Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional

Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic re...

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Autores principales:	Martínez R,Gonzalo, Alonso K,Rodrigo, Novik A,Victoria
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Insulin resistance Metabolic Syndrome X Obesity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000500014
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spelling	oai:scielo:S0034-988720090005000142009-07-17Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racionalMartínez R,GonzaloAlonso K,RodrigoNovik A,Victoria Insulin resistance Metabolic Syndrome X Obesity Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistence of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, which inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferators-activated receptors (PPAR) seems promising.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.5 20092009-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000500014es10.4067/S0034-98872009000500014
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Insulin resistance Metabolic Syndrome X Obesity
spellingShingle	Insulin resistance Metabolic Syndrome X Obesity Martínez R,Gonzalo Alonso K,Rodrigo Novik A,Victoria Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional
description	Regardless of the diagnostic criteria, the metabolic syndrome is found at least in 20% of the population. The adipose tissue plays an important role in the insulin resistance found in this syndrome. Free fatty acids released by intra-abdominal adipocytes produce an inflammatory and pro-thrombotic response and the persistence of the insulin resistance state, phenomenon termed lipotoxicity. This altered phenotype explains the development of the different components of the metabolic syndrome, such as hypertension, dyslipidemia and altered glucose metabolism. The treatment is based on weight loss and healthy lifestyle. A balanced diet, physical activity and avoidance of smoking are key management features. The use of drugs with pleiotropic effects, which inhibit the renin angiotensin aldosterone axis or acts on the peroxisome proliferators-activated receptors (PPAR) seems promising.
author	Martínez R,Gonzalo Alonso K,Rodrigo Novik A,Victoria
author_facet	Martínez R,Gonzalo Alonso K,Rodrigo Novik A,Victoria
author_sort	Martínez R,Gonzalo
title	Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional
title_short	Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional
title_full	Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional
title_fullStr	Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional
title_full_unstemmed	Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional
title_sort	síndrome metabólico: bases clínicas y fisiopatológicas para un enfoque terapéutico racional
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000500014
work_keys_str_mv	AT martinezrgonzalo sindromemetabolicobasesclinicasyfisiopatologicasparaunenfoqueterapeuticoracional AT alonsokrodrigo sindromemetabolicobasesclinicasyfisiopatologicasparaunenfoqueterapeuticoracional AT novikavictoria sindromemetabolicobasesclinicasyfisiopatologicasparaunenfoqueterapeuticoracional
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Síndrome metabólico: Bases clínicas y fisiopatológicas para un enfoque terapéutico racional

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