La genética como factor pronóstico y terapéutico en el mieloma múltiple

The search for prognostic factors in multiple myeloma has identified the genetic profile of the tumor as the main determinant of patient survival and response to treatment. There is an association between a dismal prognosis and the presence of t(4:14) translocations or 17p deletion, determined by fl...

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Autores principales:	Conte L,Guillermo, Braggio,Esteban, Figueroa,Gastón, Fonseca,Rafael
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Citogenetics Genetic markers multiple myeloma
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000400015
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spelling	oai:scielo:S0034-988720090004000152009-06-25La genética como factor pronóstico y terapéutico en el mieloma múltipleConte L,GuillermoBraggio,EstebanFigueroa,GastónFonseca,Rafael Citogenetics Genetic markers multiple myeloma The search for prognostic factors in multiple myeloma has identified the genetic profile of the tumor as the main determinant of patient survival and response to treatment. There is an association between a dismal prognosis and the presence of t(4:14) translocations or 17p deletion, determined by fluorescent in situ hybridization (FISH) or the detection of chromosome 13 deletion using conventional cytogenetic techniques. These alterations define a subpopulation that comprises 25% of patients with a bad prognosis even if they are treated with high dose chemotherapy These patients should be early derived to more specific therapies. In the other hand, the other 75% of patients without a genetic risk factor, have a higher probability of success with conventional treatment.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.4 20092009-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000400015es10.4067/S0034-98872009000400015
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Citogenetics Genetic markers multiple myeloma
spellingShingle	Citogenetics Genetic markers multiple myeloma Conte L,Guillermo Braggio,Esteban Figueroa,Gastón Fonseca,Rafael La genética como factor pronóstico y terapéutico en el mieloma múltiple
description	The search for prognostic factors in multiple myeloma has identified the genetic profile of the tumor as the main determinant of patient survival and response to treatment. There is an association between a dismal prognosis and the presence of t(4:14) translocations or 17p deletion, determined by fluorescent in situ hybridization (FISH) or the detection of chromosome 13 deletion using conventional cytogenetic techniques. These alterations define a subpopulation that comprises 25% of patients with a bad prognosis even if they are treated with high dose chemotherapy These patients should be early derived to more specific therapies. In the other hand, the other 75% of patients without a genetic risk factor, have a higher probability of success with conventional treatment.
author	Conte L,Guillermo Braggio,Esteban Figueroa,Gastón Fonseca,Rafael
author_facet	Conte L,Guillermo Braggio,Esteban Figueroa,Gastón Fonseca,Rafael
author_sort	Conte L,Guillermo
title	La genética como factor pronóstico y terapéutico en el mieloma múltiple
title_short	La genética como factor pronóstico y terapéutico en el mieloma múltiple
title_full	La genética como factor pronóstico y terapéutico en el mieloma múltiple
title_fullStr	La genética como factor pronóstico y terapéutico en el mieloma múltiple
title_full_unstemmed	La genética como factor pronóstico y terapéutico en el mieloma múltiple
title_sort	la genética como factor pronóstico y terapéutico en el mieloma múltiple
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000400015
work_keys_str_mv	AT contelguillermo lageneticacomofactorpronosticoyterapeuticoenelmielomamultiple AT braggioesteban lageneticacomofactorpronosticoyterapeuticoenelmielomamultiple AT figueroagaston lageneticacomofactorpronosticoyterapeuticoenelmielomamultiple AT fonsecarafael lageneticacomofactorpronosticoyterapeuticoenelmielomamultiple
_version_	1718436439620845568

La genética como factor pronóstico y terapéutico en el mieloma múltiple

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