Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática
Hepatitis C virus (HCV) infection represents a global health problem due to its evolution to hepatic cirrhosis and hepatocellular carcinoma. The viral pathogenesis and infectious processes are not yet fully understood. The development of natural viral resistance towards the host immune system repres...
Guardado en:
Autores principales: | , , |
---|---|
Lenguaje: | Spanish / Castilian |
Publicado: |
Sociedad Médica de Santiago
2009
|
Materias: | |
Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200015 |
Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
id |
oai:scielo:S0034-98872009000200015 |
---|---|
record_format |
dspace |
spelling |
oai:scielo:S0034-988720090002000152009-06-10Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepáticaLugo-Baruqui,AlejandroBautista López,Carlos AlfredoArmendáriz-Borunda,Juan Cirrhosis Fibrosis Hepacivirus Hepatitis C Chroni Hepatitis C virus (HCV) infection represents a global health problem due to its evolution to hepatic cirrhosis and hepatocellular carcinoma. The viral pathogenesis and infectious processes are not yet fully understood. The development of natural viral resistance towards the host immune system represents a mayor challenge for the design of alternative therapeutic interventions and development of viral vaccines. The molecular mechanisms of hepatic fibrosis are well described. New alternatives for the treatment of patients with HCV infection and hepatic cirrhosis are under intensive research. New drugs such as viral protease inhibitors and assembly inhibitors, as well as immune modulators have been studied in clinical trials. Additional alternatives include antifibrotic drugs, which reverse the hepatic cellular damage caused by HCV infection. This review makes reference to viral infective mechanisms, molecular pathways of liver fibrosis and overviews conventional and new treatments for HCV infection and liver fibrosis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.2 20092009-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200015es10.4067/S0034-98872009000200015 |
institution |
Scielo Chile |
collection |
Scielo Chile |
language |
Spanish / Castilian |
topic |
Cirrhosis Fibrosis Hepacivirus Hepatitis C Chroni |
spellingShingle |
Cirrhosis Fibrosis Hepacivirus Hepatitis C Chroni Lugo-Baruqui,Alejandro Bautista López,Carlos Alfredo Armendáriz-Borunda,Juan Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática |
description |
Hepatitis C virus (HCV) infection represents a global health problem due to its evolution to hepatic cirrhosis and hepatocellular carcinoma. The viral pathogenesis and infectious processes are not yet fully understood. The development of natural viral resistance towards the host immune system represents a mayor challenge for the design of alternative therapeutic interventions and development of viral vaccines. The molecular mechanisms of hepatic fibrosis are well described. New alternatives for the treatment of patients with HCV infection and hepatic cirrhosis are under intensive research. New drugs such as viral protease inhibitors and assembly inhibitors, as well as immune modulators have been studied in clinical trials. Additional alternatives include antifibrotic drugs, which reverse the hepatic cellular damage caused by HCV infection. This review makes reference to viral infective mechanisms, molecular pathways of liver fibrosis and overviews conventional and new treatments for HCV infection and liver fibrosis. |
author |
Lugo-Baruqui,Alejandro Bautista López,Carlos Alfredo Armendáriz-Borunda,Juan |
author_facet |
Lugo-Baruqui,Alejandro Bautista López,Carlos Alfredo Armendáriz-Borunda,Juan |
author_sort |
Lugo-Baruqui,Alejandro |
title |
Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática |
title_short |
Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática |
title_full |
Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática |
title_fullStr |
Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática |
title_full_unstemmed |
Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática |
title_sort |
nuevos tratamientos para la infección por virus de hepatitis c y el proceso de fibrosis hepática |
publisher |
Sociedad Médica de Santiago |
publishDate |
2009 |
url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200015 |
work_keys_str_mv |
AT lugobaruquialejandro nuevostratamientosparalainfeccionporvirusdehepatitiscyelprocesodefibrosishepatica AT bautistalopezcarlosalfredo nuevostratamientosparalainfeccionporvirusdehepatitiscyelprocesodefibrosishepatica AT armendarizborundajuan nuevostratamientosparalainfeccionporvirusdehepatitiscyelprocesodefibrosishepatica |
_version_ |
1718436429078462464 |