Marcadores de aterosclerosis temprana y síndrome metabólico en niños

Background: The high prevalence of obesity in children favors the appearance of metabolic syndrome (MS), increasing their cardiovascular risk. Aim: To evaluate components of MSin children and to comtate them with surrogate markers of atherosclerosis and subclinical inflammation. Material and methods...

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Autores principales:	Barja,Salesa, Acevedo,Mónica, Arnaiz,Pilar, Berríos,Ximena, Bambs,Claudia, Guzmán,Beatriz, Carvajal,Jacqueline, Cassis,Berta, Navarrete,Carlos
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Atherosclerosis Child Metabolic syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000400010
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spelling	oai:scielo:S0034-988720090004000102009-06-25Marcadores de aterosclerosis temprana y síndrome metabólico en niñosBarja,SalesaAcevedo,MónicaArnaiz,PilarBerríos,XimenaBambs,ClaudiaGuzmán,BeatrizCarvajal,JacquelineCassis,BertaNavarrete,Carlos Atherosclerosis Child Metabolic syndrome Background: The high prevalence of obesity in children favors the appearance of metabolic syndrome (MS), increasing their cardiovascular risk. Aim: To evaluate components of MSin children and to comtate them with surrogate markers of atherosclerosis and subclinical inflammation. Material and methods: We studied 209 children aged 11.5 ± 2 years (50% girls, 30% prepuberal). Fifty percent had normal weight, 18% were overweight, 29% were obese and 3% were undernourished. A fasting blood sample was obtained to measure lipid levels, glucose, insulin, adiponectin and ultrasensitive C-reactive protein (usCRP). Subclinical atherosclerosis was evaluated using flow mediated dilatation of brachial artery (FMD) and carotid intima-media thicknes (IMT). For diagnosis of MS we adapted Cook's criteria. Results: Five percent of all children and 18% ofthose with overweight had MS. Children with more components had significantly higher fasting insulin and Homeostasis Model Assessment (HOMA) values. Clustering of MS components was also associated to higher values of usCRP and non significantly to lower adiponectin levels. We did not find differences in FMD. In obese children there was a tendency towards a higher IMT with clustering of MS components, although not significant. Conclusions: Children with overweight presented a higher risk of a clusteríng of MS components, which was also associated with insulin resistance and increase in ultrasensitive C reactive protein.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.4 20092009-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000400010es10.4067/S0034-98872009000400010
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Atherosclerosis Child Metabolic syndrome
spellingShingle	Atherosclerosis Child Metabolic syndrome Barja,Salesa Acevedo,Mónica Arnaiz,Pilar Berríos,Ximena Bambs,Claudia Guzmán,Beatriz Carvajal,Jacqueline Cassis,Berta Navarrete,Carlos Marcadores de aterosclerosis temprana y síndrome metabólico en niños
description	Background: The high prevalence of obesity in children favors the appearance of metabolic syndrome (MS), increasing their cardiovascular risk. Aim: To evaluate components of MSin children and to comtate them with surrogate markers of atherosclerosis and subclinical inflammation. Material and methods: We studied 209 children aged 11.5 ± 2 years (50% girls, 30% prepuberal). Fifty percent had normal weight, 18% were overweight, 29% were obese and 3% were undernourished. A fasting blood sample was obtained to measure lipid levels, glucose, insulin, adiponectin and ultrasensitive C-reactive protein (usCRP). Subclinical atherosclerosis was evaluated using flow mediated dilatation of brachial artery (FMD) and carotid intima-media thicknes (IMT). For diagnosis of MS we adapted Cook's criteria. Results: Five percent of all children and 18% ofthose with overweight had MS. Children with more components had significantly higher fasting insulin and Homeostasis Model Assessment (HOMA) values. Clustering of MS components was also associated to higher values of usCRP and non significantly to lower adiponectin levels. We did not find differences in FMD. In obese children there was a tendency towards a higher IMT with clustering of MS components, although not significant. Conclusions: Children with overweight presented a higher risk of a clusteríng of MS components, which was also associated with insulin resistance and increase in ultrasensitive C reactive protein.
author	Barja,Salesa Acevedo,Mónica Arnaiz,Pilar Berríos,Ximena Bambs,Claudia Guzmán,Beatriz Carvajal,Jacqueline Cassis,Berta Navarrete,Carlos
author_facet	Barja,Salesa Acevedo,Mónica Arnaiz,Pilar Berríos,Ximena Bambs,Claudia Guzmán,Beatriz Carvajal,Jacqueline Cassis,Berta Navarrete,Carlos
author_sort	Barja,Salesa
title	Marcadores de aterosclerosis temprana y síndrome metabólico en niños
title_short	Marcadores de aterosclerosis temprana y síndrome metabólico en niños
title_full	Marcadores de aterosclerosis temprana y síndrome metabólico en niños
title_fullStr	Marcadores de aterosclerosis temprana y síndrome metabólico en niños
title_full_unstemmed	Marcadores de aterosclerosis temprana y síndrome metabólico en niños
title_sort	marcadores de aterosclerosis temprana y síndrome metabólico en niños
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000400010
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Marcadores de aterosclerosis temprana y síndrome metabólico en niños

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