Morbid obesity in an adolescent with Prader-Willi syndrome

Prader- Willi syndrome is an uncommon multisystem genetic disorder caused by defects of chromosome 15 (15qll-ql3), often due to deletions or uniparental disomy The syndrome is characterized by neonatal hypotonia, dysmorphic facial features, short stature, motor and mental disabilities, behavioral ch...

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Autores principales:	Santos,Vitorino Modesto dos, Henrique de Paula,Fernando, Osterne,Ernesto Misael Cintra, Nery,Natalia Solón, Turra,Thiago Zavascki
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Edema Fluoxetine Obesity, morbid Prader-Willi syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200012
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spelling	oai:scielo:S0034-988720090002000122009-06-10Morbid obesity in an adolescent with Prader-Willi syndromeSantos,Vitorino Modesto dosHenrique de Paula,FernandoOsterne,Ernesto Misael CintraNery,Natalia SolónTurra,Thiago Zavascki Edema Fluoxetine Obesity, morbid Prader-Willi syndrome Prader- Willi syndrome is an uncommon multisystem genetic disorder caused by defects of chromosome 15 (15qll-ql3), often due to deletions or uniparental disomy The syndrome is characterized by neonatal hypotonia, dysmorphic facial features, short stature, motor and mental disabilities, behavioral changes, hyperphagia, precocious obesity and hypogonadotropic hypogonadism. We present a 17year-old woman, with a previous genetic diagnosis of Prader-Willi syndrome and BMI of 74 Kg/m², that was admitted in anasarca, with marked cyanosis, dyspnea and oliguria. She presented high levels ofblood urea, creatinine and aminotransferases, in addition to hyperkalemia and hyperuricemia. She had been in regular use of fluoxetine during the last six months, and evolved with severe high bloodpressure and respiratory failure, which needed intensive care support. Moreover, sequéis and clear signs of recent selfinjuries were observed in her trunk, forearms and hands. The findings of morbid obesity, anasarca, self-injury, hyperuricemia and hypoxemia in Prader- Willi syndrome are emphasized.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.2 20092009-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200012en10.4067/S0034-98872009000200012
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Edema Fluoxetine Obesity, morbid Prader-Willi syndrome
spellingShingle	Edema Fluoxetine Obesity, morbid Prader-Willi syndrome Santos,Vitorino Modesto dos Henrique de Paula,Fernando Osterne,Ernesto Misael Cintra Nery,Natalia Solón Turra,Thiago Zavascki Morbid obesity in an adolescent with Prader-Willi syndrome
description	Prader- Willi syndrome is an uncommon multisystem genetic disorder caused by defects of chromosome 15 (15qll-ql3), often due to deletions or uniparental disomy The syndrome is characterized by neonatal hypotonia, dysmorphic facial features, short stature, motor and mental disabilities, behavioral changes, hyperphagia, precocious obesity and hypogonadotropic hypogonadism. We present a 17year-old woman, with a previous genetic diagnosis of Prader-Willi syndrome and BMI of 74 Kg/m², that was admitted in anasarca, with marked cyanosis, dyspnea and oliguria. She presented high levels ofblood urea, creatinine and aminotransferases, in addition to hyperkalemia and hyperuricemia. She had been in regular use of fluoxetine during the last six months, and evolved with severe high bloodpressure and respiratory failure, which needed intensive care support. Moreover, sequéis and clear signs of recent selfinjuries were observed in her trunk, forearms and hands. The findings of morbid obesity, anasarca, self-injury, hyperuricemia and hypoxemia in Prader- Willi syndrome are emphasized.
author	Santos,Vitorino Modesto dos Henrique de Paula,Fernando Osterne,Ernesto Misael Cintra Nery,Natalia Solón Turra,Thiago Zavascki
author_facet	Santos,Vitorino Modesto dos Henrique de Paula,Fernando Osterne,Ernesto Misael Cintra Nery,Natalia Solón Turra,Thiago Zavascki
author_sort	Santos,Vitorino Modesto dos
title	Morbid obesity in an adolescent with Prader-Willi syndrome
title_short	Morbid obesity in an adolescent with Prader-Willi syndrome
title_full	Morbid obesity in an adolescent with Prader-Willi syndrome
title_fullStr	Morbid obesity in an adolescent with Prader-Willi syndrome
title_full_unstemmed	Morbid obesity in an adolescent with Prader-Willi syndrome
title_sort	morbid obesity in an adolescent with prader-willi syndrome
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200012
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Morbid obesity in an adolescent with Prader-Willi syndrome

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