Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico

POEMS syndrome (polyneuropathy, organomegaly, endocrine abnormality, M-protein, plasma cell dyscrasia, and skin lesions) is a rare atypical plasma cell dyscrasia with characteristic para neoplastic manifestations. Glomeruloid hemangioma is a typical skin change pathogenetically related with elevated...

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Autores principales:	Chandía,Mauricio, Salomone,Claudia, Bertín,Pablo, González,Sergio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Paraproteinemias Plasma cells POEMS syndrome
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000500013
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spelling	oai:scielo:S0034-988720090005000132009-07-17Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínicoChandía,MauricioSalomone,ClaudiaBertín,PabloGonzález,Sergio Paraproteinemias Plasma cells POEMS syndrome POEMS syndrome (polyneuropathy, organomegaly, endocrine abnormality, M-protein, plasma cell dyscrasia, and skin lesions) is a rare atypical plasma cell dyscrasia with characteristic para neoplastic manifestations. Glomeruloid hemangioma is a typical skin change pathogenetically related with elevated levels of Vascular Endothelial Growth Factor (VEGF). We report a 69 year-old woman that presented cachexia associated with diabetes, hypothyroidism and severe sensitive motor polyneuropathy. Her skin changes included hyper pigmentation, acrocyanosis and glomeruloid hemangioma. The subsequent study revealed a monoclonal gammopathy lambda type; a unique lytic vertebral lesion and a clonal plasma cell proliferation. Treatment with prednisone 0.5 mg/kg and melphalan 0,25 mg/kg in cycles of 4 days every 4 weeks was started, but the patient was lost from follow up.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.5 20092009-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000500013es10.4067/S0034-98872009000500013
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Paraproteinemias Plasma cells POEMS syndrome
spellingShingle	Paraproteinemias Plasma cells POEMS syndrome Chandía,Mauricio Salomone,Claudia Bertín,Pablo González,Sergio Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico
description	POEMS syndrome (polyneuropathy, organomegaly, endocrine abnormality, M-protein, plasma cell dyscrasia, and skin lesions) is a rare atypical plasma cell dyscrasia with characteristic para neoplastic manifestations. Glomeruloid hemangioma is a typical skin change pathogenetically related with elevated levels of Vascular Endothelial Growth Factor (VEGF). We report a 69 year-old woman that presented cachexia associated with diabetes, hypothyroidism and severe sensitive motor polyneuropathy. Her skin changes included hyper pigmentation, acrocyanosis and glomeruloid hemangioma. The subsequent study revealed a monoclonal gammopathy lambda type; a unique lytic vertebral lesion and a clonal plasma cell proliferation. Treatment with prednisone 0.5 mg/kg and melphalan 0,25 mg/kg in cycles of 4 days every 4 weeks was started, but the patient was lost from follow up.
author	Chandía,Mauricio Salomone,Claudia Bertín,Pablo González,Sergio
author_facet	Chandía,Mauricio Salomone,Claudia Bertín,Pablo González,Sergio
author_sort	Chandía,Mauricio
title	Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico
title_short	Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico
title_full	Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico
title_fullStr	Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico
title_full_unstemmed	Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico
title_sort	síndrome de poems con lesión lítica aislada y hemangiomas glomeruloides: caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000500013
work_keys_str_mv	AT chandiamauricio sindromedepoemsconlesionliticaaisladayhemangiomasglomeruloidescasoclinico AT salomoneclaudia sindromedepoemsconlesionliticaaisladayhemangiomasglomeruloidescasoclinico AT bertinpablo sindromedepoemsconlesionliticaaisladayhemangiomasglomeruloidescasoclinico AT gonzalezsergio sindromedepoemsconlesionliticaaisladayhemangiomasglomeruloidescasoclinico
_version_	1718436443904278528

Síndrome de POEMS con lesión lítica aislada y hemangiomas glomeruloides: Caso clínico

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