Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones

Background: During 2005, the surveillance system of the Chilean Immunization Program detected an increased number of adverse reaction notifications associated to diphtheria, pertussis and tetanus whole-cell vaccine (DPT), coincidentiy with a change in the vaccine manufacturer. Aim: To compare the re...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Abarca V,Katia, Cerda L,Jaime, Ferreccio R,Catterina
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Adverse drug reaction reporting system Bacterial vaccines Diphtheria-tetanus-pertussis vaccine
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000100002
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872009000100002
record_format	dspace
spelling	oai:scielo:S0034-988720090001000022009-04-13Reacciones adversas a vacuna DPT del Programa Nacional de InmunizacionesAbarca V,KatiaCerda L,JaimeFerreccio R,Catterina Adverse drug reaction reporting system Bacterial vaccines Diphtheria-tetanus-pertussis vaccine Background: During 2005, the surveillance system of the Chilean Immunization Program detected an increased number of adverse reaction notifications associated to diphtheria, pertussis and tetanus whole-cell vaccine (DPT), coincidentiy with a change in the vaccine manufacturer. Aim: To compare the reactogenicity of two DPT formulations (vaccines 1 and 2) in 18-month-old infants and 4-year-old children. Material and methods: Severe adverse reactions to DPT were studied at the emergency room of two hospitals of Santiago in a case-control study (110 cases and 171 controls, who consulted for other causes). Simultaneously the incidence of total adverse reactions (mild and severe) for vaccine 1 and 2 was estimated in a cohort of 1,017 children vaccinated in an ambulatory health center of the same área. The formulation of DPT received by all participants was verífied, as well as the temporal relation with consultation or symptoms referred by their caregivers. Results: There was a greater probability of consulting at the emergency rooms for severe adverse reactions among children who received vaccine 1 (odds ratio (OR) =7.1; p <0.001), being greater among 4-year-old children (OR =18.9; p <0.001). Coincidentiy, in the cohort of vaccinated children, those who received vaccine 1 had a higher risk of presenting adverse reactions (RR =2.9; p <0.001), being high fever the commonest. Conclusions: We confirmed that vaccine 1 was associated to a higher risk of adverse reactions, especially among 4-year-old children. These results allowed the sanitary authority to adopt an informed decisión. The usefulness of observational studies in vaccine adverse reactions is confirmed.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.1 20092009-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000100002es10.4067/S0034-98872009000100002
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adverse drug reaction reporting system Bacterial vaccines Diphtheria-tetanus-pertussis vaccine
spellingShingle	Adverse drug reaction reporting system Bacterial vaccines Diphtheria-tetanus-pertussis vaccine Abarca V,Katia Cerda L,Jaime Ferreccio R,Catterina Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones
description	Background: During 2005, the surveillance system of the Chilean Immunization Program detected an increased number of adverse reaction notifications associated to diphtheria, pertussis and tetanus whole-cell vaccine (DPT), coincidentiy with a change in the vaccine manufacturer. Aim: To compare the reactogenicity of two DPT formulations (vaccines 1 and 2) in 18-month-old infants and 4-year-old children. Material and methods: Severe adverse reactions to DPT were studied at the emergency room of two hospitals of Santiago in a case-control study (110 cases and 171 controls, who consulted for other causes). Simultaneously the incidence of total adverse reactions (mild and severe) for vaccine 1 and 2 was estimated in a cohort of 1,017 children vaccinated in an ambulatory health center of the same área. The formulation of DPT received by all participants was verífied, as well as the temporal relation with consultation or symptoms referred by their caregivers. Results: There was a greater probability of consulting at the emergency rooms for severe adverse reactions among children who received vaccine 1 (odds ratio (OR) =7.1; p <0.001), being greater among 4-year-old children (OR =18.9; p <0.001). Coincidentiy, in the cohort of vaccinated children, those who received vaccine 1 had a higher risk of presenting adverse reactions (RR =2.9; p <0.001), being high fever the commonest. Conclusions: We confirmed that vaccine 1 was associated to a higher risk of adverse reactions, especially among 4-year-old children. These results allowed the sanitary authority to adopt an informed decisión. The usefulness of observational studies in vaccine adverse reactions is confirmed.
author	Abarca V,Katia Cerda L,Jaime Ferreccio R,Catterina
author_facet	Abarca V,Katia Cerda L,Jaime Ferreccio R,Catterina
author_sort	Abarca V,Katia
title	Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones
title_short	Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones
title_full	Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones
title_fullStr	Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones
title_full_unstemmed	Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones
title_sort	reacciones adversas a vacuna dpt del programa nacional de inmunizaciones
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000100002
work_keys_str_mv	AT abarcavkatia reaccionesadversasavacunadptdelprogramanacionaldeinmunizaciones AT cerdaljaime reaccionesadversasavacunadptdelprogramanacionaldeinmunizaciones AT ferrecciorcatterina reaccionesadversasavacunadptdelprogramanacionaldeinmunizaciones
_version_	1718436419619258368

Reacciones adversas a vacuna DPT del Programa Nacional de Inmunizaciones

Ejemplares similares