Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática

Hepatitis C virus (HCV) infection represents a global health problem due to its evolution to hepatic cirrhosis and hepatocellular carcinoma. The viral pathogenesis and infectious processes are not yet fully understood. The development of natural viral resistance towards the host immune system repres...

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Autores principales: Lugo-Baruqui,Alejandro, Bautista López,Carlos Alfredo, Armendáriz-Borunda,Juan
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2009
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200015
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spelling oai:scielo:S0034-988720090002000152009-06-10Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepáticaLugo-Baruqui,AlejandroBautista López,Carlos AlfredoArmendáriz-Borunda,Juan Cirrhosis Fibrosis Hepacivirus Hepatitis C Chroni Hepatitis C virus (HCV) infection represents a global health problem due to its evolution to hepatic cirrhosis and hepatocellular carcinoma. The viral pathogenesis and infectious processes are not yet fully understood. The development of natural viral resistance towards the host immune system represents a mayor challenge for the design of alternative therapeutic interventions and development of viral vaccines. The molecular mechanisms of hepatic fibrosis are well described. New alternatives for the treatment of patients with HCV infection and hepatic cirrhosis are under intensive research. New drugs such as viral protease inhibitors and assembly inhibitors, as well as immune modulators have been studied in clinical trials. Additional alternatives include antifibrotic drugs, which reverse the hepatic cellular damage caused by HCV infection. This review makes reference to viral infective mechanisms, molecular pathways of liver fibrosis and overviews conventional and new treatments for HCV infection and liver fibrosis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.2 20092009-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200015es10.4067/S0034-98872009000200015
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Cirrhosis
Fibrosis
Hepacivirus
Hepatitis C
Chroni
spellingShingle Cirrhosis
Fibrosis
Hepacivirus
Hepatitis C
Chroni
Lugo-Baruqui,Alejandro
Bautista López,Carlos Alfredo
Armendáriz-Borunda,Juan
Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática
description Hepatitis C virus (HCV) infection represents a global health problem due to its evolution to hepatic cirrhosis and hepatocellular carcinoma. The viral pathogenesis and infectious processes are not yet fully understood. The development of natural viral resistance towards the host immune system represents a mayor challenge for the design of alternative therapeutic interventions and development of viral vaccines. The molecular mechanisms of hepatic fibrosis are well described. New alternatives for the treatment of patients with HCV infection and hepatic cirrhosis are under intensive research. New drugs such as viral protease inhibitors and assembly inhibitors, as well as immune modulators have been studied in clinical trials. Additional alternatives include antifibrotic drugs, which reverse the hepatic cellular damage caused by HCV infection. This review makes reference to viral infective mechanisms, molecular pathways of liver fibrosis and overviews conventional and new treatments for HCV infection and liver fibrosis.
author Lugo-Baruqui,Alejandro
Bautista López,Carlos Alfredo
Armendáriz-Borunda,Juan
author_facet Lugo-Baruqui,Alejandro
Bautista López,Carlos Alfredo
Armendáriz-Borunda,Juan
author_sort Lugo-Baruqui,Alejandro
title Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática
title_short Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática
title_full Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática
title_fullStr Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática
title_full_unstemmed Nuevos tratamientos para la infección por virus de hepatitis C y el proceso de fibrosis hepática
title_sort nuevos tratamientos para la infección por virus de hepatitis c y el proceso de fibrosis hepática
publisher Sociedad Médica de Santiago
publishDate 2009
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200015
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AT bautistalopezcarlosalfredo nuevostratamientosparalainfeccionporvirusdehepatitiscyelprocesodefibrosishepatica
AT armendarizborundajuan nuevostratamientosparalainfeccionporvirusdehepatitiscyelprocesodefibrosishepatica
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