherosclerosis Cardiovascular diseases Diabetic nephropathies Kidney diseases
spellingShingle	Atherosclerosis Cardiovascular diseases Diabetic nephropathies Kidney diseases Jara,Aquiles Mezzano,Sergio Daño vascular en la enfermedad renal crónica
description	Cardiovascular disease is a frequent complication of renal failure and is the most common cause of death in patients with chronic kidney disease (CKD). Accelerated atherogenesis has been widely documented in CKD and diabetic nephropathy is the leading cause of renal failure worldwide. Furthermore, CKD promotes hypertension and dyslipidemia, which in turn may contribute to the progression of renal failure. All together, hypertension, dyslipidemia and diabetes are considered major risk factors for the development of endothelial dysfunction and progression of atherosclerosis. Elevated inflammatory mediators and activation of the renin-angiotensin system contribute through enhanced production of reactive oxygen species, to atherogenesis in CKD. Vascular calcification is also important. Calcification of arteries occurs in the intima in association with atherosclerosis, where it may contribute to plaque formation, and in the media, where it causes stiffening. Increased serum levels of calcification promoters, such as hyperphosphatemia, and a decrease in circulating and local inhibitors of calcification, favor vascular calcification. On the other hand, transdifferentiation of vascular smooth muscle cells to osteblast-like cells would be the pivotal event in calcification. Bone morphogenetic protein agonists and antagonists are playing a role in this osteogenic differentiation. Accelerated atherosclerosis and media calcification will then lead to increased prevalence of coronary artery disease, heart failure, stroke, and peripheral arterial disease. Prevention and treatment of cardiovascular disease are major considerations in the management of individuals with CKD .
author	Jara,Aquiles Mezzano,Sergio
author_facet	Jara,Aquiles Mezzano,Sergio
author_sort	Jara,Aquiles
title	Daño vascular en la enfermedad renal crónica
title_short	Daño vascular en la enfermedad renal crónica
title_full	Daño vascular en la enfermedad renal crónica
title_fullStr	Daño vascular en la enfermedad renal crónica
title_full_unstemmed	Daño vascular en la enfermedad renal crónica
title_sort	daño vascular en la enfermedad renal crónica
publisher	Sociedad Médica de Santiago
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872008001100016
work_keys_str_mv	AT jaraaquiles danovascularenlaenfermedadrenalcronica AT mezzanosergio danovascularenlaenfermedadrenalcronica
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Daño vascular en la enfermedad renal crónica

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