Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile

Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. M...

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Autores principales:	Brebi M,Priscilla, Ili G,Carmen Gloria, López M,Jaime, García M,Patricia, Melo A,Angélica, Montenegro H,Sonia, Leal R,Pamela, Guzmán G,Pablo, Roa S,Juan Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Genotype Human papilloma virus Uterine cervical neoplasms
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000300008
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spelling	oai:scielo:S0034-988720090003000082009-06-15Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, ChileBrebi M,PriscillaIli G,Carmen GloriaLópez M,JaimeGarcía M,PatriciaMelo A,AngélicaMontenegro H,SoniaLeal R,PamelaGuzmán G,PabloRoa S,Juan Carlos Genotype Human papilloma virus Uterine cervical neoplasms Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. Materials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. Results: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%), followed by HPV 18 (19.5%). Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66). No low-risk HPV genotypes were found. Conclusions: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.3 20092009-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000300008es10.4067/S0034-98872009000300008
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Genotype Human papilloma virus Uterine cervical neoplasms
spellingShingle	Genotype Human papilloma virus Uterine cervical neoplasms Brebi M,Priscilla Ili G,Carmen Gloria López M,Jaime García M,Patricia Melo A,Angélica Montenegro H,Sonia Leal R,Pamela Guzmán G,Pablo Roa S,Juan Carlos Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile
description	Background: The genotyping of Human Papillomavirus (HPV) will improve knowledge about the local epidemiological association of this virus with adenocarcinoma. Aim: To determine the frequency of HPV genotypes in biopsies of women with uterine cervical adenocarcinoma in a geographic region of Chile. Materials and Methods: Forty-one cervical biopsies with a pathological diagnosis of adenocarcinoma, corresponding to all women diagnosed with this cancer between 2002 and 2004, were analyzed. Viral gene Ll was amplified by PCRfor viral detection. HPV genotyping was carried out by a Reverse Line Blot technique. Results: Seventy one percent of biopsies were positive for HPV. The most common genotypes found were HPV 16 (61%), followed by HPV 18 (19.5%). Eighty seven percent of biopsies had a single HPV infection. Three patients had a multiple HPV infection. All of the latter were infected by HPV 16, associated with other three viral genotypes (45, 52 and 66). No low-risk HPV genotypes were found. Conclusions: In this sample of biopsies, there was a high prevelence of HPV 16 and a low prevalence of HPV 18, which historically has been related to adenocarcinoma. The genotypes found correspond to those described in South America.
author	Brebi M,Priscilla Ili G,Carmen Gloria López M,Jaime García M,Patricia Melo A,Angélica Montenegro H,Sonia Leal R,Pamela Guzmán G,Pablo Roa S,Juan Carlos
author_facet	Brebi M,Priscilla Ili G,Carmen Gloria López M,Jaime García M,Patricia Melo A,Angélica Montenegro H,Sonia Leal R,Pamela Guzmán G,Pablo Roa S,Juan Carlos
author_sort	Brebi M,Priscilla
title	Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile
title_short	Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile
title_full	Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile
title_fullStr	Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile
title_full_unstemmed	Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile
title_sort	detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, región de la araucanía, chile
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000300008
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Detección y tipificación de virus papiloma humano en adenocarcinoma de cuello uterino mediante reverse line blot, Región de La Araucanía, Chile

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